(Fused) benz(thio)amides and pharmaceutical use

ABSTRACT

A (fused) benz(thio)amide of the formula: ##STR1## wherein B represents 
     (i) a carbocyclic ring of from 4 to 8 members being unreplaced or replaced one, two or three of optional carbon atom(s) by oxygen, nitrogen and/or sulphur atom(s) or 
     (ii) a divalent group of the formula: ##STR2## R 1  represents a group of formula: ##STR3## (iv) a straight or branched alkyl, alkenyl, or alkynyl of from 1 to 20 carbon atoms, 
     R 4  represents 
     (i) when B represents a closed ring, a group of the formula: ##STR4## (ii) when B does not represent a ring, a group of formula: ##STR5##  with the proviso that compounds of formula: ##STR6##  wherein A&#39; is a vinylene or an ethylene group optionally substituted by straight or branched alkyl groups of from 1 to 4 carbon atom(s); 
     R 4&#39;   is 
     
         --(CH.sub.2).sub.n --COOR.sup.8 
    
      and 
     R 1&#39;  is 
     (i) a group of the formula: ##STR7##  or (ii) a group of the formula: ##STR8##  are excluded, wherein A, R 2 , R 3 , R 5 , R 6 , R 7 , R 8 , U, n, m, p, q, R 5&#39; , and R 6&#39;  are defined as in the above specification, possessing antagonistic activity on leukotrienes (SRS), inhibitory activity on 5α-reductase, on phospholipase and on aldose reductase and being useful for the prevention and/or treatment of diseases induced by leukotrienes, 5α-reductase, phospholipase and aldose reductase in mammals, especially in human beings.

DESCRIPTION Summary

This invention is related to novel (fused) benz(thio)amides.

More particularly, this invention is related to novel (fused) benz(thio)amides having an antagonistic activity on leukotrienes (SRS) and an inhibitory activity on 5α-Reductase; processes for the preparation of them; and pharmaceutical agent containing them as active ingredient.

BACKGROUND

In the study of prostaglandins (abbreviated as PG hereafter), many important discoveries have been made continuously in recent years. And so it was found a large change in the direction of the research and development of PG. In the compounds which have been newly found or newly confirmed their structure in PG family, it can be said that PG endoperoxides, (i.e. PGG₂ and PGH₂), thromboxane A₂ (abbreviated as TXA₂ hereafter), prostacyclin (i.e. PGI₂) and leukotriene C₄, D₄ and E₄ (abbreviated as LTC₄, LTD₄ and LTE₄, respectively, hereafter) etc. have especially strong and unique biological activities.

All the compounds of PG family containing various PG previously known well in addition to the above compounds, are biosynthesized from the same mother compound, i.e. arachidonic acid in a living body and, therefore, the metabolic routes starting from arachidonic acid is called "Arachidonate cascade" as a whole. The detailed explanation of each route and the pharmacological character of each metabolite are described in Igaku No Ayumi, 114, 378 (1980), ibid, 114, 462 (1980), ibid, 114, 866 (1980), ibid, 114, 929 (1980), Gendai Iryo, 12, 909 (1980), ibid, 12, 1029 (1980), ibid, 12, 1065 (1980) and ibid, 12, 1105 (1980) etc.

The arachidonate cascade can be largely divided into two routes; one is the route that cyclooxygenase acts on arachidonic acid to convert, into various PGs, e.g. prostaglandin F₂ (abbreviated PGF₂ hereafter), prostaglandin E₂ (abbreviated PGE₂ hereafter), PGI₂, TXA₂, via PGG₂ and further PGH₂ and the other is the route that lipoxygenase acts on arachidonic acid to convert, in hydroxyeicosatetraenoic acid (abbreviated as HETE hereafter) or leukotrienes, via hydroperoxyeicosatetraenoic acid (abbreviated HPETE hereafter).

As the former route is well known, it is not described in the present specification in detail. See Prostaglandin (1978), edited by Makoto Katori et al., published by Kohdan-sha.

Concerning the latter route, it has been known that various compounds are produced according to the following scheme I. ##STR9##

Besides being metabolized through a well known route, i.e. the route via PG endoperoxides, arachidonic acid is also metabolized through another route by the action of lipoxygenase. That is to say, arachidonic acid is metabolized by the action of lipoxygenase, e.g. 5-lipoxygenase, 12-lipoxygenase and 15-lipoxygenase, to 5-HPETE, 12-HPETE and 15-HPETE, respectively.

These HPETE are converted into 5-HETE, 12-HETE and 15-HETE, respectively, by the action of peroxides converting a hydroperoxy group into a hydroxy group. Furthermore, LTA₄ is also produced from 5-HPETE by dehydration. LTA₄ is converted into leukotriene B₄ (abbreviated as LTB₄ hereafter) or LTC₄ enzymatically. Further, LTC₄ is converted into LTD₄ by the action of γ-glutamyl transpeptidase.

Moreover, it was recently defined that LTD₄ is metabolized to LTE₄ (see Biochem. Biophys. Res. Commun., 91, 1266 (1979) and Prostaglandins, 19(5), 645 (1980)).

Besides, SRS is an abbreviation of Slow Reacting Substance and it was named by Feldberg et al. for the substance released when perfusing cobra venom through isolated lung or incubating cobra venom with vitellus. And it was reported that the substance constricted ilem isolated from guinea pig slowly and continually (see J. Physiol., 94, 187 (1938)).

Moreover, Kellaway et al. showed the relation between SRS-A and allergic reaction from the fact that SRS-A is released when an antigen is sensitized to perfusing lung isolated from guinea pig (see Quant. J. Exp. Physiol., 30, 121 (1940)).

Brocklehurst reported that when the antigen is sensitized to a lung fragment isolated from a bronchial asthmatics whose specific antigen is defined, by an operation, histamine and SRS-A are released and strongly constrict bronchial muscle. Since such constriction can not be prevented by an antihistaminic agent, he suggested that SRS-A is an important bronchoconstrictor in an asthmatic paroxysm (see Progr. Allergy, 6, 539 (1962)).

Since then, many reports were published, for instance, SRS-A prepared from human lung slice constrict a tracheal spiral of normal human (see Int. Arch. Allergy Appl. Immunol., 38, 217 (1970)); when SRS-A prepared from rats is injected intravenously to guinea pig, significant increase of pulmonary resistance is observed (see J. Clin. Invest., 53, 1679 (1974)); in addition, a subcutaneous injection of SRS-A to guinea pig, rat and monkey enhances vascular permeability (see Advances in Immunology, 10, 105 (1969), J. Allergy Clin. Immunol., 621, 371 (1978), Prostaglandins, 19(5), 779 (1980) etc.).

Generally, the substance released by immunological reaction is called SRS-A. On the other hand, the substance released by non-immunological reaction such as calcium ionophore is called SRS. However, the above two substances have many similarities to each other and, therefore, it is considered they would probably be the same substance.

Further, it was confirmed that SRS or SRS-A is a mixture of LTC₄ and LTD₄. So it can be understood that the pharmacological characters of these leukotrienes are the same as those of SRS or SRS-A (see Proc. Natl. Acad. Sci. USA, 76, 4275 (1979), Biochem. Biophys. Res. Commun., 91, 1266 (1979), Proc. Natl. Acad. Sci. USA, 77, 2014 (1980) and Nature, 285, 104 (1980)).

Based on the results of these studies, various leukotrienes (the structures of LTC₄, LTD₄ and LTE₄, and further other leukotrienes which may be confirmed in the future) biosynthesized from arachidonic acid via LTA₄, are considered to be important factors relating to the appearance of allergic tracheal and bronchial diseases, allergic lung diseases, allergic shock and various allergic inflammations.

To surpress leukotrienes is useful for the prevention and/or treatment of tracheal bronchial or lung diseases such as asthma, allergic lung diseases, allergic shock or various allergic diseases.

On the other hand, arachidonic acid is released from phospholipids by the action of phospholipase, and two routes were generally accepted that (1) one is the route that phospholipase A₂ is reacted on phosphatidyl choline, and (2) the other is the route that phospholipase C was reacted on phosphatidyl inositol to produce 1,2-diglyceride, and diglyceridelipase followed by monoglyceridelipase were reacted on it to release arachidonic acid (see Kagaku to Seibutsu (Chemistry and Biology), 21, 154 (1983)).

And it was known that arachidonic acid released is metabolized through two different routes i.e. (1) metabolizing route to bioactive substances e.g. prostaglandins (PGs), thromboxane A₂ (TXA₂) by cyclooxygenase, and (2) metabolizing route to bioactive substances e.g. SRS-A (Slow Reacting Substances of Anaphylaxis), hydroxyeicosatetraenoic acid (HETE) and leukotriene B₄ (LTB₄) by lipoxygenase (see Kagaku to Seibutsu (Chemistry and Biology), 21, 154 (1983)).

These metabolites are known as chemical mediators; for example, TXA₂ is a compound which have a potent activity of platelet aggregation and aotra contraction, SRS-A is a chemical mediator on asthma, LTB₄ is a chemical mediator on various inflammations (e.g. gout), and PGs are also chemical mediators on various inflammations which enhance a vascular permeability and a pain, and have a vasodilative action, pyrogenetic action and chemotactic action (see Prostaglandin (1978), edited by Makoto Katori et al, published by Kohdan-sha).

Arachidonic acid is converted and metabolized to various chemical mediators which act important physiological part in living body. And it was known that ill-balances of those chemical mediators induce various disorders.

And as antagonist of SRS, the groups of the compounds of general formula: ##STR10## (wherein from R¹ to R⁵ and R⁷ each represent a hydrogen atom, a hydroxy group, an alkyl group of from 1 to 6 carbon atom(s), an alkoxy group of from 1 to 6 carbon atom(s), an amino group, an acyl group, an acylamino group of from 2 to 6 carbon atoms, an alkenyl group of from 2 to 6 carbon atoms, a halogen atom or a phenylalkoxy group in which alkoxy have from 1 to 6 carbon atom(s); X represents a hydrocarbyl group of from 1 to 10 carbon atom(s) being optionally substituted by hydroxy group(s); A represents an oxygen atom or is absent; Q represents an alkylene, alkenylene or alkynylene group of from 2 to 6 carbon atoms which may be branched; D represents a carboxy group, a 5-tetrazolyl group or carbamido-5-tetrazolyl group.) were described in the patent publication by Fisons Co., Ltd. (see Japanese patent application No. 55-1273841 i.e. European patent publication No. 17332 or U.S. Pat. No. 4281008.).

And, the following compounds described in the patent publication by Kissei Pharmaceutical Co., Ltd, as anti-allergic agent, of the general formula: ##STR11## (wherein R¹ and R² each represent a hydrogen atom or an alkyl group with 1-4 carbon atoms; R³ and R⁴ each represent a hydrogen atom or may be combined together to form an additional chemical bond; X represents a hydroxyl group, a halogen atom, a straight or branched chain saturated or unsaturated alkyl group with 1-4 carbon atoms, a straight or branched chain saturated or unsaturated alkoxy group with 1-4 carbon atoms, an acyloxy group with 1-4 carbon atoms, or a cycloalkyl group with up to 6 carbon atoms; n is zero or an integer of 1-3 with the proviso that when n is 2 or 3; X's may be the same or different and that when two X's are commonly the alkyl or alkoxy group, both X's may be combined together to form a ring; and Y represents a straight or branched chain alkylene group or a straight or branched chain oxyalkylene group connected to the benzene nucleus through an oxygen atom.) as well as physiologically acceptable salts thereof. (see U.S. Pat. No. 4,026,896.)

And benzamides, i.e. compounds represented by the general formula (I) depicted hereafter, wherein the symbol B is opened and R⁴ is a group of the formula: --OCH₂ COOR, were described in the prior patent application by the present inventors. (see Japanese patent application Kokai Nos. 60-97946, 60-116657, 60142941 and 60-146855.)

DISCLOSURE OF THE INVENTION

The present inventors have synthesized novel compounds of the general formula (I) depicted hereafter, which have a structure characterized as a (thio)amido group substituted on a fused benzene ring or benzene ring and have found the compounds have potent antagonistic activity on leukotrienes (SRS), and then achieved the present invention.

And, the compounds of the present invention also inhibit phospholipase, so inhibit release of arachidonic acid from phospholipids, and therefore are useful for prevention and/or treatment of diseases induced by arachidonate metabolites e.g. TXA₂, PGs, leukotrienes in mammals including human beings, especially human beings.

Examples of the diseases to the subject are various allergic diseases induced by leukotrienes described above, thrombosis e.g. one induced by injury (damage) of cerebral or coronary, endothelium or intima and inflammations e.g. arthritis, rheumatism (see Junkan kagaku (Cardiovascular Science) 3, 484 (1983) Yakkyoku (Pharmacy) 34, 167 (1983)).

It was found that the compounds of the present invention also have an inhibitory activity on 5α-reductase described below, besides the activity of leukotriene antagonist and phospholipase inhibitor described above.

5α-Reductase presents in endoplasmic reticulum and nucleic acid, and it converts testosterone which is taken into a target tissue, into active 5α-dihydrotestosterone. The activated 5α-dihydrotestosterone induces cell proliferaction by binding to an intracellular receptor. Activation of this enzyme is considered to cause some diseases such as prostatic hypertrophy, resulting in pattern baldness and acne.

As a matter of course, the compounds of the present invention have no activity peculiar like hormones, and inhibit 5α-reductase, so suppress increasing of 5α-dihydrotestosterone, therefore suppress cell proliferation, and therefore are useful for the prevention and/or treatment of prostatic hypertrophy, male pattern baldness and acne in mammals including human beings especially human beings.

Furthermore, it was found that the compounds of the present invention also have an inhibitory activity on aldose reductases.

An aldose reductase is an enzyme which reduces an aldose (e.g. glucose, galactose) into the corresponding polyol (e.g. sorbitol, galactitol) in human beings or other animals. The sorbitol and galactitol produced by the action of this enzyme are accumulated in the crystalline lenses, the peripheral nerves, the kidney, etc. of diabetics including galactosemiacs thus causing the above described complications e.g. retinopathy, diabetic cataract, nerve disturbances or renal disorders (see Jap. J. Opthamol., 20, 399 (1976), Int. Congr. Ser. Excepta Med., 403, 594 (1977) and Metabolism, 28, 456 (1979)).

The compounds of the present invention have inhibitory activity on an aldose reductase and are therefore effective for the prevention and/or treatment of diabetic complications described above in mammals including human beings especially human beings.

That is the present invention relates to novel (fused) benz(thio)amides of the general formula: ##STR12## (wherein,

A represents a single bond or a group of methylene, ethylene, trimethylene, tetramethylene, vinylene, propenylene, butenylene, butadienylene or ethynylene group optionally being substituted by one, two or three of straight or branched alkyl group(s) of from 1 to 10 carbon atom(s) and/or phenyl group(s);

B represents

(i) a carbocyclic ring of from 4 to 8 members being unreplaced or replaced one, two or three of optional carbon atom(s) by oxygen, nitrogen and/or sulphur atom(s) (the ring may optionally be substituted by group(s) of oxo, thioxo and/or hydroxy group(s)) or

(ii) a divalent group of formula: ##STR13##

T represents an oxygen atom or a sulphur atom;

R¹ represents a group of general formula: ##STR14## (iv) a straight or branched alkyl, alkenyl or alkynyl group of up to 20 carbon atom(s);

(wherein R⁵ and R⁶ independently represent a hydrogen atom or a halogen atom or a straight or branched alkyl, alkenyl or alkynyl group of up to 20 carbon atom(s) unreplaced or replaced one, two, three, four or five of optional carbon atom(s) by oxygen atom(s), sulphur atom(s), halogen atom(s), nitrogen atom(s), benzene ring(s), thiophene ring(s), naphthalene ring(s), carbocyclic ring(s) of from 4 to 7 carbon atom(s), carbonyl group(s), carbonyloxy group(s), hydroxy group(s), carboxy group(s), azido group(s) and/or nitro group(s));

R² represents a hydrogen atom or a straight or branched alkyl group of from 1 to 6 carbon atom(s);

R³ represents a hydrogen atom, a halogen atom, a hydroxy group, a nitro group, a group of general formula: --COOR⁷ (wherein R⁷ represents a hydrogen atom or a straight or branched alkyl group of from 1 to 6 carbon atom(s).) or a straight or branched alkyl, alkoxy or alkylthio group of from 1 to 6 carbon atom(s);

R⁴ represents

(i) when B represents a closed ring, a group of general formula: ##STR15## (wherein U represents an oxygen atom or a sulphur atom; R⁸ represents a hydrogen atom or a straight or branched alkyl group of from 1 to 6 atom(s), n and m represent an integer of from 1 to 10, respectively, p and q represent zero or an integer of from 1 to 10, respectively) or

(ii) when B do not represent a ring, a group of general formula: ##STR16## (wherein R⁸, p and q represent the same meaning as depicted hereinbefore, with the proviso that, when the B represents a group of formula: ##STR17## p does not represent zero), with the proviso that, following compounds are excluded, i.e. compounds of general formula: ##STR18## (wherein the A' is a vinylene or ethylene group optionally being substituted by straight or branched alkyl group(s) of from 1 to 4 carbon atom(s), R^(4') is the general formula:

    --(CH.sub.2).sub.n --COOR.sup.8

wherein R⁸ and n are defined the same as hereinbefore)

and R^(1') is

(i) a group of the general formula: ##STR19## (wherein R^(5') and R^(6') are hydrogen atom(s), hydroxy group(s), halogen atom(s), straight or branched alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy or acyloxy group(s) of up to 4 carbon atom(s) or cycloalkyl group(s) of from 3 to 6 carbon atom(s), independently) or

(ii) a group of the general formula: ##STR20## (wherein R^(5') and R^(6') are the same meaning as depicted hereinbefore))

and non-toxic salts thereof, and processes for their preparation, and pharmaceutical agents including them or it as active ingredient.

The compounds of the present invention may be largely divided into the following two groups in accordance with whether B is a closed ring or not.

That is the present invention includes compounds of the general formula: ##STR21## (wherein A, B, R¹, R², R³, R⁴, T and U have the same meaning as described hereinbefore.)

Both of the compounds of the general formula (IA) and (IB) are novel compounds per se.

The compounds of the general formula (IA) are quite novel, in chemical structure, because they have a (thio)amido group as well as benzene ring(s) and/or chromone skelton as the essential group, compared with the compounds of Fisons of the general formula (A), described hereinbefore in the part of background.

The compounds of the general formula (IB) are also novel compounds and have been first found to have inhibitory activities on 5α-reductase, on lipoxygenase and on aldose reductase, besides antagonistic activity on leukotrienes.

In the general formula (I), examples of the groups represented by R⁵ and R⁶ are the following:

a hydrogen atom, a halogen atom

an alkyl group of from 1 to 20 carbon atom(s)

an alkenyl or alkynyl group of from 2 to 20 carbon atoms

an alkoxy or alkylthio group of from 1 to 19 carbon atom(s)

an alkenyloxy, alkenylthio, alkynyloxy or alkynylthio group of from 3 to 19 carbon atoms

an alkyl group of from 1 to 19 carbon atom(s) substituted by halogen atom(s) and/or hydroxy group(s)

an alkenyl or alkynyl group of from 2 to 19 carbon atoms substituted by halogen atom(s) and/or hydroxy group(s)

an alkoxy or alkylthio group of from 1 to 18 carbon atom(s) substituted by halogen atom(s) and/or hydroxy group(s)

an alkenyloxy, alkenylthio, alkynylthio or alkynyloxy group of from 3 to 18 carbon atoms substituted by halogen atom(s) and/or hydroxy group(s)

an alkyloxyalkyl, alkenyloxyalkyl or alkyloxyalkenyl group of up to 19 carbon atoms

a cycloalkyl, cycloalkyloxy or cycloalkylthio group of from 4 to 7 carbon atoms

a phenyl, phenoxy or phenylthio group

an alkyl group of from 1 to 19 carbon atom(s) which has carbocyclic ring(s) of from 4 to 7 carbon atoms, benzene ring(s), naphthalene ring(s) or thiophene ring(s) in the middle or at the terminal thereof

an alkoxy, alkylthio, alkenyloxy, alkenylthio, alkynyloxy or alkynylthio group of up to 18 carbon atom(s) which have carbocyclic ring(s) of from 4 to 7 carbon atoms, benzene ring(s), naphthalene ring(s) or thiophene ring(s) in the middle or at the terminal thereof

a phenylthioalkoxy or phenyloxyalkyloxy group wherein the alkyl moiety is a group from 1 to 17 carbon atom(s)

a carboxyalkyloxy or alkoxycarbonylalkyloxy group of up to 19 carbon atoms

an alkoxycarbonyloxyalkyloxy group of from 3 to 19 carbon atoms

an alkenylcarbonyloxy group of from 3 to 20 carbon atoms

an alkylcarbonyl group of from 2 to 20 carbon atoms

an azidoalkyl, nitroalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl group of up to 19 carbon atom(s)

an azidoalkyloxy, nitroalkyloxy, aminoalkyloxy, alkylaminoalkyloxy, dialkylaminoalkyloxy group of up to 18 carbon atom(s)

an alkenylcarbonylamino group of from 3 to 19 carbon atoms

an alkylamino group of from 1 to 19 carbon atom(s)

groups described above further substituted by halogen atom(s), hydroxy group(s), azido group(s), nitro group(s) and/or carboxy group(s)

Among the groups described above, preferable groups as R⁵ and R⁶ are the following groups:

a hydrogen atom

a halogen atom

a straight or branched alkyl group of from 1 to 20 carbon atom(s)

a straight or branched alkoxy group of from 1 to 19 carbon atom(s)

a straight or branched alkenyloxy group of from 3 to 19 carbon atoms

a straight or branched alkynyloxy group of from 3 to 19 carbon atoms

a straight or branched alkylthio group of from 1 to 19 carbon atom(s)

a straight or branched alkyl group of from 1 to 18 carbon atom(s) being substituted by halogen atom(s)

a straight or branched alkyloxyalkyl group of from 2 to 19 carbon atom(s)

a cycloalkyl, cycloalkylalkyl (wherein alkyl moiety is a group of from 1 to 8 carbon atom(s)) or cycloalkylalkyloxy (wherein alkyl moiety is a group of from 1 to 8 carbon atom(s)) group optionally substituted by straight or branched alkyl group(s) of from 1 to 8 carbon atom(s), hydroxy group(s), halogen atom(s) and/or nitro group(s)

a phenyl, phenylalkyl (wherein alkyl moiety is a group of from 1 to 8 carbon atom(s)), phenylalkyloxy (wherein alkyl moiety is a group of from 1 to 8 carbon atom(s)) or phenylalkenyloxy (wherein alkenyl moiety is a group of from 2 to 8 carbon atom(s)) group optionally substituted by straight or branched alkyl group(s) of from 1 to 8 carbon atom(s), hydroxy group(s), halogen atom(s) and/or nitro group(s)

a naphthyl, naphthylalkyl (wherein alkyl moiety is a group from 1 to 8 carbon atom(s)), naphthylalkoxy (wherein alkyl moiety is a group from 1 to 8 carbon atom(s)) or naphthylalkenyloxy (wherein alkenyl moiety is a group from 2 to 8 carbon atoms), group optionally substituted by straight or branched alkyl group(s), hydroxy group, halogen atom(s) and/or nitro group(s)

a straight or branched alkoxy, alkenyloxy or alkyloxyalkyloxy group of up to 18 carbon atom(s) substituted by carbonyl, carbonyloxy and/or hydroxy group(s)

a straight or branched alkoxy group of from 1 to 17 carbon atom(s) substituted by phenoxy or phenylthio group(s)

a straight or branched alkoxy group of from 1 to 18 carbon atom(s) substituted by thiophene ring(s)

a straight or branched alkyl, alkenyl, alkoxy or alkenyloxy group of up to 18 carbon atom(s) substituted by azido or nitro group(s) or amino group(s) optionally substituted by an alkyl group of from 1 to 6 carbon atom(s) (including dialkylamino group(s))

a straight or branched alkyl, alkenyl, alkoxy or alkenyloxy group of up to 18 carbon atom(s) replaced by two kinds groups which are carbonyl group(s) and amino group(s)

An alkyl group of from 1 to 20 carbon atom(s) in the present invention means a group of methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicocyl group and an isomeric group thereof.

And an alkenyl and alkynyl group of from 2 to 20 carbon atom(s) mean corresponding groups described above.

An alkyl group of from 1 to 6 carbon atom(s) in the present invention means a methyl, ethyl, propyl, butyl, pentyl, or hexyl group or an isomeric group thereof.

A cycloalkyl group of from 4 to 7 carbon atoms in the present invention means a cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl group.

A halogen atom in the present invention means a chlorine, bromine, iodine or fluorine atom.

In the present invention, when a certain carbon atom is replaced by another atom, a ring or a group, any carbon atom(s) can be replaced, so far as the replacement per se can be acceptable in chemically or physically. For example, "an isobutyl group replaced by a benzene ring in the middle or at the terminal" means a isopropylphenyl, dimethylphenylmethyl or 2-phenylpropyl group. When a carbon atom is replaced, hydrogen atom(s) may be added or removed suitably. For example, "a pentyl group replaced by a nitrogen atom at the 2nd position" means N-propylaminomethyl group.

And, for example, 2-(phenoxy)ethoxy group and 5-(2-chloro-4-nitrophenylthio)-5-methylpent-2-enyloxy groups are replaced one, two, three, four or five of optional carbon atom(s) from pentyl group and 6,8-dimethylnon-3-enyl group, respectively, and therefore they are included in the present invention.

These examples are merely illustrative and should not be construed as limiting upon the scope of the present invention. ##STR22##

And examples of carbocyclic rings of from 4 to 8 members being unreplaced or replaced one, two or three of optional carbon atom by oxygen, nitrogen and/or sulphur atom(s) (the ring may optionally be substituted by group(s) of oxo, thioxo and/or hydroxy group(s) represented by the B in the general formula (I) are following: ##STR23## (The rings above described may optionally be substituted by hydroxy group(s).)

The carbocyclic rings depicted above may be saturated rings or unsaturated ones, or aromatic rings or non-aromatic ones.

Any rings depicted above are preferable. And, when the rings are fused with benzene rings, the following fused benzene rings are especially preferable, i.e. the rings of the general formula ##STR24## are the following rings: ##STR25##

And compounds wherein the B is a opened group of the formula: ##STR26## are also preferable.

Process for the Preparation (1)

The present invention includes not only the compounds per se, non-toxic salts thereof, use or method, but also process for the preparation.

According to the present invention, the compounds of the present invention of the general formula (I) may be prepared by reacting a compound of general formula:

    R.sup.1 --A--COOH                                          (II)

(wherein R¹ and A have the same meaning as described hereinbefore.) or a corresponding dithioic acid and a compound of general formula: ##STR27## (wherein B, R², R³ and R⁴ have the same meaning as described hereinbefore.) to form amide-bond, and further subjecting the product thereof to saponification or and/or esterification, if desired.

Reactions to form amide-bond are well known, it may be carried out, for example;

(A) by the method with using mixed acid anhydride

(B) by the method with using acid halide

(C) by the method with using DCC (dicyclohexylcarbodimide)

Concrete description of the methods described above are as follows:

(A) method with using mixed acid anhydride may be carried out, for example; an acid of the general formula (II) is reacted with an acid halide (pivaloyl chloride, thionyl chloride, tosyl chloride, mesyl chloride, oxalyl chloride etc.) or an acid derivative (ethyl chloroformate, isobutyl chloroformate etc.) in an inert organic solvent (chloroform, methylene chloride, diethyl ether, THF etc.) or without solvents, in the presence of tertiary amine (pyridine, triethylamine, picoline etc.), at from 0° C. to 40° C. to give a mixed acid anhydride. The obtained acid mixed anhydride and an amine of the general formula (III) are reacted in an inert organic solvent (described above), at from 0° C. to 40° C.

(B) method with using acid halide may be carried out, for example; an acid of the general formula (II) is reacted with an acid halide (described above) in an inert organic solvent (described above) or without solvents at from -20° C. to a refluxing temperature of the solvent used to give an acid halide. The obtained acid halide and an amine of the general formula (III) are reacted in an inert organic solvent (described above) in the presence or absence of tertiary amine (described above) at from 0° C. to 40° C.

(C) method with using DCC may be carried out, for example; an acid of the general formula (II) and an amine of the general formula (III) are reacted in an inert organic solvent (described above) or without solvents in the presence or absence of tertiary amine (described above) using with DCC at from 0° C. to 40° C.

Preferably, the reactions (A), (B) and (C) described above are carried out in an atmosphere of inert gas (argon, nitrogen, etc.) under anhydrous conditions.

Process for the Preparation (2)

Among the compounds of the present invention, compounds of the general formula: ##STR28## (wherein R²⁰ represents methylene group or a single bond, and A, B, R¹, R², R³ and T have the same meaning as described hereinbefore.) may be prepared by reacting a compound of the general formula: ##STR29## (wherein A, B, R¹, R², R³ and T have the same meaning as described hereinbefore.) with an azide.

Reactions to induce a 2-tetrazolyl group from a cyano group with an azide are known, it may be carried out, for example; under anhydrous conditions, using with azide (sodium azide, lithium azide, potassium azide etc.), in the presence of weak acid (pyridium chloride, ammonium chloride, dimethylaniline hydrochloride etc.) in an inert organic solvent (dimethylformamide, N-methylpyrrolidone etc.) with heating.

Process for the Preparation (3)

Among the compounds of the present invention, compounds of the general formula: ##STR30## (wherein R⁵⁵ represents a hydrogen atom or a straight or branched alkyl group of from 1 to 6 carbon atom(s), and the A, R¹, R³, R²⁰ and T have the same meaning as described hereinbefore.) may be prepared by reacting a compound of general formula: ##STR31## (wherein to R¹, R³, A and T have the same meaning as described hereinbefore.) and a compound of general formula: ##STR32## (wherein X¹⁰ and X²⁰ represent halogen atoms respectively, and R⁵⁰ represents a straight or branched alkyl group of from 1 to 6 carbon atom(s), and R²⁰ has the same meaning as described hereinbefore.) and further, subjecting the product thereof to esterification and/or saponification, if desired.

Reactions to form a benzodioxane ring from catechol are known, and it may be carried out, for example, under on anhydrous conditions, in the presence of condensing agent (potassium carbonate, sodium carbonate etc.) in an inert organic solvent (acetone, methyl ethyl ketone, dioxane etc.), with heating.

Process for the preparation (4)

Among the compounds of the present invention, compounds of the general formula: ##STR33## (wherein R¹²¹ represents a group of general formula: --(CH₂)_(r) -- (wherein r represents zero or an integer of from 1 to 9.); R¹⁴⁰ represents a group of general formula: --COOR⁸ (wherein R⁸ has the same meaning as described hereinbefore) or a group of formula: ##STR34## And A, R¹, R², R³, T and U have the same meaning as described hereinbefore.) may be prepared by reacting a compound of general formula: ##STR35## (wherein A, R¹, R², R³, T and U have the same meaning as described hereinbefore.) and a compound of general formula:

    X.sup.110 --CH.sub.2 --R.sup.121 --R.sup.140               (XXXXVI)

(wherein X¹¹⁰ represents a halogen atom, and R¹²¹ and R¹⁴⁰ have the same meaning as described hereinbefore.) and further subjecting the product thereof saponification and/or esterification, if desired.

Reactions of O-alkylation are known, and it may be carried out, for example, under anhydrous conditions, in the presence of a base (sodium hydride, potassium carbonate, sodium carbonate etc.), in a polar aprotic solvent (diethyl ether, tetrahydropyran, acetone etc.) at from 0° C. to 100° C.

Process for the Preparation (5)

Among the compounds of the present invention of the general formula (I), certain compounds may be prepared from the corresponding compounds of the present invention.

For example, it may be carried out in the following reaction formula and reaction scheme [A]. ##STR36## (in the above case, a reaction starting with a compound of formula (Ic) which substitutes a butadienylene and butenylene groups, or group being substituted by an alkyl or phenyl group may also be carried out similarly.) ##STR37## (wherein the symbol represents whole group of the substituent R¹ and symbols therein are included in R¹ respectively. R¹ and groups in R¹ have the same meaning as described above in the following schemes. R³⁰ represents an alkyl, alkenyl or alkynyl group of up to 18 carbon atom(s).) ##STR38##

Each symbol in the scheme [A] represents the following meanings or as defined hereinbefore respectively.

R⁴⁰, R⁴¹ --an alkyl, alkenyl or alkynyl group of up to 18 carbon atom(s)

R⁴⁵ --a hydrogen atom or an alkyl, alkenyl or alkynyl group of up to 18 carbon atom(s)

T¹⁰ --an oxygen atom or a sulphur atom, or an imido group

M¹⁰ --a lithium, potassium or sodium atom

X¹ --a halogen atom

Processes for the Preparation of Intermediates

Intermediates described hereinbefore of the general formula (III), (IV), (V) and (XXXXV) may be prepared by the processes described in the following reaction schemes, respectively.

Each symbol in the schemes represent the following meanings or as described hereinbefore, respectively.

R²¹ --a straight or branched alkyl group of from 1 to 6 carbon atom(s)

R⁵¹, R⁵², R⁵³, R⁵⁶ --a straight or branched alkyl group of from 1 to 6 carbon atom(s)

R⁵⁴ --a hydrogen atom or a straight or branched alkyl group of from 1 to 6 carbon atom(s)

R⁷⁰, R⁷¹ --a trifluoroacetyl group

X³⁰, X⁴⁰, X⁵⁰ --a halogen atom

R¹²², R¹⁸⁰ --a straight or branched alkyl group of from 1 to 6 carbon atom(s)

R¹²⁵ --a group of formula: --U--(CH₂)_(n) -- or --(CH₂)_(p) -- (wherein U, n and p have the same meaning as described hereinbefore.)

R¹⁵⁰ --a trifluoroacetyl group

X¹²⁰, X¹³⁰, X¹⁴⁰, X¹⁵⁰ --a halogen atom

When B contains an imino group, it is preferable to protect by trifluoro group(s) etc., and to remove the protecting group(s) in a suitable step.

And compounds of the general formula (IIIj) may be prepared by the same procedure as the method to obtain compounds of general formula (IIIh) from compounds of general formula (IIIg). ##STR39##

Intermediates having 1,4-dithianaphthalene skeleton also may be prepared using with a compound of general formula: ##STR40## (Wherein R³ has the same meaning as described hereinbefore), which may be obtained by hydrolyzing a compound of general formula: ##STR41## (wherein R³ has the same meaning as described hereinbefore), instead of the compound of the general formula (XIII).

In the processes for the preparation of the compounds of the present invention, esterification and saponification may be carried out as follows.

Conversion of a certain acid into a corresponding ester (i.e. esterification) is a known reaction per se, and it may be carried out, for example;

(1) by the method using a diazoalkane

(2) by the method using an alkyl halide

(3) by the method using DMF-alkylacetal and

(4) by the method reacting with a corresponding alkanol

Concrete descriptions of the reactions above mentioned are as follows:

(1) the method using a diazoalkane may be carried out, for example, in an inert organic solvent (diethyl ether, ethyl acetate, methylene chloride, acetone, methanol, ethanol etc.) using with corresponding diazoalkane.

(2) the method using an alkyl halide may be carried out, for example, in an organic solvent (acetone, N,N-dimethylformamide, DMSO etc.), in the presence of a base (potassium carbonate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, calcium oxide etc.) using with a corresponding alkyl halide.

(3) the method using DMF-dialkylacetal may be carried out, for example, in an inert organic solvent (benzene, toluene etc.) using with a corresponding DMF-dialkylacetal.

(4) the method reacting with a corresponding alkanol may be carried out, for example, in a corresponding alkanol, using with an acid (hydrochloric acid, sulphuric acid, p-toluenesulphonic acid, hydrochloride gas etc.) or condensing agent (DCC, pivaloyl chloride, arylsulphonyl halide, alkylsulphonyl halide etc.).

Reactions mentioned above are carried out with a generally at from -10° C. to 100° C.; and they may be carried out further addition of inert organic solvent(s) (THF, methylene chloride etc.) not related to the reactions.

Conversion of a certain ester into corresponding acid (i.e. saponification) is a known reaction per se, and it may be carried out, for example;

(1) using with an aqueous solution of an alkali (potassium hydroxide, sodium hydroxide, lithium hydroxide, potassium carbonate, sodium carbonate etc.) in a water-miscible organic solvent (THF, dioxane, ethanol, methanol etc.).

(2) using an alkali mentioned above, in an alkanol (methanol, ethanol etc.) in anhydrous condition.

The reactions above are carried out generally at from -10° C. to 100° C.

In each reaction in the present invention, products may be purified by conventional manner. For example, it may be carried out by distillation at atmospheric or reduced pressure, high performance liquid chromatography, thin layer chromatography or column chromatography using silica gel or magnesium silicate, washing or recrystallization. Purification may be carried out after each reaction, or after a series of reactions.

Starting Materials

Starting materials and reagents in the present invention are known compounds per se or may be prepared by known methods per se.

For example, acids of the general formula (II) may be prepared by the methods described in the specification of Japanese Patent Application Kokai Nos. 60-97946, 60-116657, 60-142941, 60-142936 or 60146855.

A certain compound of the general formula (VIII) wherein R³ is a hydrogen atom is described in J. Med. Chem., 8, 446 (1965).

A certain compound of the general formula (XIII) wherein R³ is a hydrogen atom is described in J. Am. Chem. Soc., 75, 3277 (1953).

The compounds of the general formula (XV) may be prepared by the method described in J. Med. Chem., 20, 371 (1977).

A certain compound of the general formula (XXXI) wherein R³ is a hydrogen atom is described in J. Org. Chem., 42, 1925 (1977).

The compounds of the general formula (XXXXVIII) may be prepared from the compounds of the general formula (II).

Compounds of the general formula (XXXXVI), (XXXXVII) and (XXXXVIII) are known compounds per se, or may be prepared by known methods per se.

For example, compounds wherein B is a morpholine ring, compounds wherein B is 2,3,4,5tetrahydrofuran, compounds wherein B is a hydroxypyridine ring, compounds wherein B is 3,4,5,6-tetrahydro-2H-pyran ring may be prepared by the methods described in J. O. Chem., 32, 4155 (1967), Chem. Abst. 98, 179352 q (1983), J. O. Chem., 32, 4155 (1967), and Chem. Abst., 84, 58747z, respectively or similar methods thereof.

Salts

The compounds of the present invention of the general formula (I) may form salts at the carboxy or tetrazolyl moiety.

By converting into salts, solubility of the compounds of the present invention in water can be increased, and therefore may be more readily administered as pharmaceuticals.

The compounds of the present invention may easily be converted into corresponding salts by the methods known per se, e.g. methods described hereafter.

The salts in the present invention are preferably non-toxic ones. The non-toxic salts mean salts of cations that are relatively innocuous to living body (animals including human beings) tissues and that the effective pharmacological properties of the compounds of the general formula (I) are not impaired by side effect(s) resulting from the cations when used in an amount required for the prevention and/or treatment. And water-soluble salts are preferable.

Suitable salts include, for example, a salt of an alkali metal such as sodium, potassium, a salt of an alkaline metal such as calcium, magnesium, an ammonium salt and a pharmaceutically acceptable (non-toxic) amine salt.

Amines suitable for forming such salts with carboxylic acid or tetrazolyl group as well known and include, for example, those amines which are theoretically obtained by substituting one or more of hydrogen atom(s) of ammonia by other group(s). These groups, which may be the same or different when one or more hydrogen atom(s) are substituted, are selected from, for example, alkyl group(s) of from 1 to 6 carbon atom(s) and hydroxyalkyl group(s) of from 1 to 3 carbon atom(s). Suitable non-toxic amine salts include salts of a tetraalkylammonium group, such as tetramethylammonium salt and salts of an organic amine, such as methylamine, dimethylamine, cyclopentylamine, benzylamine, phenetylamine, piperidine, monoethanolamine, diethanolamine, lysine and alginine.

Salts can be obtained fro the compounds of the present invention of the general formula (I), by methods known per se, for example, by reacting the compound of the general formula (I) and a suitable base such as a hydroxide or carbonate of an alkali metal or alkaline earth metal, ammonium hydroxide, ammonia or an organic amine in theoretical amounts in an appropriate solvent.

The salts can be isolated by freeze-drying the solution, or by filtration if the salts are sufficiently insoluble to the reaction solution, or if necessary, by removing part of the solvent followed by filtration.

Pharmaceutical Activities

The compounds of the present invention possess an antagonistic activity on leukotrienes, inhibitory activity on phospholipase, on 50α-reductase and on aldose reductase.

In a standard laboratory test, for example, the compounds of the present invention showed the pharmaceutical activity in the following tables.

The compounds of the present invention showed an antagonistic activity on LTD₄ in vitro (method is described hereafter), shown in the following tables.

                  TABLE I                                                          ______________________________________                                         Antagonistic activity of compounds of following                                general formula on LTD.sub.4                                                    ##STR42##                    (IA')                                            R                    IC.sub.50 (μM)                                         ______________________________________                                         alkyl                0.07-40                                                   alkoxy               0.009-0.9                                                 alkenyloxy           0.0005-1.4                                                alkylnyloxy          0.0002-0.013                                              alkylthio            0.17-17.5                                                 alkoxy substituted by halogen atom                                                                  0.0004-0.007                                              cycloalkylalkoxy     0.08-0.2                                                  (alkyl)phenylalkoxy  0.0004-0.7                                                naphthylalkyl        0.008                                                     ______________________________________                                    

                  TABLE II                                                         ______________________________________                                         Antagonistic activity of compounds of following                                general formula on LTD.sub.4                                                    ##STR43##                   (IA")                                             R                     IC.sub.50 (μM)                                        ______________________________________                                         alkyl                 0.1-16                                                   alkoxy                0.004-2.3                                                alkenyloxy            0.02-1.8                                                 alkynyloxy            0.4-0.5                                                  alkylthio             0.3-1.1                                                  alkoxy substituted by halogen atom                                                                   0.003-0.08                                               cycloalkyl            0.5                                                      cycloakylalkoxy       0.09-1.5                                                 phenylalkoxy          0.009-0.7                                                ______________________________________                                    

                                      TABLE III                                    __________________________________________________________________________     Comparison of activity by alkylene chain change                                Formula                         IC.sub.50 (μM)                              __________________________________________________________________________      ##STR44##                      2.6                                             ##STR45##                      8.3                                             ##STR46##                      0.66                                            ##STR47##                      0.074                                           ##STR48##                      15.5                                            ##STR49##                      20.0                                           __________________________________________________________________________

As is obvious from the Tables I and II, compounds of 1,4-benzodioxane skelton having any substituent R, represented by the general formula (IA') or (IA") among the compounds of the present invention (i.e. the case when B and R⁴ are fixed and R¹ and A are changed in the general formula (I)) have enoung activity for pharmaceutical use.

And from the Table III, it is confirmed if alkylene moiety (corresponding to A in the general formula (I)) would be converted, compounds having the enough pharmaceutical activity are given.

In the following tables, the comparision of activity by the skeleton structure changes are shown.

                                      TABLE IV                                     __________________________________________________________________________     Comparison of activity by skeleton change (1)                                  Formula                       IC.sub.50 (μM)                                __________________________________________________________________________      ##STR50##                    0.37                                              ##STR51##                    0.03                                              ##STR52##                    0.69                                             __________________________________________________________________________

                  TABLE V                                                          ______________________________________                                         Comparison of activity by skeleton change (2)                                  Formula                    IC.sub.50 (μM)                                   ______________________________________                                          ##STR53##                 2.6                                                  ##STR54##                 0.18                                                 ##STR55##                 1.2                                                 ______________________________________                                    

                  TABLE VI                                                         ______________________________________                                         Comparison of activity by skeleton change (3)                                  Example       Symbol                                                           No.           B          IC.sub.50 (μM)                                     ______________________________________                                         1(501)                                                                                        ##STR56## 0.076                                                 1(505)                                                                                        ##STR57## 0.205                                                 1(514)                                                                                        ##STR58## 0.0046                                                1(516)                                                                                        ##STR59## 0.0026                                                1(518)                                                                                        ##STR60## 0.033                                                 1(521)                                                                                        ##STR61## 0.0013                                                ______________________________________                                    

And further, from the Tables IV, V and VI, it can be clear that compounds in which the basic structural skeleton contains various rings also possess enough activity compared with the compounds having 1,4-benzodioxane skeleton (i.e. the case that R¹ and A are fixed and the symbol B and R⁴ are changed).

According to the points above described, it is estimated fairly that replacement of an essential skeleton structure of a certain compound from 1,4-benzodioxane to various rings and/or change of the groups of general formula: R¹ --A-- in the general formula (I) also leads a compound having enough activity for pharmaceutical use.

From the arguments above described, it is fully expected that the full scope of the present invention has effective activity and therefore are useful as a for pharmaceutical agent.

Antagonistic activity of the compounds of the present invention on LTD₄ were measured by the following method.

A segment of ilem (2.5 cm) was removed from guinea pig 300-400 g and suspended in a Magnus tube containing Tyrodes solution. The tube was maintained at 37° C. and aerated with 95% O₂ --5% CO₂. After stabilizing from 30 mins, 5×10⁻⁹ g/ml of LTD₄ was added to the Magnus tube. Contraction length at the time and contraction lengths when the compounds of the present invention were challenged at some concentrations were measured, and the IC₅₀ value were calculated.

Inhibitory activity on 5α-reductase in vitro

The compounds of the present invention showed an inhibitory activity on 5α-reductase vitro (method is described hereafter), shown in the following table.

                  TABLE VII                                                        ______________________________________                                         Inhibitory activity on 5α-reductase                                             Example                                                                        No.    IC.sub.50 (μM)                                                ______________________________________                                                4(205) 2                                                                       4(206) 4                                                                       6(1)   5                                                                ______________________________________                                    

Inhibitory activity of the compounds of the present invention on 5α-reductase was measured by the following method.

Inhibitory activity of the compounds of the present invention on 5α-reductase (IC₅₀) in vitro was measured by the following method.

Compounds tested were incubated with radioactive [4-¹⁴ C]testosterone (5 μM) and NADPH (5×10⁻³ M) in the medium containing 5α-reductase, 0.09M Hepes (pH 7.4) and 0.22M sucrose at 37° C. for 60 mins. The reaction was stopped by adding solution of chloroform-methanol (1:2). The reaction mixture was centrifuged and the supernatant was separated by thin layer chromatographhy on silica gel using chloroform-methanol-acetic acid (99.2:0.6:0.2) as a developing solvent. Radioactivity of formed 5α-dihydrotestosterone was measured by TLC scanner. The values of IC₅₀ were determined by the inhibition percents of 5α-reductase activity measured by the above procedure (see Endocrinal, Japon., 18, 179 (1971).).

Toxicity

On the other hand, it was confirmed that the acute toxicity (LD₅₀) over the full scope of the present invention was more than 500 mg/kg animal body weight by intravenous administration. Therefore, the compounds of the present invention may be considered to be sufficiently safe and suitable for pharmaceutical use.

For example, the values of LD₅₀ of the compounds prepared in Examples 1(76), 1(212), 1(230) and 1(247) were more than 1000 mg/kg animal body weight by intravenous administration in male mice weighing 170-180 g, respectively.

Application for Pharmaceuticals

The present invention is also related to methods of use as a leukotriene antagonist, phospholipase inhibitor, 5α-reductase inhibitor and/or aldose reductase inhibitor.

To Supperssing leukotrienes is useful for the prevention and/or treatment of tracheal, bronchial or lung diseases such as asthma, allergic lung diseases, allergic shock or various allergic diseases in mammals including human beings, especially human beings.

To Inhibiting phospholipases (phospholipase A₂ and /or phospholipase C) is useful for the prevention and/or treatment of diseases induced by the metabolites of arachidonic acid including leukotrienes described above, e.g. thrombosis such as thrombosis induced by damage of cerebal or coronary, endothelium or intina and inflammations such as arthritis, rheumatism in mammals including human beings, especially human beings.

To Inhibiting 5α-reductase is useful for the prevention and/or treatment of prostatic hypertrophy, male pattern baldness or acne in mammals including human beings, especially human beings.

Inhibiting aldose reductase is useful for the prevention and/or treatment of diabetic complications e.g. retinopathy, diabetic cataract, nerve disturbances or renal disorders.

For the purposes hereinbefore described, the compounds of the present invention of the general formula or non-toxic salts thereof may normally be administered systemically or partially; usually by oral or parenteral administration.

The doses to be administered is determined depending upon age, body weight, symptom, the desired therapeutic effect, the route of administration, and the duration of the treatment etc. In the human adult, the doses per person per dose are generally between 0.1 mg and 100 mg, preferably between 2 mg and 20 mg, by oral administration, up to several times per day, and between 10 ug and 10 mg, preferably between 0.1 mg and 1 mg, by parenteral administratin up to several times per day.

As mentioned above, the doses to be used depend upon various conditions. Therefore, there are cases in which doses lower than or greater than the ranges specified above may be used.

Solid compositions according to the present invention for oral administration include compressed tablets, dispersible powders and granules. In such solid compositions, one or more of the active compound(s) is or are, admixed with at least one inert diluent such as lactose, mannitol, glucose, hydroxypropylcellulose, microcrystalline cellulose, starch, polyvinylpyrrolidone or magnesium metasilicate aluminate. The compositions may also comprise, as is normal practice, additional substances other than inert diluents e.g. lubricating agents such as magnesium stearate, disintegrating agents such as cellulose calcium gluconate, and assistant for dissolving e.g. arginine, glutamic acid or amine-acid such as aspartic acid. The tablets or pills may, if desired, be made into gastric film-coated or enteric film-coated tablets or pills, such as sugar-coated, gelatin-coated, hydroxypropyl cellulose-coated or hydroxypropylmethyl cellulose phthalate-coated tablets or pills; two or more of layers may be used. The compositions for oral administration also include capsules of absorbable material such as gelatin.

Liquid compositions for oral administration include pharmaceutically-acceptable emulsions, solutions, suspensions, syrups and elixirs containing inert diluents commonly used in the art such as distilled water or ethanol. Besides inert diluents such compositions may also comprise adjuvants such as wetting and suspending agents, and sweetening, flavoring, perfuming and preserving agents.

Other compositions for oral administration include spray compositions which may be prepared by known methods and which comprise one or more of the active compound(s).

Preparations for injection according to the present invention for parenteral administration include sterile aqueous or non-aqueous solutions, suspensions or emulsions. Examples of aqueous solvents or suspending media are distilled water for injection and physiological salt solution. Examples of non-aqueous solvents or suspending media are propylene glycol, polyethylene glycol, vegetable oils such as olive oil, alcohols such as ethanol, POLYSORBATE 80 (registered Trade Mark). These compositions may also include adjuvants such as preserving, wetting, emulsifying, despersing agents and assistant agent for dissolving (e.g. arginine, glutamic acid or amino-acid such as aspartic acid). They may be sterilized, for example, by filtration through a bacteria-retaining filter, by incorporation of sterilizing agents in the compositions or by irradiation. They may also be manufactured in the form by sterile solid compositions which can be dissolved in sterile water or some other sterile injectable medium immediately before use.

Other compositions for parenteral administration include liquids for external use, and endermic liniments such as ointments, suppositories and pessaries which comprise one or more of the active compound(s) and may be prepared by known methods.

Nomenclature and excluding compounds

Throughout the specification including claims, the compounds of the present invention are named as derivatives having the following fused benzene rings or benzene ring. ##STR62##

And throughout the specification including claims, isomers generated by the existence of stereo configuration unlimited (e.g. asymmetric carbon, double bond) are included in the corresponding formula, respectively.

With proviso that compounds which do not normally exist as judged from general chemical knowledge per se for chemical or physical reasons (e.g. certain compounds which neighboured with an oxygen, nitrogen or sulphur atom.) are excluded from the present invention.

REFERENCE EXAMPLES AND EXAMPLES

The following reference examples and examples illustrate the present invention, but should not be construed as limiting the present invention.

In the reference examples and examples, "TLC", "NMR", "IR" and "Mass" represent "Thin layer chromatography", "Nuclear magnetic resonance spectrum", "Infrared absorption spectrum" and "Mass spectrum", respectively.

The solvents in the parentheses show the developing or eluting solvents and the ratios of the solvents used are by volume in chromatographic separations.

Unless otherwise specified, "IR" was measured by the KBr tablet method and "NMR" was measured in a mixture of chloroform-d and ethanol-d₄ respectively.

REFERENCE EXAMPLE 1 Synthesis of 3-(m-methoxy-p-pentyloxycinnamoyl)aminopyrocatechol ##STR63##

Oxyalyl chloride (4.5 ml) was added to m-methoxy-p-pentyloxybenzoic acid (528 mg). In an atmosphere of argon, the solution was stirred for 30 min at room temperature and then concentrated under reduced pressure. The residue was dissolved into methylene chloride (10 ml). In an atmosphere of argon, the solution was dropped to a solution of 3 -aminopyrocatechol (275 mg) in a mixture of methylene chloride (10 mg) and pyridine (3 ml) cooling with ice, and the solution was stirred for 1 hr at the same temperture. After stirring for 2 hrs at room temperature, the solution was poured into 1N hydrochloric acid. The mixture was extracted with ethyl acetate. The extract was washed with water and a saturated aqueous solution of sodium chloride, successively, dried and concentrated under reduced pressure. Solids obtained was washed with hexane, and dried to give the title compound (700 mg) having the following physical data:

TLC: Rf 0.20 (ethyl acetate:hexane=1:2).

NMR (CDCl₃): δ 10.00(1H, s), 7.75(1H, d), 7.60(1H, s), 6.30-7.25(7H, m), 6.10(1H, s), 4.10(2H, t), 1.90(3H, s).

Mass: m/e 371(M⁺), 247, 177, 145, 125, 117, 89.

REFERENCE EXAMPLE 2 Synthesis of 8-(m-methoxy-p-pentyloxycinnamoyl)amino-1,4-dioxane-2-carbonitrile ##STR64##

Dry potassium carbonate (70 mg) and 2-chloroacrylonitrile (0.30 ml) were added to a solution of 3-(m-methoxy-p-pentyloxycinnamoyl)aminopyrocatechol (690 ml; synthesized in reference example 1) in acetone (10 ml). In a atmosphere of argon, the mixture was refluxed for 3 hrs. The reaction mixture cooled to room temperature was poured into ice-water (50 ml). The mixture was extracted with ethyl acetate. The extract was dried, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (methylene chloride:ethyl acetate=10:1) to give the title compound (565 mg) having the following physical data:

TLC: Rf 0.15 (ethyl acetate:hexane=1:2).

NMR (CDCl₃): δ 8.25(1H, dd), 7.70(1H, s), 7.00-7.25(2H, m), 6.90(1H, d), 6.85(1H, d), 6.70(1H, dd), 6.45(1H, d), 5.20(1H, dd), 4.30-4.55(2H, m), 4.05(2H, t), 3.93(3H, s).

Mass: m/e 422(M⁺), 247, 177, 145, 117.

REFERENCE EXAMPLE 3 (EXAMPLE A) Synthesis of 8-(p-pentylcinnamoyl)amino-1,4-benzodioxane-2-acetic acid methyl ester ##STR65##

Potassium carbonate (509 mg) was added to a solution of 3-(p-pentylcinnamoyl)aminopyrocatechol (300 mg; synthesized by the same procedure as reference example 1) and 4-bromo-2-butenoic acid methyl ester in acetone (10 ml), and the mixture was refluxed for 10 min. The reaction mixture was poured into water. The mixture was extracted with ethyl acetate. The extract was purified by column chromatography on silica gel (hexane:ethyl acetate=5:1) to give the title compound (341 mg).

REFERENCE EXAMPLE 4 Synthesis of 8-(p-pentylcinnamoyl)amino-1,4-benzodioxane-2-acetamide ##STR66##

8-(p-pentylcinnamoyl)amino-1,4-benzodioxane-2-acetic acid methyl ester (341 mg; synthesized in reference example 3) was dissolved into ethanol which was saturated with ammonia (20 ml). The solution was allowed to stand for 3 days at 100° C. The reaction mixture was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=2:1) to give the title compound (191 mg).

REFERENCE EXAMPLE 5 Synthesis of 8-(p-pentylcinnamoyl)amino-1,4-benzodioxane-2-acetonitrile ##STR67##

Trifluoroacetic anhydride (0.1 m) was added to a solution of 8-(p-pentylcinnamoyl)amino-1,4-benzodioxane-2-acetamide (191 mg; synthesized in reference example 4) in THF (10 ml) cooling with ice. And pyridine (0.02 ml) was added to the mixture. After stirring for 10 min, the mixture was poured into water. The mixture was extracted with ethyl acetate. The extract was dried, concentrated under reduced pressure to give the title compound.

EXAMPLE 1 Synthesis of 8-[p-(3Z-hexenyloxy)benzoyl]amino-2-(5-tetrazolyl)-1,4-benzodioxane ##STR68##

A mixture of p-(3Z-hexenyloxy)benzoic acid (110 mg) and oxalyl chloride (1 ml) was stirred for 1 hr at room temperature. From the mixture, excess oxalyl chloride was removed under reduced pressure. The residue was dried in vacuo, and then dissolved into methylene chloride (2 ml). In an atmosphere of argon, the solution was dropped into a solution of 8-amino-2-(5-tetrazolyl)-1,4-benzodioxane hydrochloride (128 mg) in a mixture of methylene chloride (2 ml) and pyridine (0.7 ml). The solution was stirred for 5 hrs at room temperature. The solution was diluted with ethyl acetate. The diluted solution was poured into 1N hydrochloric acid (1 ml). The mixture was extracted with ethyl acetate. The extract was washed with water, dried, and concentrated under reduced pressure. The residue was recrystallized from benzene to give the title compound (112 mg) having the following physical data:

TLC: Rf 0.57 (chloroform:methanol=3:1).

NMR: δ 7.90(2H, d), 7.88(1H, m), 7.46(1H, dd), 6.96(2H, d), 6.92(1H, t), 6.78(1H, dd), 5.77(1H, dd), 5.70(2H, m), 4.61(2H, m), 4.04(2H, t), 2.57(2H, dt), 2.12(2H, m), 1.01(3H, t).

IR: ν 3600-2300, 1650, 1610, 1540, 1505, 1460, 1250, 1175, 1090, 840, 770 cm⁻¹.

Mass: m/e 421(M⁺), 203.

Appearance: white powder.

EXAMPLE 1(1)-1(121)

By the same procedure as example 1, using with a corresponding carboxylic acid and 8-amino-2-(5-tetrazolyl)-1,4-benzodioxane hydrochloride, following compounds having the following physical data, shown in table [VIII] were given. ##STR69##

    TABLE VIII         Rf value in TLC     Example  (developing No. Substituent R in the      general formula (Im) solvent) NMR (δppm) IR (νcm.sup.-1) Mass      Appearance               1(1)       0.51(methylenechloride:methanol = 3:1) 7.87(2H, d), 7.50(1H, dd),      6.92(1H, t),6.77(1H, dd), 5.80(1H, dd), 4.68-4.54(2H, m), 2.68(2H, t),      1.74-1.54(2H, m),1.50-1.20(4H, m), 0.99(3H, t) 3400-2400, 1640,1610,      1540, 1460 393(M.sup.+),243,175 whitepowder       1(2)             ##STR70##       0.52(methylenechloride:methanol = 4:1) 7.83(2H, d), 7.49(1H, dd),      7.33(2H, d),6.91(1H, t), 6.75(1H, dd), 5.76(1H, dd),4.60(2H, m),      2.98(2H, t), 1.70(2H, m),1.39(4H, m), 0.90(3H, t) 3600˜2300,      1635,1620, 1595, 1545,1460, 1340, 1280,1265, 1100, 780 425, 207 whitepowd      er       1(3)             ##STR71##       0.47(methylenechloride:methanol = 4:1) 7.68(1H, d), 7.46(2H, d),      7.26(2H, d),6.89(1H, t), 6.73(1H, dd), 6.72(1H, d),5.71(1H, dd),      4.68(1H, dd), 4.49(1H, dd),2.96(2H, t), 1.68(2H, m), 1.39(4H, m),0.90(3H,       t) 3600˜2300, 1660,1620, 1595, 1545,1460, 1265, 1200,1090, 970,      820 451(M.sup.+)233 paleyellowcrystal       1(4)             ##STR72##       0.51(methylenechloride:methanol = 17:3) 7.69(2H, m), 7.53(2H, d),      6.98(2H, d),6.90(1H, t), 6.73(1H, dd), 6.58(1H, d),5.71(1H, dd),      4.70(3H, m), 4.48(1H, dd),2.24(2H, m), 1.14(3H, t) 3600-2200, 1640,1605,      1530, 1510,1450, 1260, 1170,995, 820 431(M.sup.+)219, 213 yellowpowder      1(5)       ##STR73##       0.40 (methylenechloride:methanol = 17:3) 7.69(2H, m), 7.50(2H, d),      6.90(1H, t),6.89(2H, d), 6.72(1H, dd), 6.62(1H, d),5.72(1H, dd),      4.67(1H, dd), 4.49(1H, dd),3.98(2H, t), 1.79(2H, m), 1.36(6H, m),0.90(3H,       t) 3600-2100, 16401600, 1530, 1500,1440, 1255, 1190,1160, 1090,      960,815, 760, 700 449(M.sup.+)231, 219 whitepowder       1(6)             ##STR74##       0.26(chloroform:methanol = 3:1) (CDCl.sub.3)8.23(1H, s), 7.79(2H, d),      7.22(2H, d), 7.05(1H, d), 6.84(1H, t), 6.72(1H, d), 5.69(1H, m),4.74(1H,      dd), 4.46(1H, dd), 2.64(2H, t), 1.60(2H, m), 1.15-1.45(12H, m), 0.87(3H,      t) 2930, 2860, 2740,1635, 1610, 1540,1450, 1325, 1275,1090, 1040,      900,850, 770, 715, 595 449(M.sup.+)299, 231,145, 131,118, 91 whitepowder       1(7)             ##STR75##       0.26(chloroform:methanol = 3:1) (CDCl.sub.3) 8.12(1H, s), 7.81(2H, d),      7.25(2H, d), 7.02(1H, d), 6.85(1H, t), 6.75(1H, d), 5.72(1H, m),4.80(1H,      dd), 4.47(1H, dd), 2.66(2H, t), 1.60(2H, m), 1.15-1.45(14H, m), 0.87(3H,      t) 2930, 2860, 1640,1620, 1605, 1540,1470, 1335, 1285,1270, 1100,      1050,920, 780 463(M.sup.+)313, 245,131, 118,91, 69 whitepowder  1(8)       ##STR76##       0.26(chloroform:methanol = 4:1) (CDCl.sub.3)7.94(1H, s), 7.84(2H, d),      7.30(2H, d), 6.70-7.00(3H, m), 5.76(1H, m), 4.92(1H, dd), 4.50(1H, dd),      2.68(2H, t), 1.63(2H, m), 1.15-1.45(16H, m), 0.88(3H, t) 2930, 2850,      1640,1615, 1545, 1460,1330, 1280, 1265,1095, 775 477(M.sup.+)327,      259,131, 118,91 whitepowder       1(9)             ##STR77##       0.26(chloroform:methanol = 4:1) CDCl.sub.3)7.97(1H, s), 7.84(2H, d),      7.28(2H, d), 6.70-7.00(3H, m), 5.74(1H, m), 4.90(1H,dd), 4.49(1H, dd),      2.68(2H, t), 1.63(2H,m), 1.15-1.45(18H, m) 2930, 2850, 1640,1615, 1545,      1460,1335, 1280, 1265,1090, 775, 491(M.sup.+)341, 273,131, 118,91      whitepowder       1(10)             ##STR78##       0.46(chloroform:methanol = 3:1) 7.70(2H, m), 7.54(2H, d), 6.94(2H,      d),6.91(1H, t), 6.74(1H, dd), 6.68(1H, d),6.05(1H, m), 5.74(1H, dd),      5.38(2H, m),4.70(1H, dd), 4.59(2H, d), 4.51(1H, dd) 3600-2200, 1650,1605,       1540, 1510,1455, 1260, 1200,1170, 1100, 1020, 980,960, 820, 780, 715      405(M.sup.+)219, 187 yellowpowder       1(11)             ##STR79##       0.45(chloroform:methanol = 3:1) 7.71(2H, m), 7.56(2H, d), 6.94(3H,      m),6.77(1H, m), 6.72(1H, d), 5.79(1H, m),4.72(1H, dd), 4.03(2H, m),      1.82(2H, m),1.35(8H, m), 0.92(3H, m) 3600-2200, 1650,1595, 1440,      1260,1170, 1090, 960,820 463(M.sup. +)245, 231,219 yellowpowder  1(12)       ##STR80##       0.39(chloroform:methanol = 3:1) 7.89(2H, d), 7.46(1H, dd), 6.88(2H,      d),6.81(1H, t), 6.75(5H, dd), 5.77(1H, dd),4.62(2H, m), 4.04(2H, t),      1.80(2H, m),1.51(2H, m), 0.90(3H, t) 3600-2300, 1630,1600, 1540,      1500,1450, 1250, 1170,1085, 840, 770 395(M.sup.+)177 whitepowder  1(13)       ##STR81##       0.46(chloroform:methanol = 3:1) 7.89(2H, m), 7.46(1H, dd), 6.96(2H,      d),6.92(1H, t), 6.76(1H, dd), 5.76(1H, dd),4.62(2H, m), 4.02(2H, t),      1.81(2H, m),1.26(10H, m), 0.88(3H, t) 3600-2300, 1630,1605, 1540,      1505,1460, 1260, 1180,1090, 840, 770 465(M.sup.+)247 whitepowder  1(14)       ##STR82##       0.42(chloroform:methanol = 3:1) 7.72(1H, d), 7.64(1H, m), 7.48(2H,      d), 7.36(2H, s), 7.22(6H, m), 6.90(1H, t),6.73(1H, dd), 6.72(1H, d),      5.70(1H, dd),4.67(1H, dd), 4.49(1H, dd), 3.99(2H, s) 3600-2300, 1640,1600      , 1540, 1450,1255, 1200, 1090,970, 960, 730,690 439(M.sup.+)259, 221      whitepowder       1(15)             ##STR83##       0.44(chloroform:methanol = 3:1) 7.72(1H, d), 7.66(1H, m), 7.49(2H,      d),7.23(2H, d), 6.90(1H, t), 6.75(1H, d),6.74(1H, dd), 5.72(1H, dd),      4.68(1H, dd),4.49(1H, dd), 2.53(1H, m), 1.86(5H, m),1.40(5H, m) 3600-2300      , 1650,1600, 1540, 1480,1455, 1260, 1210,1090, 980, 960,820, 690      431(M.sup.+)219, 213 yellowpowder       1(16)             ##STR84##       0.30(chloroform:methanol = 5:1) 7.74(1H, d), 7.48(2H, d), 6.88(2H,      d),6.88(1H, t), 6.74(1H, dd), 7.44(1H, s),5.72(1H, t), 4.62(2H, d),      4.01(2H, t) 1660, 1610, 1580,1540, 1515, 1460, 435(M.sup.+)217  whitepowd      er       1(17)             ##STR85##       0.30(methylenechloride:methanol = 5:1) 7.40(2H, d), 7.36(1H, d),      7.18(2H, d),6.89(1H, t), 6.74(1H, dd), 6.27(1H, d),5.74(1H, t), 4.72-4.50      (2H, m) 3300, 3200-2300,1660, 1610, 1540,1460 433(M.sup.+)215 whitepowder        1(18)             ##STR86##       0.48(chloroform:methanol = 3:1) 7.69(1H, d), 7.63(1H, m), 7.51(2H,      d),6.90(2H, d), 5.90(1H, m), 5.72(1H, dd),5.16(2H, m), 4.68(1H, dd),      4.49(1H, dd),4.04(2H, t), 2.56(2H, dt) 360-2300, 1650,1600, 1540,      1505,1450, 1255, 1200,1170, 1095, 1020,960, 820 419(M.sup.+)219, 201     y      paleellowpowder       1(21)             ##STR87##       0.26(chloroform:methanol = 3:1) (CDCl.sub.3)7.94(1H, s), 7.87(2H, d),      6.70-7.10(5H,m), 5.75(1H, m), 4.88(1H, dd), 4.50(1H, dd), 4.01(2H, t),      1.82(2H, m), 1.20-1.60(6H, m), 0.92(3H, t) 3420, 2930, 2860,1635, 1605,      1540,1505, 1460, 1255,1175, 1090, 840,775 423(M.sup.+)395, 273,205,      177,121 whitepowder       1(22)             ##STR88##       0.26(chloroform:methanol =       3:1) (CDCl.sub.3)7.80-8.00(2H, m), 6.70-7.05(5H, m), 5.74(1H, m),      4.90(1H, dd), 4.49(1H, dd),4.00(2H, t), 1.80(2H, m), 1.15-1.70(8H,m),      0.89(3H, t) 3420, 2930, 2860,1640, 1605, 1550,1510, 1460, 1260,1180,      1100, 845,775 437(M.sup.+)287, 219,121, 93 whitepowder       1(23)             ##STR89##       0.26(chloroform:methanol =       3:1) CDCl.sub.3)7.75-8.00(3H, m), 6.70-7.05(5H, m),5.74(1H, m),      4.90(1H, dd), 4.48(1H, dd),4.00(2H, t), 1.80(2H, m), 1.10-1.60(10H, m),      0.88(3H, t) 3430, 3320, 2930, 2850, 2730, 1635,1605, 1545, 1505,1460,      1320, 1255,1180, 1090, 840, 770 451(M.sup.+)396, 301,233, 121,93      whitepowder       1(24)             ##STR90##       0.26(chloroform:methanol =       3:1) (CDCl.sub.3)7.75-8.00(3H, m), 6.70-7.05(5H, m),5.76(1H, m),      4.94(1H, dd), 4.50(1H, dd),4.02(2H, t), 1.80(2H, m), 1.10-1.70(14H, m),      0.80(3H, t) 3420, 2930, 28501640, 1610, 1545,1510, 1460, 1260,1180,      1100, 845,775 479(M.sup.+)261, 121,93 whitepowder       1(25)             ##STR91##       0.26(chloroform:methanol = 3:1) (CDCl.sub.3)7.94(1H, s), 7.86(2H, d),      6.70-7.10(5H, m), 5.74(1H, m), 4.87(1H, dd),4.48(1H, dd), 4.04(2H, t),      1.60-1.95(3H, m), 0.98(6H, d) 3420, 2960, 2870,1635, 1605, 1540,1505,      1460, 1260,1180, 1100, 840,775 409(M.sup.+)191, 121,93 whitepowder      1(26)       ##STR92##       0.26(chloroform:methanol = 3:1) (CDCl.sub.3)7.88(2H, d), 7.83(1H, s),      6.75-7.10(5H,m), 5.76(1H, m), 4.96(1H, dd), 4.50(1H,dd), 4.01(2H, t),      1.20-1.95(5H, m),0.93(6H, d) 3420-2960, 2870,1640, 1610, 1545,1510,      1460, 1260,1180, 1100, 845,775 423(M.sup.+)381, 205,161, 121,93 whitepowd      er       1(27)             ##STR93##       0.53(chloroform:methanol = 3:1) 7.48(2H, m), 7.32(2H, d), 6.82(4H,      m),6.75(1H, t), 6.65(1H, dd), 6.14(1H, d),5.63(1H, dd), 4.59(1H, dd),      4.42(1H, dd),3.86(2H, t), 1.74(2H, m), 0.97(3H, t) 3600-2300, 1650,1600,      1440, 1250,1160, 1120, 1090,980, 830, 760 433(M.sup.+)215 yellowpowder      1(28)       ##STR94##       0.49(chloroform:methanol = 3:1) 7.58(2H, m), 7.39(2H, d), 7.27(2H,      d),6.92(3H, m), 6.74(1H, dd), 6.28(1H, d),5.72(1H, dd), 4.68(1H, dd),      4.51(1H, dd),2.62(2H, t), 1.60(2H, m), 1.36(2H, m),0.94(3H, t) 3600-2200,       1650,1600, 1530, 1440,1260, 1095, 990,835 431(M.sup.+)219,213 yellowpowd      er       1(29)             ##STR95##       0.30(methylenechloride:methanol = 5:1) 7.89(2H, d), 7.23(1H, dd),      6.96(2H, d),6.90(1H, t), 6.77(1H, dd), 6.02-5.80,(1H, m), 5.80-5.74(1H,      m), 5.26-5.08,(2H, m), 4.84-4.50(2H, m) 3500-2300, 1635,1605, 1540,      1      1505,455, 1250 393(M.sup.+)191, 175 whitepowder       1(30)             ##STR96##       0.65(chloroform:methanol = 3:1) 7.70(1H, d), 7.61(1H, m), 7.51(2H,      d),6.90(1H, t), 6.89(2H, d), 6.73(1H, dd),6.64(1H, d), 5.72(1H, dd),      5.50(2H, m),4.68(1H, dd), 4.50(1H, dd), 4.00(2H, t),2.55(2H, m),      2.10(2H, m), 1.00(3H, t) 3600-2100, 1650,1600, 1500, 1440,1250, 1160,      1090,1010, 960, 820 447(M.sup.+)229, 219 yellowpowder       1(31)             ##STR97##       0.40(methylenechloride:methanol = 4:1) 7.31(1H, d), 7.48(1H, d),      7.48(2H, d),6.89(1H, t), 6.87(2H, d), 6.74(1H, dd),6.56(1H, d), 5.80-5.68      (1H, m),4.70-4.30(3H, m), 1.30(3H, d) 3500-2300, 1660,1605, 1540,      1515,1460, 1260 435(M.sup.+)217 paleyellowpowder       1(32)             ##STR98##       0.61(chloroform:methanol = 3:1) 7.72(1H, d), 7.62(1H, m), 7.51(2H,      d),6.92(2H, d), 6.91(1H, t), 6.74(1H, dd),6.62(1H, d), 5.68(3H, m),      4.60(4H, m),2.18(4H, m), 2.18(2H, m), 1.04(3H, t) 3600-2200, 1645,1600,      1540, 1505,1450, 1260, 1165,1100, 820 501,433(M.sup.+)287, 219,215       p      yellowowder       1(33)             ##STR99##       0.42(chloroform:methanol = 3:1) 7.87(2H, d), 7.38(1H, dd), 6.93(2H,      d),6.90(1H, t), 5.75(1H, dd), 4.68(1H, dd),4.55(1H, dd), 4.46(1H, m),      1.72(2H, m),1.46(2H, m), 1.31(3H, d), 0.94(3H, t) 3600-2300, 1630,1600,      1540, 1500,1455, 1250, 1180,1100, 840, 770 409(M.sup.+)219, 191 whitepowd      er       1(34)             ##STR100##       0.44(chloroform:methanol = 3:1) 7.92(2H, d), 7.45(1H, dd), 7.05(2H,      d),6.92(1H, t), 6.77(1H, dd), 5.76(1H, dd),4.75(2H, t), 4.64(2H, m),      2.22(2H, m),1.50(2H, m), 1.32(4H, m), 0.88(3H, t) 3600-2200, 1635,1600,      1540, 1500,1450, 1260, 1220,1170, 1080, 990,835, 760 447(M.sup.+)229,      219 paleyellowpowder       1(35)             ##STR101##       0.46(chloroform:methanol = 3:1) 7.90(2H, d), 7.45(1H, dd), 6.98(2H,      d),6.92(1H, t), 6.76(1H, dd), 5.76(1H, dd),5.69(2H, m), 4.64(4H, m),      2.14(2H, m),1.40(2H, m), 1.32(4H, m), 0.89(3H, t) 3600-2300, 1630,1600,      1500, 1450,1240, 1165, 1080,830, 760 449(M.sup.+)329, 231,219 paleyellows      olid       1(36)             ##STR102##       0.10(chloroform:methanol = 4:1) CDCl.sub.3)7.80-8.00(3H, m), 7.32(2H,      d), 7.19(2H, d), 6.70-7.10(5H, m), 5.74(1H, m),5.08(2H, s), 4.89(1H, dd) 3      420, 2930, 2850,1630, 1605, 1540,1500, 1455, 1245,1170, 1090, 840,770      485(M.sup.+)399, 365,339, 267253, 219,147, 131 whitepowder  1(37)       ##STR103##       0.35(methylenechloride:methanol = 5:1) 7.90(2H, d), 7.34(1H, dd),      6.98(2H, d),6.92(1H, t), 6.78(1H, dd), 6.00-5.60(3H, m), 4.80-4.50(4H,      m) 3400, 3200- 23001630, 1595, 1540,1500, 1450, 1240 463(M.sup.+)343,      245,219, 121 palebrownpowder       1(38)             ##STR104##       0.30(methylenechloride:methanol = 5:1) 7.73(1H, d), 7.49(2H, d),      6.90(2H, d),6.90(1H, t), 6.75(1H, dd), 6.58(1H, d),6.00-5.60(3H, m),      4.70-4.40(4H, m) 3350, 3100-23001650, 1595, 1530,1500, 1450, 1260      489(M.sup.+)379, 343,271 whitepowder       1(39)             ##STR105##       0.40(benzene:dioxan:acetic acid = 20:10:1) 7.9(2H, d), 7.5-7.3(1H, m),      7.0-6.7(4H,m), 5.78(1H, m), 4.7-4.5(2H, m), 3.8(2H, m), 2.0-1.6(6H, m),      1.4-1.0(5H,m) 2920, 2850, 1620,1600 435(M.sup.+)217 whitepowder  1(40)       ##STR106##       0.4(benzene: dioxan:acetic acid = 20:10:1) 7.9(2H,d), 7.5-7.3(1H, m),      7.0-6.7(4H,m), 5.75(1H, m), 4.8-4.5(2H, m),4.0(2H, t), 3.55(2H, t),      1.8(4H, s),1.5(4H, s) 2950, 2850, 1630,1600, 1460, 1250 457(M.sup.+)239      whitepowder       1(41)             ##STR107##       0.4(benzene:dioxan:acetic acid = 20:10:1) 7.9(2H, d), 7.5-7.3(1H, m),      7.0-6.7(4H, m),5.75(1H, m), 4.8-4.5(2H, m), 4.05(2H, t),3.65(2H, t),      1.85(4H, 2), 1.7(2H, s) 2950, 2850, 1630,1600, 1460, 1250 443(M.sup.+)225       whitepowder       1(42)             ##STR108##       0.4(benzene:dioxan:acetic acid = 20:10:1) 7.9(2H, d), 7.5-7.3(1H, m),      7.0-6.7(4H, m),5.78(1H, m), 4.8-4.5(2H, m), 4.1(2H, s),3.65(2H, s),      2.6(4H, s) 1670, 1640, 1490,1290 -- whitepowder       1(43)             ##STR109##       0.10(chloroform:methanol = 4:1) 7.98(1H, d), 7.82(1H, dd), 7.28(1H,      m),7.00(1H, d), 6.90(1H, t), 6.78(1H, dd),5.60-6.00(3H, m), 4.45-4.85(4H,       m),2.10(2H, m), 1.20-1.50(6H, m),0.88(3H, t) 2930, 2860, 1640,1615,      1600, 1545,1500, 1460, 1270,1100, 1060, 980,780 483(M.sup.+)373,      329,265, 219,155, 149 whitepowder       1(44)             ##STR110##       0.4(benzene:dioxan:aectic acid = 20:10:1) 7.7(1H, d), 7.6-7.4(3H, m),      7.0-6.8(3H, m),6.75(1H, d), 6.6(1H, d), 5.7(1H, s),4.8-4.4(2H, m),      4.0(2H, t), 3.55(2H, t) 2900, 1640, 1600,1530, 1500, 1480,1450 265      palebrownpowder       1(45)             ##STR111##       0.4(benzene:dioxan:acetic acid = 20:10:1) 7.7(1H, d), 7.6-7.4(3H, m),      7.0-6.8(3H, m),6.75(1H, d), 5.7(1H, s), 4.8-4.4(2H, m),4.0(2H, t),      2.0-1.6(6H, m), 1.5-0.9(5H, m) 3300, 2920, 1650,1600, 1510, 1450,1250      461(M.sup.+)243 palebrownpowder       1(46)             ##STR112##       0.4(benzene:dioxan:acetic acid = 20:10:1) 7.75(1H, d), 7.6-7.4(3H, m),      7.0-6.8(3H,m), 6.75(1H, d), 6.6(1H, d), 5.75(1H, s),4.8-4.5(2H, m),      4.05(2H, s), 3.7(2H, s) 2950, 1650, 1600,1540, 1500, 1450,1250 237      palebrownpowder       1(47)             ##STR113##       0.4(benzene:dioxan:acetic acid = 20:10:1) 7.7(1H, d), 7.6-7.4(3H, m),      7.0-6.8(3H, m), 6.8-6.7(1H, m), 6.6(1H, d),6.7(1H, m), 4.8-4.4(2H, m),      4.0(2H, t),3.6(2H, t) 2950, 1650, 1600,1540, 1500, 1450,1250 252      whitepowder       1(48)             ##STR114##       0.30(methylenechloride:methanol =  5:1) 7.88(2H, d), 7.26(1H, dd),      6.97(2H, d),6.90(1H, t), 6.77(1H, dd), 6.00-5.60(3H, m), 4.80-4.50(4H,      m) 3300, 3300-2300,1640, 1610, 1550,1510, 1460, 1260 421(M.sup.+)301,      219,203 paleyellowpowder       1(49)             ##STR115##       0.38(methylenechloride:methanol = 5:1) 7.85(2H, d), 7.29(1H, dd),      6.92(2H, d),6.87(1H, t), 6.73(1H, dd), 5.80-5.68(1H, m), 5.65-5.33(2H,      m), 4.66(1H, dd),4.52(1H, dd) 3420, 3300,3300-2200, 1630,1600, 1540,      1500,1460, 1250, 840,770 435(M.sup.+)409, 217,191 whitepowder  1(50)       ##STR116##       0.25(chloroform:methanol = 4:1) 7.45-7.80(3H, m), 7.36(1H, dd),      6.80-7.00(2H, m), 6.72(1H, dd), 6.60(1H, d),5.70(1H, m), 4.66(1H, dd),      4.51(1H, dd),4.04(2H, t), 1.85(2H, m), 1.30-1.60(4H, m), 0.95(3H, t)      3350, 2940, 2860,1660, 1610, 1600,1530, 1495, 1455,1265, 1200, 1100,      1060,970, 915, 850, 810 469(M.sup.+)251, 219,181, 153,69 palebrownpowder       1(51)             ##STR117##       0.25(chloroform:methanol =       4:1) (CDCl.sub.3)7.80-8.05(3H, m), 7.15-7.45(4H, m), 6.70-7.15(5H, m),      5.76(1H, m), 5.13(2H, s),4.93(1H, dd), 4.50(1H, dd), 2.67(2H, t),      1.90(1H, s), 1.64(2H, m), 1.34(4H, m), 0.88(3H, t) 3400, 2940, 2860,1640,       1610, 1540,1500, 1460, 1380,1320, 1255, 1180, 1100,1005, 900, 845, 780      499(M.sup.+)379, 281,219, 181,169, 161,121, 105, 69 whitepowder  1(52)       ##STR118##       0.25(chloroform:methanol =       3:1) (CDCl.sub.3)7.75-8.15(3H, m), 7.10-7.40(4H, m),6.70-7.10(5H, m),      5.73(1H, m), 5.09(2H,s), 4.87(1H, dd), 4.47(1H, dd), 2.62(2H, t),1.60(2H,       m), 1.35(2H, m), 0.92(3H, t) 3410, 2930, 2860,1635, 1605, 1540,1500,      1455, 1380,1320, 1260, 1180,1100, 900, 840, 780 485(M.sup.+)421,      365,301, 267,219, 147,121, 105 whitepowder       1(53)             ##STR119##       0.50(methylenechloride:methanol = 5:1) 7.72(1H, d), 7.55(1H, d),      7.50(2H, d),6.90(1H, t), 6.89(2H, d), 6.73(1H, dd),6.59(1H, d), 5.80-5.68      (1H, m), 5.38-5.68(2H, m), 4.66(1H, dd), 4.54(1H, dd) 3700-2200,      1650,1600, 1540, 1510,1450, 1260, 1180,1100, 1030, 970,830, 780 461(M.sup      .+)436, 315,243, 219,217, 181,147 palegreenpowder       1(54)             ##STR120##       0.50(methylenechloride:methanol = 5:1) 7.89(2H, d), 7.30(1H, dd),      6.97(2H, d),6.90(1H, t), 6.77(1H, dd), 6.00-5.60(3H, m), 4.72(1H, dd),      4.60-4.50(3H, m) 3400, 3200-2300,1630, 1600, 1540,1500, 1450, 1250      435(M.sup.+)410, 315 whitepowder       1(55)             ##STR121##       0.44(methylenechloride:methanol = 5:1) 7.89(2H, dd), 7.31(1H, dd),      6.96(2H, dd),6.90(1H, t), 6.76(1H, dd), 5.98-5.78(1H, m), 5.78-5.72(1H,      m), 5.14-4.94(2H, m), 4.72(1H, dd), 4.55(1H, dd) 3700-2200, 1640,1610,      1550, 1510,1460, 1280, 1180,1100, 1050, 920,840, 780 407(M.sup.+)189,      147,121, 93 palegreypowder       1(56)             ##STR122##       0.30(methylenechloride:methanol = 5:1) 7.73(1H, d), 7.50(2H, d),      7.50(1H, d),6.91(2H, d), 6.90(1H, t), 6.75(1H, dd),6.58(1H, d), 5.95-5.60      (3H, m), 4.72-4.56(2H, m), 4.50(2H, d) 3350, 3100-2300,1660, 1600,      1540,1510, 1460, 1260 461(M.sup.+)315, 243,219, 147 whitepowder   1(57)       ##STR123##       0.51(methylenechloride:methanol = 5:1) 7.90(2H, dd), 7.31(1H, dd),      6.98(2H, dd),6.91(1H, t), 6.78(1H, dd), 5.98-5.60(3H, m), 4.74(1H, dd),      4.57(1H, dd),4.54(2H, dd) 3420, 2930, 3700-2200,1640, 1610, 1550,      1510,1460, 1320, 1260, 1180,1100, 1050, 970, 910,840, 780 477(M.sup.+)259      , 219,121, 69 palebrownpowder       1(58)             ##STR124##       0.51(methylenechloride:methanol = 3:1) (CDCl.sub.3)7.87(3H, m),      6.89(5H, m), 5.37(1H, m),4.94(1H, m), 4.51(1H, m), 4.01(2H, t),3.97(2H,      t) 3400, 1630, 1600,1530, 500, 1450,1310, 1250, 1170,1090, 1040, 840,770 4      71(M.sup.+)435, 253 whitepowder       1(59)             ##STR125##       0.5(methylenechloride:methanol = 3:1) (CDCl.sub. 3)7.86(3H, m),      6.86(5H, m), 5.76(1H, m),4.99(1H, m), 4.52(1H, m), 4.01(2H, t),3.53(2H,      t) 3400, 1630, 1600,1520, 1490, 1450,1250, 1170, 1100,1000, 840, 770      485(M.sup.+)4.49, 267 whitepowder       1(60)             ##STR126##       0.51(methylenechloride:methanol = 3:1) (CDCl.sub.3)7.86(3H, m),      6.89(5H, m), 5.76(1H, m),4.98(1H, m), 4.52(1H, m), 4.02(2H, t),3.53(2H,      t) 3400, 1630, 1600,1540, 1500, 1450,1320, 1260, 1170,1090, 1040,      840,770 499(M.sup.+)463, 281 whitepowder       1(61)             ##STR127##       0.45(chloroform:methanol = 3:1) (CDCl.sub.3)7.88(3H, m), 7.40(5H, m),      7.04-6.74(5H, m), 5.76(1H, m), 5.16(2H, s),5.00(1H, m), 4.52(1H, m)      3400, 1620, 1600,1530, 1490, 1450,1320, 1250, 1170,1090, 1000 429(M.sup.+      )309 white powder       1(62)             ##STR128##       0.5(chloroform:methanol = 3:1) 7.56(4H, m), 7.01-6.70(5H, m), 5.85(1H,      m), 4.60(2H, m), 4.01(2H, t),3.55(2H, t) 3400, 1650, 1590,1530, 1500,      1450,1250, 1170, 1090,960, 820 -- palebrownpowder       1(63)             ##STR129##       0.46(chloroformmethanol = 3:1) (CD.sub.3       OD)7.72-7.30(10H, m), 7.04-6.66(5H, m),5.80(1H, m), 5.23(2H, s),      4.56(2H, m) 3400, 1640, 1590,1490, 1440, 1240,1160, 1090, 990,810, 730      455(M.sup.+) whitepowder       1(64)             ##STR130##       0.30(methylenechloride:methanol = 3:1) 7.90(2H, d), 7.30(1H, d),      6.98(2H, d),6.92(1H, t), 6.78(1H, dd), 5.82-5.74(1H, m), 5.56-5.42(1H,      m), 5.14-5.04(1H, m) 3400, 2900, 3200- 2300, 1635, 1605,1545, 1505,      1      1460,260, 475(M.sup.+)355, 340,243, 219 whitepowder       1(65)             ##STR131##       0.58(methylenechloride:methanol = 5:1) 7.90(2H, dd), 7.32(1H, dd),      6.97(2H, dd),6.91(1H, t), 6.77(1H, dd), 5.96-5.60(4H, m), 5.10-4.86(2H,      m), 4.72(1H, dd),4.65-4.40(3H, m) 3600-2200, 1640, 1600,1550, 1510,      1460, 1380,1320, 1260, 1180, 1100,1050, 1000, 910, 840,780 447(M.sup.+)33      9, 229,219, 121,109, 93,69 whitepowder       1(66)             ##STR132##       0.30(methylenechloride:methanol = 5:1) 7.89(2H, dd), 7.30(1H, dd),      6.98(2H, dd),6.91(1H, t), 6.77(1H, dd), 6.04-5.60(3H, m), 4.73(1H, dd),      4.65-4.46(3H, m) 3700-2100, 1640, 1600,1550, 1510, 1460, 1380,1320,      1260, 1180, 1100,1050, 1000, 970, 900,840, 780 407(M.sup.+)219, 189, 149,       121,93, 69 whitepowder       1(67)             ##STR133##       0.33(methylenechloride:methanol = 5:1) 7.73(1H, d), 7.48(2H, d),      7.48(2H, d),6.88(2H, d), 6.89(1H, t), 6.74(2H, dd),6.57(1H, d) -- --      whitepowder       1(68)             ##STR134##       0.47(methylenechloride:methanol = 5:1) 7.89(2H, dd), 7.30(1H, dd),      6.96(2H, dd),6.91(1H, t), 6.77(1H, dd), 5.77(1H, s),4.74(1H, dd),      4.55(1H, dd), 4.02(2H, t) 3700-2200, 2960, 1640,1610, 1540, 1510,      1460,1390, 1320, 1260, 1180,1100, 1040, 900, 840,780, 720 437(M.sup.+)219      , 149,121, 93,69 whitepowder       1(69)             ##STR135##       0.37(chloroform:methanol = 4:1) 7.67(1H, d), 7.49(2H, d), 7.28(2H,      d),6.90(1H, t), 6.74(1H, d), 5.72(1H, dd), 4.67(1H, dd), 4.46(1H, dd),      2.62(2H, t),1.59(2H, m), 1.28(6H, m), 0.86(3H, t) 3600-2400, 2210,1610,      1590, 1540,1460, 1330, 1260,1090, 1040, 940,820, 770 431(M.sup.+)219,213 y      ellowpowder       1(70)             ##STR136##       0.31(methylenechloride:methanol = 5:1) 7.93(1H, d), 7.58(2H, d),      7.58(1H, d),6.90(2H, d), 6.89(1H, t), 6.74(1H, dd),6.54(1H, d) 3300,      3200-2300,1650, 1595, 1540,1505 447(M.sup.+)301, 245 whitepowder  1(71)       ##STR137##       0.37(methylenechloride:methanol = 5:1) 7.89(2H, dd), 7.30(1H, dd),      6.97(2H, dd),6.91(1H, t), 6.77(1H, dd), 6.00-5.60(3H, m), 4.73(1H, dd),      4.56(1H, dd),4.52(2H, d) 3700-2200, 1640, 1600,1550, 1510, 1460,      1380,1320, 1260, 1180, 1100,1050, 1000, 970, 910,840, 780, 720 393(M.sup.      +)339, 219,179, 149,121, 93 white powder       1(72)             ##STR138##       0.35(methylenechloride:methanol = 5:1) 7.69(1H, d), 7.50(1H, d),      7.40(2H, d),6.88(2H, d), 6.86(1H, t), 6.70(1H, dd),6.55(1H, d) 3350,      3200-2300,1650, 1600, 1530,1500, 1450, 1255 433(M.sup.+)287, 215      paleyellowpowder       1(73)             ##STR139##       0.30(methylenechloride:methanol = 5:1) 7.73(1H, d), 7.50(1H, d),      7.48(2H, d),6.88(2H, d), 6.89(1H, t), 6.74(1H, dd),6.58(1H, d) 3350,      3200-2300,1650, 1595, 1530,1505, 1450, 1270 433(M.sup.+)215 paleyellowpow      der       1(74)             ##STR140##       0.20(chloroform:methanol =       4:1) 7.85(2H, d), 7.10-7.40(6H, m), 6.92(2H,d), 6.84(1H, d), 6.73(1H,      d), 5.72(1H, m),4.75(1H, dd), 4.50(1H, dd), 4.21(2H, t),3.11(2H, t)      3420, 3240, 3030, 2950,2870, 2740, 1605, 1535,1500, 1460, 1250, 1170,1095      , 1040, 1020, 910,840, 765 443(M.sup.+)408, 225,201, 131,121, 10584      p      whiteowder       1(75)             ##STR141##       0.20(chloroform:methanol = 4:1) 7.70(1H, d), 7.40(2H, d), 7.15-7.40(6H,      m), 6.75-6.90(3H, m), 6.68(1H, d),6.50(1H, d), 5.68(1H, m), 4.45-4.80(2H,       m), 4.15(2H, t), 3.08(2H, t) 3400, 3040, 2870,1660, 1605, 1540,1510,      1450, 1260,1200, 1175, 1100,1020, 965, 830, 700, 469(M.sup.+)433,      251,215, 147,105 paleyellowpowder       1(76)             ##STR142##       0.20(chloroform:methanol = 4:1) (CDCl.sub.3)8.00(1H, s), 7.86(2H, d),      7.10-7.40(5H, m), 6.70-7.00(5H, m), 5.74(1H, m),4.88(1H, dd), 4.50(1H,dd)      , 4.02(2H, m),2.70(2H, m), 1.85(4H, m) 3400, 3030, 2950,1635, 1605,      1540,1505, 1460, 1260,1175, 1095, 840,770, 700, 471(M.sup.+)253, 121,91      whitepowder       1(77)             ##STR143##       0.20(chloroform:methanol = 4:1) 7.70(1H, d), 7.45(2H, d), 7.10-7.55(6H,      m), 6.80-6.95(3H, m), 6.71(1H, d),6.56(1H, d), 5.70(1H, m), 4.45-4.80(2H,       m), 3.97(2H, m), 2.70(2H, m),1.80(4H, m) 3350, 3030, 2950,2870, 1660,      1600,1540, 1510, 1450,1260, 1200, 1175,1105, 970, 830, 780 497(M.sup.+)27      9, 219,147, 91 paleyellowpowder       1(78)             ##STR144##       0.20(chloroform:methanol = 4:1) (CDCl.sub.3)7.97(1H, s), 7.89(2H, d),      7.03(2H, d),6.70-7.00(3H, m), 5.75(1H, m), 4.90(1H,dd), 4.73(2H, m),      4.49(1H, dd), 2.22(2H,t), 1.62(1H, m), 1.40(2H, m), 0.87(6H, d) 3400,      2960, 1635,1605, 1540, 1500,1460, 1260, 1230,1175, 1095, 1000,840, 775      447(M.sup.+)279, 229,147, 121,91 whitepowder       1(79)             ##STR145##       0.45(methylenechloride:methanol = 5:1) 7.75(1H, d), 7.51(2H, d),      7.51(1H, d),6.92(2H, d), 6.91(1H, t), 6.76(1H, dd),6.60(1H, d), 6.00-5.62      (3H, m), 4.74-4.44(4H, m) 3700-2200, 1660, 1600,1550, 1520, 1490,      1460,1260, 1180, 1100, 1050,970, 920, 830, 780,720 419(M.sup.+)219,      201,147, 105 paleyellowpowder       1(80)             ##STR146##       0.33(methylenechloride:methanol = 5:1) 7.72(1H, d), 7.48(2H, d),      7.44(1H, d),6.89(2H, d), 6.88(1H, t), 6.73(1H, dd),6.55(1H, d), 6.00-5.60      (3H, m), 4.70-4.56(2H, m), 4.48(2H, d) 3350, 3200-2300,1650, 1590,      1530,1500, 1440, 1250 503(M.sup.+)357 whitepowder       1(81)             ##STR147##       0.34(methylenechloride:methanol = 5:1) 7.88(2H, d), 7.32(1H, dd),      6.95(2H, d),6.90(1H, t), 6.76(1H, dd), 5.80-5.72(1H, m), 4.70(1H, dd),      4.55(1H, dd),4.01(2H, t) 3400, 3200-2300,1630, 1600, 1540,1500, 1460,      1250 451(M.sup.+)233121 whitepowder       1(82)             ##STR148##       0.30(methylenechloride:methanol = 5:1) 7.75(1H, d), 7.50(2H, d),      7.45(1H, d),7.36-7.15(5H, m), 6.91(1H, t), 6.89(2H,d), 6.76(1H, dd),      6.66(1H, d), 5.75(1H,t), 4.63(2H, d), 3.98(2H, t) 3350, 3100-2250,1660,      1600, 1540,1510, 1450, 1260 511(M.sup.+)293251219 whitepowder  1(83)       ##STR149##       0.35(methylenechloridemethanol = 5:1) 7.87(2H, d), 7.36-7.11(6H, m),      6.94(2H, d), 6.80(1H, t), 6.76(1H, dd), 5.75(1H,dd), 4.72(1H, dd),      4.55(1H, dd),4.00(2H, t) 3400, 3100-2250,1630, 1600, 1540,1505, 1450,      1300,1260 485(M.sup.+)267 whitepowder       1(84)             ##STR150##       0.45(methylenechloridemethanol = 5:1) 7.88(2H, d), 7.32(1H, dd),      6.95(2H, d),6.90(1H, t), 6.76(1H, dd), 5.76(1H, t),4.75-4.50(2H, m),      4.01(2H, t) 3440, 2930, 2850,1640, 1610, 1550,1510, 1460, 1260 477(M.sup.      +)259231 whitepowder       1(85)             ##STR151##       0.32(methylenechloridemethanol = 5:1) 7.72(1H, d), 7.48(2H, d),      7.44(1H, d),6.88(1H, t), 6.87(2H, d), 6.73(1H, dd),6.57(1H, d), 5.71(1H,      m), 4.68-4.51(2H, m), 3.97(2H, d) 3430, 2930, 2850,1660, 1600, 1540,1510,       1450, 1260 503(M.sup.+)285 yellowpowder       1(86)             ##STR152##       0.30(methylenechloride:methanol = 5:1) 7.72(1H, d), 7.48(2H, d),      6.88(1H, t),6.87(2H, d), 6.73(1H, dd), 6.56(1H, d),0.87(6H, d) 3350,      3200-2300,1655, 1600, 1540,1510, 1450, 1260 477(M.sup.+)259 paleyellowpow      der       1(87)             ##STR153##       0.32(methylenechloride:methanol = 5:1) 7.89(2H, d), 7.27(1H, dd),      6.96(2H, d),6.90(1H, t), 6.77(1H, dd), 5.70-5.30(2H, m) 3400, 3200-2300,1      640, 1605, 1545,1500, 1450, 1260 449(M.sup.+)369231 whitepowder  1(88)       ##STR154##       0.32(methylenechloride:methanol = 5:1) 7.89(2H, d), 7.44(2H, d),      7.38(1H, dd),6.91(1H, t), 6.77(1H, dd), 4.55(2H, s) 3350, 3200-2300,1630,       1605, 1535,1450, 1090 437(M.sup.+)287219 whitepowder       1(89)             ##STR155##       0.45(methylenechloride:methanol = 5:1) 7.89(2H, d), 7.36(1H, d),      6.94(2H, d),6.91(1H, t), 6.76(1H, d), 3.68(3H, s) 3325, 3200-2300,1730,      1640, 1610,1460, 1260 467(M.sup.+)391, 322 whitepowder       1(90)             ##STR156##       0.45(methylenechloride:methanol = 5:1) 7.82(2H, d), 7.41(1H, dd),      7.32(2H, d),6.91(1H, t), 6.76(1H, d), 2.97(2H, t) 3400, 3200-2300,1645,      1620, 1605,1550, 1460, 1100, 453(M.sup.+)302, 235 whitepowder  1(91)       ##STR157##       0.38(methylenechloride:methanol = 5:1) 7.76(1H, d), 7.52(2H, d),      7.34(2H, d),6.88(1H, t), 6.73(1H, dd), 6.70(1H, d),4.50(2H, s), 3.50(2H,      t), 0.90(6H, d) 3370, 3200-2300,1660, 1610, 1545,1460, 1260, 1100      449(M.sup.+ )245, 231,219 whitepowder       1(92)             ##STR158##       0.34(methylenechloride:methanol = 5:1) 7.72(1H, d), 6.49(2H, d),      7.17(1H, dd),6.00-6.80(6H, m), 6.74(1H, dd), 6.57(1H, d), 4.21(2H, t),      3.32(2H, t) 3350, 3200-2300,1660, 1610, 1540,1510, 1460, 1260,1180, 830      475(M.sup.+)365, 257,219 whitepowder       1(93)             ##STR159##       0.33(methylenechloride:methanol = 5:1) 7.50(1H, s), 7.58(1H, d),      7.37(2H, d),6.93(2H, d), 6.84(1H, t), 6.84-6.74(2H, m), 5.80(1H, m),      2.38(3H, d),0.92(6H, d) 3400, 3200-2300,1635, 1600, 1505,1260 463(M.sup.+      )245, 161 whitepowder       1(94)             ##STR160##       0.33(methylenechloride:methanol = 5:1) 7.87(2H, d), 7.41(1H, dd),      6.94(2H, dd),6.90(1H, t), 6.74(1H, dd), 4.04(2H, t) 3350, 3200-2300,1630,       1600, 1540,1500, 1450, 1245 449(M.sup.+)406, 393,355, 231 whitepowder      1(95)       ##STR161##       0.34(methylenechloride:methanol = 5:1) 7.88(2H, dd), 7.35(1H, dd),      7.17(1H, dd),7.01-6.84(5H, m), 6.75(1H, dd),5.80-5.72(1H, m), 4.68(1H,      dd), 4.55(1H, dd) 3700-2200, 1640,1610, 1540, 1500,1470, 1260, 1180,1100,       900, 840,700 449(M.sup.+)355, 231,219, 149,121, 111 whitepowder  1(96)       ##STR162##       0.35(methylenechloride:methanol = 5:1) 7.88(2H, dd), 7.34(1H, dd),      6.94(2H, dd),6.90(1H, t), 6.76(1H, dd), 5.80-5.72(1H, m), 4.69(1H, dd),      4.55(1H, dd) 3600-2200, 1740,1640, 1600, 1550,1510, 1460, 12601180,      1100, 1040,850, 780 481(M.sup.+)263, 219,149, 121 whitepowder  1(97)       ##STR163##       0.41(methylenechloride:methanol = 5:1) 7.73(1H, d), 7.47(2H, d),      7.38(1H, d),6.87(1H, t), 6.86(2H, d), 6.73(1H, dd),4.06(2H, t) 3600-2200,       1740,1660, 1600, 1540,1520, 1460, 1260,1180, 1100, 1040,970, 830      507(M.sup.+)464, 289,219, 121 paleyellowpowder       1(98)             ##STR164##       0.30(methylenechloride:methanol = 5:1) 7.72(2H, d), 7.46(1H, d),      6.84(2H, d),6.87(1H, t), 6.72(1H, dd), 6.55(1H, d),5.80-5.66(1H, m),      4.80-4.50(2H, m) 3400, 3200-2300,1655, 1600, 1530,1510, 1450, 1260      475(M.sup.+)381, 223,257, 147 paleyellowpowder        1(99)             ##STR165##       0.41(methylenechloride:methanol = 5:1) 7.89(2H, d), 7.34(1H, dd),      6.96(2H, d),6.91(1H, t), 6.77(1H, dd), 4.02(2H, t) 3410, 3150-2250,1640,      1610, 1540,1510, 1460, 1260 449(M.sup.+)231 whitepowder       1(100)             ##STR166##       0.33(methylenechloride:methanol = 5:1) 7.79(2H, dd), 7.37(1H, dd),      7.35-7.15(5H, m), 6.95(2H, dd), 6.92(1H, t),6.78(1H, dd), 5.82-5.73(1H,      m) 3600-2200, 1630,1600, 1550, 1520,1470, 1330, 1270,1190, 1100,      1040,850, 780, 710 457(M.sup.+)239, 219,121 whitepowder       1(101)             ##STR167##       0.33(methylenechloridemethanol = 5:1) 7.96(2H, d), 7.52(1H, dd),      7.22(2H, d),7.25-7.14(1H, m), 6.93(1H, t), 6.78(1H, dd), 6.03(1H, d),      5.90-5.70(1H,m), 4.80-4.50(2H, m) 3400, 3200-2300,1730, 1630, 1595,1530,      1200 463(M.sup.+)339, 245,121, 125 whitepowder       1(102)             ##STR168##       0.48(methylenechloridemethanol = 5:1) 7.89(2H, dd). 7.38(1H, dd),      6.96(2H, dd),6.91(1H, t), 6.76(1H, dd), 5.81-5.73(1H, m), 4.69(1H, dd),      4.56(1H, dd) 3600-2100, 2950,1640, 1600, 1550,1510, 1460, 1320,1260,      1180, 1100,1050, 850 479(M.sup.+)261, 219,121, 93 whitepowder  1(103)       ##STR169##       0.27(methylenechloridemethanol = 5:1) 7.72(1H, d), 7.50(2H, d),      7.30-7.14(5H,m), 6.90(1H, t), 6.88(2H, d), 6.74(1H,dd), 6.59(1H, d),      5.78-5.68(1H, m),4.68(1H, dd), 4.53(1H, dd) 3700-2100, 1660,1600, 1540,      1510,1450, 1270, 1180,1100, 1030, 980,830, 700 483(M.sup.+)265, 219,147,      119,91 paleyellowpowder       1(104)             ##STR170##       0.25(methylenechloridemethanol = 4:1) (CDCl.sub.3)8.00(1H, s), 7.87(2H,      d), 7.33(2H, d),7.20(2H, d), 7.02(2H, d), 6.98(1H, d),6.86(1H, t),      6.75(1H, d), 5.74(1H, m),5.10(2H, s), 4.86(1H, dd), 4.48(1H, dd) 3300,      2960, 2870,1620, 1605, 1500,1465, 1250, 1175,1100 471(M.sup.+), 428415,      377, 351339, 253, 223219, 205, 149133, 121, 91 whitepowder  1(105)       ##STR171##       0.35(methylenechloridemethanol = 5:1) 7.91(1H, d), 7.45-7.20(6H, m),      7.02(2H,d), 6.91(1H, t), 6.76(1H, dd), 6.74(1H,d), 6.39(1H, dt) 3400,      3200-2300,1630, 1600, 1540,1495, 1450, 1250 455(M.sup.+)335, 281      paleyellowpowder       1(106)             ##STR172##       0.32(methylenechloride:methanol = 5:1) 8.06(4H, s), 7.72(1H, dd),      6.97(1H, t),6.80(1H, dd), 5.76(1H, m), 4.65(2H, m),3.00(2H, t) 3300,      3200-2300,1680, 1630, 1530,1460, 1275 449(M.sup.+)299, 231 whitepowder      1(107)       ##STR173##       0.20(chloroform:methanol = 4:1) (CDCl.sub.3)8.03(1H, s), 7.35-7.60(5H,      m), 7.15(1H,s), 6.96(2H, d), 6.60-6.70(5H, m), 5.80(1H, m), 4.97(1H,      dd), 4.49(1H, dd),3.89(2H, t) 3390, 2950, 1655,1605, 1540, 1510,1450,      1260, 1175 525(M.sup.+)307, 279,195, 165,121 yellowpowder  1(108)       ##STR174##       0.25(methylenechloride:methanol = 5:1) 7.88(2H, d), 7.33(1H, dd),      7.34-7.10(5H, m), 6.94(2H, d), 6.90(1H, t), 6.75(1H, dd), 4.12(2H, t)      3460-2210, 1640,1610, 1540, 1510,1460, 1260 489(M.sup.+)271 whitepowder      1(109)       ##STR175##       0.20(chloroform:methanol = 5:1) (CDCl.sub.3)8.05(1H, s), 7.86(2H, d),      7.13(1H, dd),6.65-7.05(7H, m), 5.74(1H, m), 4.85(1H,dd), 4.49(1H, dd),      4.03(2H, m), 2.93(2H, m), 1.90(4H, m) 2950, 1630, 1605,1540, 1500,      1455,1255, 1175, 1090,840, 770, 690 477(M.sup.+)307, 259,139, 121,97     y      paleellowpowder       1(110)             ##STR176##       0.20(chloroform:methanol = 4:1) (CDCl.sub.3)7.96(1H, s), 7.85(2H, d),      7.10-7.35(3H,m), 6.70-7.00(7H, m), 5.72(1H, m), 4.86(1H, dd), 4.47(1H,      dd), 4.20(2H, t),4.14(2H, t), 2.28(2H, m) 3400, 2940, 2870,2730, 1630,      1600,1540, 1490, 1460,1250, 1175, 1095, 1050, 760, 690 473(M.sup.+)255,      135,121, 107 whitepowder       1(111)             ##STR177##       0.30(methylenechloride:methanol = 5:1) 7.88(2H, d), 6.97(3H, d),      6.88(1H, t),6.77(1H, dd), 6.35(1H, dd), 6.07(1H,dd), 5.86-5.65(3H, m),      4.85(1H, dd),4.60(2H, d), 4.52(1H, dd) 3400, 2960, 2930,2860, 1600,      1      1530,500, 1450, 1380,1250 447(M.sup.+)327, 229,219 whitepowder  1(112)       ##STR178##       0.20(chloroform:methanol = 4:1) (CDCl.sub.3)7.94(1H, s), 7.87(2H, d),      6.70-7.00(5H,m), 5.74(1H, m), 4.90(1H, dd), 4.48(1H,dd), 4.02(2H, t),      3.30(2H, t), 1.10-2.20(7H, m) 3410, 2940, 2870,2730, 2090, 1635,1600,      1540, 1505,1460, 1260, 1180,1095, 845, 770 450(M.sup.+)232, 121,84      whitepowder       1(113)             ##STR179##       0.43(methylenechloride:methanol = 5:1) 7.89(2H, d), 7.39(1H, dd),      6.96(2H, d),6.91(1H, t), 6.76(1H, dd), 4.04(2H, t) 3650-3150, 2940,1630,      1605, 1545,1505, 1460, 1260 (M.sup.+)487269 whitepowder       1(114)             ##STR180##       0.22(methylenechloride:methanol = 5:1) 7.87(2H, d), 7.42(1H, dd),      7.36-7.20(5H, m), 6.90(2H, d), 6.90(1H, t),6.76(1H, dd), 4.19(2H, t),      3.30(2H, t) 3400, 3100-2200,1600, 1540, 1500,1460, 1250 475(M.sup.+)257      whitepowder       1(115)             ##STR181##       0.30(methylenechloride:methanol = 5:1) 7.92(2H, d), 7.38(1H, d),      7.30(2H, t),7.10-6.87(6H, m), 6.77(1H, dd), 5.77(1H, dd), 4.70(1H, dd),      4.56(1H, dd),4.37(4H, s) 3600-2500, 1730,1630, 1605, 1570,1530, 1485,      1460,1380, 1285, 1245,1200 459(M.sup.+)241, 218 yellowpowder  1(116)       ##STR182##       0.31(methylenechloride:methanol = 5:1) 7.89(2H, d), 7.41(1H, dd),      6.95(2H, d).6.91(1H, t), 6.75(1H, dd), 4.50(2H, t),4.07(2H, t) 3350,      2900, 1630,1605, 1540, 1505,1460, 1260 decom-posed whitepowder  1(117)       ##STR183##       0.30(methylenechloride:methanol = 5:1) 7.92(2H, d), 7.46(1H, dd),      7.00(2H, d),6.92(1H, t), 6.76(1H, dd), 5.76(1H, dd),4.64(1H, dd),      4.56(1H, dd), 4.21 (2H, t) 3650-3150, 3020-2250,2100, 1635, 1605,1540,      1510, 1480,1460, 1340, 1320,1310, 1280, 1260 408(M.sup.+)339, 190      whitepowder       1(118)             ##STR184##       0.30(methylenechloride:methanol = 5:1) 7.90(2H, d), 7.34(1H, dd),      6.95(2H, d), 6.92(1H, t), 6.77(1H, dd), 5.77(1H, dd),4.70(1H, dd),      4.56(1H, dd), 4.06(2H, t),3.39(2H, t) 3620-3150, 2920,2100, 1605,      1540,1505, 1460, 1260 436(M.sup.+)218 whitepowder       1(119)             ##STR185##       0.30(methylenechloride:methanol =       5:1) 7.86(2H, d), 7.80(3H, m),7.72(1H, s), 7.58(1H, dd),7.44(3H, m),      6.95(2H, d),6.90(1H, t), 6.73(1H, dd),5.68(1H, t), 4.55(2H, d) 3700-2300,       1650,1610, 1520, 1510,1455, 1260 493(M.sup.+),450, 437,399, 275      whitepowder       1(120)             ##STR186##       0.30(methylenechloride:methanol = 5:1)   491(M.sup.+)273, 115111      whitepowder       1(121)             ##STR187##       0.30(methylenechloride: methanol = 5:1)   505, 411,287, 253,121      whitepowder

EXAMPLE 1(201)-1(260)

By the same procedure as example 1, using with a corresponding carboxylic acid and a corresponding 8-amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran hydrochloride which have corresponding substituent R³, following compounds having the following physical data, shown in table [IX] were given. ##STR188##

    TABLE IX        Substituent R, R.sup.3 Rf value in TLC     Example in the general      (developing No. formula (In) solvent) NMR (δppm) IR (νcm.sup.-1)       Mass Appearance               1(201)       0.26(chloroform:methanol =3:1) 8.81(1H, dd), 7.95(1H, dd), 7.76(1H,      d)7.57(2H, d), 7.52(1H, t), 7.28(1H, s),7.25(2H, d), 7.10(1H, d),      2.66(2H, t),1.66(2H, m), 1.20-1.50(4H, m),0.91(3H, t) 3310, 3060, 2980,      2850,1620-1650, 1585, 1520,1420, 1350, 1280, 1205,1180, 1085, 1005,      970,880, 810, 750 429(M.sup.+)401, 391, 386,375, 296, 229,201, 131, 115      pale brown powder       1(202)             ##STR189##       0.16(chloroform:methanol =4:1) 8.72(1H, d), 7.76(1H, d), 7.72(1H,      m)7.56(2H, d), 7.24(2H, d), 7.24(1H, s),7.10(1H, d), 2.65(2H, t),      2.52(3H, s),1.65(2H, m), 1.20-1.45(4H, m),0.90(3H, t) 3400, 2980, 2860,      1650,1625, 1600, 1585, 1470,1420, 1370, 1330, 1265,1215, 1180, 1080,     8      980,95, 860 448(M.sup.+)415, 400,243, 201,181 yellow powder  1(203)       ##STR190##       0.20(chloroform:methanol =4:1) 8.80(1H, dd), 7.80(1H, d), 7.50-7.65(3H,      m), 726(1H, s), 7.24(2H, d), 7.14(1H, d), 2.65(2H, t), 1.65(2H, m),1.20-1      .45(4H, m), 0.90(3H, t) 3400, 2980, 2850, 1650,1620, 1500, 1520,      1470,1420, 1375, 1325, 1175 419, 404,296, 247,201, 161,131, 115 yellow      brown powder       1(204)             ##STR191##       0.15(chloroform:methanol =4:1) 8.80(1H, dd), 7.90(1H, dd), 7.76(1H,      d)7.55-7.70(2H, m), 7.50(1H, t),7.35-7.50(3H, m), 7.27(1H, s),7.12(1H,      d) 3400, 3020, 1695, 1635,1610, 1585, 1520, 1420,1355, 1280, 1185,      1160,880, 760, 550 359(M.sup.+)331, 316,296, 268,229, 201,131, 108      yellow powder       1(205)             ##STR192##       0.46(methylenechloride:methanol =4:1) 8.74(1H, dd), 7.99(1H, dd),      7.97(2H, d)7.54(1H, t), 7.88(2H, d), 7.26(1H, s),2.78(2H, t), 0.92(3H,      t) 3500-2300, 1670, 1620,1590, 1535, 1435 408(M.sup.+)349, 175 white      powder       1(206)             ##STR193##       0.46(chloroform :methanol =3:1) 8.66(1H, dd), 8.02(2H, d), 7.98(1H,      dd), 7.53(1H, t), 7.27(1H, s), 7.05(2H, d), 4.08(2H, t), 1.90-1.76(2H,      m),1.64-1.44(2H, m), 1.02(3H, t) 3600-2300, 1645, 1600,1585, 1580, 1505,      1425,1385, 1290, 1255, 1180,1070, 1030, 970, 890, 840, 810, 765 405(M.sup      .+)225, 177 pale yellow powder       1(207)             ##STR194##       0.46(chloroform:methanol =3:1) 8.60(1H, dd), 8.02(2H, d), 7.98(1H,dd),      7.54(1H, t), 7.27(1H, s), 7.05(2H, d), 4.08(2H, t), 1.94-1.78(2H,      m),1.60-1.25(4H, m), 0.96(3H, t) 3600-2300, 1645, 1600,1585, 1530, 1505,      1425,1385, 1290, 1255, 1180,1070, 1030, 970, 890,840, 810, 765 419(M.sup.      +)239, 191 pale yellow powder       1(208)             ##STR195##       0.48(chloroform:methanol =3:1) 8.45(1H, dd), 8.02(2H, d), 7.98(1H,dd),      7.53(1H, t), 7.22(1H, s), 7.05(2H, d), 4.07(2H, t), 1.90-1.75(2H,      m),1.60-1.30(6H, m), 1.00-0.90(3H, t) 3600-2300, 1645, 1600,1585, 1530,      1505, 1425,1385, 1290, 1255, 1180,1070, 1030, 970, 890,840, 810, 765      433(M.sup.+ )379, 205 white powder       1(209)             ##STR196##       0.48(chloroform:methanol =3:1) 8.48(1H, dd), 8.02(2H, d), 7.98(1H,dd),      7.54(1H, t), 7.24(1H, s), 7.04(2H, d), 4.07(2H, t), 1.90-1.75(2H,      m),1.60-1.25(8H, m), 1.00-0.75(3H, t) 3600-2300, 1645, 1600,1585, 1530,      1505, 1425,1385, 1290, 1255, 1180,1070, 1030, 970, 890,840, 810, 765      447(M.sup.+)394, 219 pale yellow powder       1(210)             ##STR197##       0.48(chloroform:methanol =3:1) 8.70(1H, dd), 8.01(2H, d), 7.97(1H,dd),      7.52(1H, t), 7.26(1H, s), 7.03(2H, d), 4.06(2H, t), 1.90-1.76(2H,      m),1.60-1.20(12H, m), 0.96-0.84(3H, t) 3600-2300, 1645, 1600,1585, 1530,      1505, 1425,1385, 1290, 1255, 1180,1070, 1030, 970, 890,840, 810, 765      475(M.sup.+)421, 247 pale yellow powder       1(211)             ##STR198##       0.48(chloroform:methanol =5:1) 8.48(1H, dd), 8.02(2H, d), 7.98(1H,      d),7.53(1H, t), 7.27(1H, s), 7.04(2H, d),4.06(2H, t), 1.90-1.75(2H,      m),1.60-1.20(10H, m), 1.00-0.75(3H, t) 3600-2300, 1645, 1600,1585, 1530,      1505, 1425,1385, 1290, 1255, 1180,1070, 1030, 970, 890,840, 810, 765      461(M.sup.+)407, 233 pale yellow powder       1(212)             ##STR199##       0.30(methylenechloride:methanol =4:1) 8.74(1H, dd), 8.01(2H, d),      7.96(1H,dd), 7.52(1H, t), 7.24(1H, s), 7.05(2H, d), 6.00-5.64(3H, m),      5.10-4.90(2H, m), 4.58(2H, brd) 3275, 3075, 3500-2300,1650, 1630, 1600,      1570,1510, 1495, 1420, 1250 457(M.sup.+)337, 229121 pale brown powder      1(213)       ##STR200##       0.30(methylenechloride:methanol =4:1) 8.66(1H, dd), 8.02(2H, d),      7.96(1H,dd), 7.53(1H, t), 7.26(1H, s), 7.06(2H, d), 5.60-5.44(1H, m),      5.20-5.00(1H, m) 3275, 3050, 3500-2300,1640, 1590, 1570, 1510,1490,      1415, 1240 485(M.sup.+)365, 350231 pale brown powder       1(214)             ##STR201##       0.44(chloroform:methanol =4:1) 8.91(1H, dd), 7.94(1H, dd), 7.76(1H,d),      7.58(2H, d), 7.50(1H, t), 7.24(1H,s), 6.99(1H, d), 6.94(2H, d), 4.01(2H,t      ), 1.90-1.74(2H, m), 1.60-1.30(6H, m),0.92(3H, t) 3600-2300, 1640,      1600,1535, 1430, 1390, 1355,1190, 1170, 1110, 825,755 459(M.sup.+)231      pale yellow powder       1(215)             ##STR202##       0.44(chloroform:methanol =4:1)  8.82(1H, dd), 7.94(1H, dd), 7.74(1H,d),      7.61(2H, d), 7.52(1H, t), 7.28(1H,s), 7.04(1H, d), 6.96(2H, d), 4.04(2H,t      ), 1.90-1.76(2H, m), 1.60-1.26(8H, m),0.92(3H, t) 3600-2300, 1640,      1600,1535, 1430, 1390, 1355,1335, 1260, 1190, 1170,1110, 1070, 1040,      1010,975, 825, 755 473(M.sup.+)245 pale yellow powder       1(216)             ##STR203##       0.42(chloroform:methanol =4:1) 8.84(1H, dd), 7.95(1H, dd), 7.75(1H,d),      7.60(2H, d), 7.52(1H, t), 7.29(1H, s), 7.04(1H, d), 6.96(2H, d),      4.02(2H, t), 1.90-1.76(2H, m), 1.72-1.56(1H, m), 1.46-1.24(4H, m),      0.96(6H, d) 3600-2300, 1640, 1600,1535, 1430, 1360, 1260,1170, 1040,      1010, 825,755 459(M.sup.+)261, 231 pale yellow powder       1(217)             ##STR204##       0.43(chloroform:methanol =4:1) 8.88(1H, dd), 7.94(1H, dd), 7.75(1H,d),      7.49(2H, d), 7.50(1H, t), 7.26(1H,s), 7.02(1H, d), 6.93(2H, d), 4.04(2H,t      ), 3.59(2H, t), 1.96-1.89(4H, m),1.86-1.60(2H, m) 3600-2300, 1645,      1600,1530, 1430, 1390, 1260,1170, 1110, 1070, 1040,1010, 975, 825, 755      443425, 251 yellow powder       1(218)             ##STR205##       0.43(chloroform:methanol =4:1) 8.86(1H, dd), 7.94(1H, dd), 7.74(1H,d),      7.59(2H, d), 7.51(1H, t), 7.26(1H,s), 7.03(1H, d), 6.96(2H, d), 4.04(2H,t      ), 3.58(2H, t), 1.94-1.86(4H, m),1.60-1.50(4H, m) 3600-2300, 1645,      1600,1530, 1430, 1370, 1360,1260, 1170, 1110, 1070,1040, 1010, 975,      825,755 493(M.sup.+)457, 439265 yellow powder       1(219)             ##STR206##       0.43(chloroform:methanol =4:1) 8.86(1H, dd), 7.96(1H, dd), 7.78(1H,d),      7.56(2H, d), 7.52(1H, t), 7.28(1H,s), 7.25(2H, d), 7.14(1H, d), 2.68(2H,t      ), 1.72-1.56(2H, m), 1.48-1.26(2H, m),0.96(3H, t) 3600-2300, 1640,      1585,1520, 1430, 1380, 1350,1280, 1180, 1110, 1070,1040, 1010, 975,      890,820, 755 415(M.sup.+)231, 187 pale brown powder       1(220)             ##STR207##       0.43(chloroform:methanol =4:1) 8.86(1H, dd), 7.95(1H, dd), 7.78(1H,d),      7.57(2H, d), 7.52(1H, t), 7.28(1H,s), 7.24(2H, d), 7.11(1H, d), 2.66(2H,t      ), 1.74-1.56(2H, m), 1.44-1.24(6H, m),0.89(3H, t) 3600-2300, 1640,      1590,1520, 1425, 1385, 1350,1280, 1080, 1110, 1065,1040, 1005, 975,      890,820, 755 443(M.sup.+)215 white powder       1(221)             ##STR208##       0.43(chloroform:methanol =4:1) 8.84(1H, dd), 7.95(1H, dd), 7.76(1H,d),      7.58(2H, d), 7.52(1H, t), 7.28(1H,s), 7.20(2H, dd), 7.14(1H, d),      2.65 (2H, t), 1.74-1.58(2H, m), 1.40-1.20(8H, m), 0.88(3H, t) 3500-2300,      1640, 1585,1520, 1430, 1350, 1180,1110, 1040, 1005, 975,885 457(M.sup.+)2      29 white powder       1(222)             ##STR209##       0.30(methylenechloride:methanol =4:1) 8.72(1H, dd), 8.00(2H, dd),      7.95(1H,dd), 7.50(1H, t), 7.23(1H, s), 7.04(2H, d), 6.00-5.60(2H, m),      4.56(2Hbrd) 3300, 3500-2300, 1640,1595, 1570, 1515, 1490,1415, 1240      473(M.sup.+)353, 245121 brown powder       1(223)             ##STR210##       0.30(methylenechloride:methanol =4:1) 8.74(1H, dd), 8.02(2H, d),      7.96(1H,dd), 7.50(1H, t), 7.23(1H, s), 7.10(2H, d), 4.77(2H, t) 3375,      3050, 3500-2300,1640, 1590, 1570, 1510,1490, 1415, 1240 457(M.sup.+)429,      229175, 121 pale brown powder       1(224)             ##STR211##       0.41(methylenechloride:methanol =4:1) 8.65(1H, dd), 8.01(2H, d),      7.96(1H,dd), 7.52(1H, t), 7.25(1H, s), 7.04(2H, d), 4.16-4.06(2H, m),      3.70-3.60(2H, m), 2.10-1.96(4H, m) 3600-2300, 1650, 1600,1585, 1530,      1505, 1430,1380, 1295, 1255, 1180,1115, 1070, 1035, 890,845, 815, 765,      750 211 white powder       1(225)             ##STR212##       0.41(methylenechloride:methanol =4:1) 8.62(1H, dd), 8.02(2H, d),      7.98(1H,dd), 7.53(1H, t), 7.26(1H, s), 7.05(2H, d), 4.10(2H, t),      3.60(2H, t),2.00-1.80(4H, m), 1.80-1.60(2H, m) 3600-2300, 1650, 1600,1585      , 1530, 1505, 1430,1380, 1295, 1255, 1180,1115, 1070, 1035, 895,845,      815, 765, 760 453(M.sup.+)417, 225 white powder       1(226)             ##STR213##       0.44(methylenechloride:methanol =4:1) 8.64(1H, dd), 8.02(2H, d),      7.98(1H,dd), 7.53(1H, t), 7.26(1H, s), 7.04(2H, d), 4.08(2H, t),      3.58(2H, t),1.96-1.78(4H, m), 1.62-1.50(4H, m) 3600, 2300, 1650,      1600,1585, 1530, 1505, 1430,1380, 1295, 1255, 1180,1115, 1070, 1035,     8      890,45, 815, 765, 750 467(M.sup.+)431, 239 white powder       1(227)             ##STR214##       0.30(methylenechloride:methanol =4:1) 8.73(1H, dd), 8.01(2H, d),      7.96(1H,dd), 7.52(1H, t), 7.24(1H, s), 7.05(2H, d), 6.00-5.60(2H, m),      4.58(2H, d) 3500-2300, 1640, 1620,1600, 1580, 1520, 1500,1420, 1245      459(M.sup.+)339, 231 pale brown powder       1(228)             ##STR215##       0.38(chloroform:methanol =4:1) 8.58(1H, dd), 8.01(2H, d), 7.98(1H,dd),      7.53(1H, t), 7.32-7.16(5H, m),7.26(1H, s), 7.03(2H, d), 4.06(2H,t),      2.84(2H, t), 2.14-2.06(2H, m) 3600-2300, 1645, 1600,1580, 1525, 1505,      1425,1380, 1290, 1255, 1180,1060, 1030, 885, 835,810, 760, 740 467(M.sup.      +)413, 239 white powder       1(229)             ##STR216##       0.37(chloroform:methanol =4:1) 8.64(1H, dd), 8.04(2H, d), 7.98(1H,dd),      7.54(1H, t), 7.48-7.26(5H, m),7.27(1H, s), 7.12(2H, d), 6.80(1H,      d),6.44(1H, d), 4.83(2H, dd) 3600-2300, 1645, 1600,1580, 1520, 1500,      1425,1375, 1290, 1250, 1175,970, 885, 840, 810,765, 745 465(M.sup.+)345,      237 pale brown powder       1(230)             ##STR217##       0.38(chloroform:methanol =4:1) 8.57(1H, dd), 8.02(2H, d), 7.98(1H,dd),      7.54(1H, t), 7.30-7.15(5H, m),7.26(1H, s), 7.04(2H, d), 4.14-4.04(2H,      m), 2.76-2.68(2H, m), 1.90-1.80(4H, m) 3600-2300, 1645, 1600,1580, 1525,      1505, 1425,1380, 1290, 1255, 1180,1060, 1030, 885, 835,810, 760, 740      480(M.sup.+)423, 253 pale brown powder       1(231)             ##STR218##       0.31(chloroform:methanol =4:1) 8.74(1H, dd), 8.01(2H, d), 7.96(1H,dd),      7.52(1H, t), 7.24(1H, s), 7.03(2H, d), 5.95-5.72(1H, m), 5.10-4.90(2H,      m), 4.06(2H, t) 3100-2300, 1640, 1610,1595, 1575, 1515, 1495,1420, 1245      459(M.sup.+)231, 121 pale brown powder       1(232)             ##STR219##       0.43(chloroform:methanol =4:1) 8.60(1H, dd), 8.00(1H, dd), 7.97(2H,d),      7.54(1H, t), 7.38(2H, d), 7.28(1H, s), 2.73(2H, t), 1.80-1.60(2H,      m),1.42-1.22(8H, m), 0.89(3H, t) 3600-2300, 1645, 1620,1585, 1520, 1425,      1375,1290, 1065, 1030, 1015,890, 810, 765, 750 417(M.sup.+)363, 189      white powder       1(233)             ##STR220##       0.43(chloroform:methanol =4:1) 8.56(1H, dd), 8.00(1H, dd), 7.97(2H,d),      7.54(1H, t), 7.37(2H, d), 7.20(1H, s), 2.13(2H, t), 1.78-1.60(2H,      m),1.44-1.26(6H, m), 0.90(3H, t) 3600-2300, 1645, 1620,1585, 1520, 1425,      1375,1290, 1065, 1030, 1015,890, 765, 750 431(M.sup.+)377, 203 pale      brown powder       1(234)             ##STR221##       0.43(chloroform:methanol =4:1) 8.68(1H, dd), 7.99(1H, dd), 7.96(2H,d),      7.54(1H, t), 7.37(2H, d), 7.27(1H, s), 2.72(2H, t), 1.76-1.60(2H,      m),1.42-1.32(10H, m), 0.88(3H, t) 3600-2300, 1645, 1620,1585, 1525,      1425, 1375,1290, 1065, 1030, 1015,890, 765, 750 445(M.sup.+)391, 217      pale yellow powder       1(235)             ##STR222##       0.43(chloroform:methanol =4:1) 8.65(1H, dd), 8.00(1H, dd), 7.96(2H,d),      7.54(1H, t), 7.38(2H, d), 7.27(1H, s), 2.73(2H, t), 1.76-1.60(2H,      m),1.44-1.24(12H, m), 0.88(3H, t) 3600-2300, 1645, 1620,1585, 1525,      1425, 1375,1290, 1065, 1030, 1015,890, 810, 765, 750 459(M.sup.+)405,      231 pale yellow powder       1(236)             ##STR223##       0.29(methylenechloride:methanol =4:1) 8.73(1H, dd), 8.01(2H, d),      7.96(1H,dd), 7.51(1H, t), 7.23(1H, s), 7.13(1H, dd), 7.02(2H, d),      6.92(1H, dd),6.83(1H, brs) 3600-2300, 1640, 1610,1595, 1570, 1510,      1490,1415, 1250 487(M.sup.+)433, 259 pale brown powder       1(237)             ##STR224##       0.30(methylenechloride:methanol =4:1) 8.64(1H, dd), 7.92(2H, d),      7.88(1H,dd), 7.18(1H, s), 6.98(2H, d), 7.44(1H, t), 6.00-5.60(2H, m),      4.55(2H,brd) 3600-2300, 1640, 1610,1590, 1570, 1510, 1490,1420, 1245      445(M.sup.+)325, 231217, 189121 white powder       1(238)             ##STR225##       0.30(methylenechloride:methanol =4:1) 8.70(1H, dd), 8.00(2H, d),      7.95(1H,dd), 7.50(1H, t), 7.24(1H, s), 7.04(2H, d), 6.00-5.60(2H, m),      4.57(2H, d) 3600-2300, 1645, 1620,1595, 1575, 1520, 1495,1420, 1240      431(M.sup.+)311, 203121 pale yellow powder       1(239)             ##STR226##       0.45(chloroform: methanol =4:1) 8.53(1H, dd), 8.00(2H, d), 7.57(1H,dd),      7.24(1H, s), 7.05(2H, d), 5.98-5.64(3H, m), 5.06-4.90(2H, m), 4.60(2H,      d), 2.20-2.00(4H, m), 1.60-1.44(2H, m) 3600-2300, 1650, 1600,1510, 1480,      1435, 1390,1260, 1180, 900, 865 475(M.sup.+)355, 244 yellow powder      1(240)       ##STR227##       0.45(chloroform) 8.50(1H, dd), 8.00(2H, d), 7.58(1H,dd), 7.24(1H, s),      7.04(2H, d), 4.07(2H, t), 1.90-1.85(2H, m), 1.60-1.25(8H, m), 0.90(3H,      t) 3600-2300, 1655, 1600,1510, 1475, 1430, 1380,1260, 1180, 1035,      1015,895, 870 465(M.sup.+)229 yellow powder       1(241)             ##STR228##       0.51(chloroform:methanol =4:1) 8.52(1H, d), 7.96(2H, d), 7.70(1H,      d),7.21(5H, m), 7.16(1H, s), 6.97(2H, d),4.04(2H, t), 2.69(2H, t),      2.48(3H, s), 1.84(4H, m) 3600-2300, 1645, 1600,1530, 1505, 1250,      1180,1030, 890, 860, 840,760 441, 253 pale brown powder       1(242)             ##STR229##       0.32(chloroform:methanol =3:1) 8.58(1H, d), 8.00(2H, d), 7.73(1H,      d),7.20(1H, s), 7.03(2H, d), 5.60-6.00(2H, m), 4.56(2H, d), 2.52(3H,      s),2.10(2H, m) 2930, 2860, 1650, 1605,1600, 1535, 1510, 1460,1260, 1180,      1040, 900,770 473(M.sup.+)354, 231121, 11091 yellow powder  1(243)       ##STR230##       0.32(chloroform:methanol =3:1) 8.56(1H, d), 7.98(2H, d), 7.71(1H,      d),7.17(1H, s), 7.12(1H, d), 6.99(2H, d),6.91(1H, dd), 6.80(1H, d),      4.06(2H, m),2.92(2H, m), 2.50(3H, s), 1.88(4H, m) 2930, 1650, 1605,      1      1595,535, 1510, 1450, 1260,1180, 1035 501(M.sup. +)477, 259139, 12197      yellow brown powder       1(244)             ##STR231##       0.32(chloroform:methanol =3:1) 8.54(1H, d), 8.00(2H, d), 7.74(1H,      d),7.22(1H, s), 7.02(2H, d), 4.05(2H, t),2.54(3H, s) 2920, 2850, 1650,      1605,1595, 1530, 1505, 1465,1255, 1180, 1030, 840,760 475(M.sup.+)421,      233121 yellow brown powder       1(245)             ##STR232##       0.32(chloroform:methanol =3:1) 8.53(1H, d), 7.98(2H, d), 7.73(1H,      d),7.20(1H, s), 7.02(2H, d), 4.05(2H, t),2.51(3H, s) 2930, 2850, 1650,      1605,1595, 1535, 1510, 1470,1260, 1180, 1035, 895,765 461(M.sup.+)407,      219121 yellow brown powder       1(246)             ##STR233##       0.25(methylenechloride:methanol =5:1) 8.62(1H, d), 7.99(2H, d),      7.73(1H, d),7.18(1H, s), 7.01(2H, d),5.92-5.70(1H, m), 5.04-4.92(2H,      m),4.04(2H, t) 3460, 3070, 2930, 1650,1610, 1530, 1510, 1260 473(M.sup.+)2      31 white powder       1(247)             ##STR234##       0.28(chloroformmethanol =5:1) 8.42(1H, s), 7.85(2H, d), 7.60(1H,      s),7.06(1H, s), 6.91(2H, d), 5.90-5.50(3H, m), 5.00-4.82(2H, m),      4.47(2H, d) 3600-2300, 1650, 1600,1535, 1505, 1450, 1370,1330, 1310,      1250, 1180 471(M.sup.+)351, 257243, 229 yellow powder       1(248)             ##STR235##       0.30(methylenechloride:methanol =4:1) 8.60(1H, brs), 8.03(2H, d),      7.78(1H,brs), 7.26(1H, s), 7.08(2H, d),4.21(2H, t), 3.72(2H, t),      2.68(3H, s) 3600-2300, 1650, 1600, 1590, 1530, 1505, 1450,1255 446243,      241239, 121 pale yellow powder       1(249)             ##STR236##       0.30(methylenechloride:methanol =4:1) 8.73(1H, dd), 8.00(2H, d),      7.95(1H,dd), 7.51(1H, t), 7.24(1H, s), 7.03(2H, d), 4.05(2H, t) 3600-2300      , 1640, 1600,1580, 1520, 1500, 1420 445427, 255253, 121 pale brown      powder       1(250)             ##STR237##       0.48(methylenechloride:methanol =5:1) 8.52(1H, d), 8.00(2H, d),      7.75(1H, d),7.22(1H, s), 7.04(2H, d), 3.55(2H, t) 3600-3150, 3060,      2920,2850, 1650, 1605, 1530,1510, 1450, 1370, 1260 473267 yellow brown      powder       1(251)             ##STR238##       0.31(methylenechloride:methanol = 4:1) 8.57(1H, d), 7.98(2H, d),      7.72(1H, d),7.19(1H, s), 7.01(2H, d), 4.04(2H, t),3.54(2H, t) 3600-2300,      1650, 1600,1590, 1530, 1505, 1255 459.253, 181169, 121 pale brown powder       1(252)             ##STR239##       0.30(methylenechloride:methanol =5:1) 8.61(1H, d), 8.02(2H, d),      7.98(1H, d),7.54(1H, t), 7.05(2H, d), 4.08(2H, t),3.55(2H, t) 3450,      2920, 2850, 1650,1580, 1520, 1500, 1430,1290, 1250, 1180 459267 brown      powder       1(253)             ##STR240##       0.45(chloroform:methanol =4:1) 8.69(1H, d), 8.00(2H, d), 7.89(1H,      d),7.24(1H, s), 7.04(2H, d), 5.96-5.64(3H, m), 5.60-4.90(2H, m),      4.60(2H, d),2.10-2.00(4H, m), 1.60-1.42(2H, m) 3600-2300, 1650, 1600,1580      , 1500, 1460, 1410,1365, 1255, 1175, 1030,1000, 890, 870, 760 493(M.sup.+       )491,371 pale yellow powder       1(254)             ##STR241##       0.20(methylenechloride:methanol =5:1) 8.53(1H, dd), 7.94(2H, d),7.90(1H,       dd), 7.44(1H, t),7.28(1H, d), 7.26(1H, s),7.17(1H, s), 7.01(1H,      dd),6.96(2H, d), 3.99(2H, t),2.74(2H, t), 2.05(2H, m) 3450, 3070,      2920,1640, 1600, 1580,1520, 1500, 1470,1420, 1380, 1340,1290, 1250,      1      1180,030 307 brown powder       1(255)             ##STR242##       0.25(methylenechloride:methanol =5:1) 8.51(1H, d), 8.00(2H, dt),7.90.abo      ut.7.70(5H, m), 7.54˜7.35(3H, m), 7.21(1H, s),7.05(2H, dt),      4.38(2H, t) 3650˜2200,1640, 1610, 1510,1470, 1260, 1180,1020, 890,      850,820, 760, 600 275, 155,121 pale yellow powder       1(256)             ##STR243##       0.26(methylenechloride:methanol =5:1) 8.55(1H, d), 8.00(2H, dt),7.76.abo      ut.7.72(1H, m), 7.35(1H, d), 7.32(1H, d),7.06(1H, dd), 7.01(2H, dt),4.04(      2H, t) 3650˜2100,1650, 1610, 1540,1510, 1470, 1390,1260, 1180,      1130,1030, 940, 890,860, 840, 770 307, 121 yellow powder  1(257)       ##STR244##       0.23(methylenechloride:methanol =5:1) 8.76(1H, dd), 8.01(2H, d),7.96(1H,       dd), 7.80(4H, m),7.47(4H, m), 7.23(1H, s),7.06(2H, d), 4.38(2H,      t),3.11(2H, t) 3400, 3050, 1650,1600, 1580, 1500,1430, 1370, 1340,1250,      1160, 1060,1020, 880, 850,810, 750 275 yellow powder       1(258)             ##STR245##       0.19(methylenechloride:methanol =5:1)   287 pale brown powder  1(259)       ##STR246##       0.23(methylenechloride:methanol =5:1)   287 brown powder  1(260)       ##STR247##       0.28(methylenechloride:methanol =5:1)   273, 121 dark yellow powder

EXAMPLE 1(301)-1(302)

By the same procedure as example 1, using with p-pentylcinnamic acid and 8-amino-2-(5-tetrazolyl)-2,3-dihydro-1,4-dithianaphthalene hydrochloride or 5-amino-2-(5-tetrazolyl)-2,3-dihydro-1,4-dithianaphthalene hydrochloride, following compounds having the following physical data, shown in table [X] were given. ##STR248##

                                      TABLE X                                      __________________________________________________________________________            1                                                                            Rf value in TLC                                                           Example                                                                             (developing                                                               No.  solvent) NMR (δppm)  IR (γcm.sup.-1)                                                                  Mass Appearance                        __________________________________________________________________________     1(301)                                                                              0.33     776(1H,d), 7.55(2H,d), 7.44-7.10                                                                 3500-2300, 1660,                                                                       451(M.sup.+)                                                                        white                                  (chloroform:                                                                            (3H,m), 7.24(2H,d), 6.73(1H,d),                                                                  1620, 1610, 1565,                                                                      408, 372                                                                            powder                                 methanol =                                                                              5.15(1H,m), 3.66(2H,m), 2.64(2H,t),                                                              1510, 1180, 980                                                                        357, 355                                    3:1)     0.90(3H,t)                338, 201                               1(302)                                                                              0.23     7.72(1H,d), 7.51(2H,d), 7.22(2H,d),                                                              3500-2800, 1660,                                                                       201, white                                  (chloroform:                                                                            7.60-7.10(3H,m), 6.71(2H,d),                                                                     1620, 1610, 1560,                                                                      198  powder                                 methanol =                                                                              5.40-5.26(1H,m), 3.56-3.40(2H,m),                                                                1510                                                3:1)     2.68(2H,t), 1.64(2H,t), 0.90(3H,t)                               __________________________________________________________________________

EXAMPLE 1(401)

By the same procedure as example 1, using with p-heptyloxybenzodithioic acid and 8-amino-2-(5-tetrazolyl)-1,4-benzodioxane hydrochloride, following compound having following physical data was given. ##STR249##

TLC: Rf 0.14 (chloroform:methanol=17:3).

NMR: δ 7.87(2H, d), 7.77(1H, m), 6.90(4H, m), 5.74(1H, m), 4.58(2H, m), 3.98(2H, t), 1.78(2H, m), 1.30(8H, m), 0.88(3H, t).

IR: ν 3600-2400, 1600, 1495, 1450, 1255, 1170, 1090, 1005, 960, 830 cm⁻¹.

Mass: m/e 453(M⁺), 420, 354, 326, 235, 219, 137, 121.

Appearance: orange powder.

EXAMPLE 1(501)-1(526)

By the same procedure as example 1, using a corresponding carboxylic acid and a corresponding amine, following compounds having the following physical data, shown in table [XI] were given.

    TABLE XI         Rf value in TLC     Example  (developing No. Formula solvent) NMR      (δppm) IR (νcm.sup.-1) Mass Appearance               1(501)       ##STR250##       0.38(methylenechloride:methanol= 4:1) 8.00(2H, d), 7.98(1H, d),         s      7.59(1H,), 7.50(1H,dd), 7.33(1H,t),7.01(2H,d), 4.04(2H,t) 3430, 2920,      2840,1640, 1610, 1530,1500, 1420, 1250 405(m.sup.+),205 whitepowder      1(502)       ##STR251##       0.38(methylenechloride:methanol=       5:1) 8.00(2H,d), 7.97(1H,dd), 7.59(1H,s), 7.50(1H,dd), 7.32(1H,t),      4.04(2H,t), 7.01(2H,d) 3430, 2920, 2840,1640, 1610, 1530,1500, 1420,      1250 433(m.sup.+),233 whitepowder       1(503)      ##STR252##       0.38(methylenechloride:methanol=       4:1) 8.00(2H,d), 8.00(1H,dd), 7.58(1H,s), 7.50(1H,dd), 7.33(1H,t),      7.01(2H,d), 4.04(2H,t) 3430, 2920, 2840,1640, 1610, 1530,1500, 1420,      1250 419(m.sup.+),219 yellowpowder       1(504)      ##STR253##       0.35(methylenechloride:methanol=       5:1) 7.99(2H,d), 7.97(1H,dd), 7.58(1H,s), 7.49(1H,dd), 7.33(1H,t),      7.00(2H,d), 4.04(2H,t) 3430, 2920, 2840,1640, 1610, 1530,1500, 1420,      1250 447(m.sup.+),247 brownpowder       1(505)      ##STR254##       0.38(methylenechloride:methanol=       4:1) 7.94(2H,dd), 7.40(1H,d), 7.09(1H,dd), 6.97(2H,dd), 6.96(1H,t),      6.21(1H,dd), 4.02(2H,t),3.88(1H,dd), 3.50(1H,dd) 3720, 3020, 2920,2850,      2730, 1640,1610, 1520, 1500,1440, 1310, 1250 407(m.sup. +),205 whitepowde      r       1(506)      ##STR255##       0.38(methylenechloride:methanol=       5:1) 7.94(2H,dd), 7.34(1H,d), 7.11(1H,d), 6.98(2H,dd), 6.97(1H,t),6.22(1      H,dd), 4.03(2H,t), 6.89(1H,dd), 6.50(1H,dd) 3720, 3020, 2920,2850, 2730,      1640,1610, 1520, 1500,1440, 1310, 1250 421(m.sup.+),219 whitepowder      1(507)       ##STR256##       0.38(methylenechloride:methanol=  4:1) 7.94(2H,dd), 7.41(1H,d),      7.09(1H,dd), 6.98(2H,dd), 6.97(1H,t), 6.21(1H,dd), 4.02(2H,t),3.88(1H,dd)      , 3.51(1H,dd) 3720, 3020, 2920,2850, 2730, 1640,1610, 1520, 1500,1440,      1310, 1250 435(m.sup.+),233 whitepowder       1(508)      ##STR257##       0.39(methylenechloride:methanol=       4:1) 7.95(2H,dd), 7.41(1H,d), 7.10(1H,dd), 6.97(2H,dd), 6.99(1H,t),      6.22(1H,dd), 4.04(2H,t),3.89(1H,dd), 3.51(1H,dd) 3720, 3020, 2920,2850,      2730, 1640,1610, 1520, 1500,1440, 1310, 1250 449(m.sup.+),247 whitepowder       1(509)      ##STR258##       0.30(methylenechloride:methanol=       5:1) 7.97(2H,dd), 7.88(1H,d), 7.48(1H,d), 6.97˜7.14(7H,m),6.97(2H,      d) 3700˜2100, 1650,1610, 1500, 1420,1390, 1350, 1300,1260, 1220,      1180,1070, 1020, 850, 740 453(m.sup.+,253,121 whitepowder  1(510)       ##STR259##       0.34(methylenechloride:methanol=       5:1) 7.97(2H,d), 7.88(1H,d), 7.47(1H,dd), 7.36˜7.23(2H,m),      7.00(2H,d), 5.98˜5.64(3H,m), 5.10˜4.92(2H,m), 4.55(2H,d)      3600˜2100, 1640,1600, 1500, 1430,1390, 1350, 1300,1260, 1190,      1      1060,000, 920, 840, 750 429(m.sup.+), 229,201,121 whitepowder  1(511)       ##STR260##       0.40(methylenechloride:methanol= 5:1) 8.00(2H,dt), 7.95(1H,dd),      7.49(1H,dd)7.31(1H,t), 7.29(1H,s), 7.00(2H,dt)4.05(2H,t) 3500˜2100,       1640, 1610,1500, 1420, 1290, 1260,1200, 1110, 1050, 840,740 439(m.sup.+)      ,239, 121 whitepowder         1(512)      ##STR261##       0.32(chloroform:methanol=       5:1) 7.87(2H,d), 7.33(2H,m), 6.92(2H,d),6.83(1H,t), 6.66(1H,dd),      3.98(2H,t),1.78(2H,m), 1.30(8H,m), 0.88(3H,m) 3650˜2400, 1640,      1605,1500,1445, 1250 325,219 palebrownpowder       1(513)      ##STR262##       0.09(chloroform:methanol=       9:1) 7.85(2H,d), 7.30(2H,m), 6.88(2H,d),6.80(10H,t), 6.62(1H,d),      3.96(2H,d)1.77(2H,m), 1.34,(6H,m), 0.88(3H,t) 3600-2500, 1630, 1600,1495,       1440, 1240. 205121 palebrownpowder       1(514)      ##STR263##       0.40(methylenechloride:methanol=       5:1) 8.57(1H,s), 8.07(1H,d), 8.02(2H,d),7.93(1H,d), 7.82(1H,d),      7.75(1H,d)7.54(1H,t), 7.30-7.18(5H,m),6.98(3H,d), 4.04(2H,t) 3400, 2910,      1615, 1605,1560, 1480, 1380, 1300,1280, 1250, 1170, 1060,830, 750, 690      463(m.sup.+),420,253 yellowpowder       1(515)      ##STR264##       0.17(methylenechloride:ethyl acetate= 2:1) 8.84(1H,dd), 8.40(1H,d),      8.28(1H,d)7.96(2H,d), 7.64˜7.56(2H,m), 6.99(2H,d), 5.80-5.56(3H,m),       4.98-4.88(2H,m),4.50(2H,d), 2.12-1.94(4H,m), 1.52-1.36(2H,m) 3600-2300,      1635, 1600,1530, 1510, 1250, 1175,840, 760 548,440(m.sup.+),412, 332,320 y      ellowpowder       1(516)      ##STR265##       0.18(methylenechloride:ethyl acetate= 2:1) 8.93(1H,dd), 8.48(1H,d),      8.38(1H,d),8.04(2H,d), 7.76-7.64(2H,m), 7.32-7.16(5H,m), 7.04(2H,d),      4.09(2H,t), 2.72(2H,t), 1.94-1.80(14Hm) 3600-2300, 1635, 1605,1530,      1505, 1250, 1170,835, 760  paleyellowpowder       1(517)      ##STR266##       0.47(methylenechloride:methanol=       5:1) 8.03(1H,dd), 7.93(2H,d), 7.36-7.14(5H,m), 7.04(1H,t), 6.96(2H,d),      6.83(1H,dd), 5.45(1H,dd), 4.60(1H,dt),4.15(1H,dt) 3400-2300, 1645,      1610,1510, 1480, 1450, 1260,1060 485(m.sup.+),442, 439,411, 377,359      p      whiteowder       1(518)      ##STR267##       0.49(methylenechloride:methanol=       5:1) 8.01(1H,dd), 7.93(2H,d), 7.03(1H,t),6.97(2H,d), 6.82(1H,dd),      5.96-5.60(2H,m), 5.45(1H,d), 5.07-6.90(2H,m),4.62(1H,dt), 4.15(1H,dt),      4.53(2H,d) 3260, 3200-2300, 1645,1610, 1500, 1475, 1450,1255. 461,      405,353, 341 whitepowder       1(519)      ##STR268##       0.18(methylenechloride:methanol=       2:1) 8.95(1H,dd), 8.49(1H,d), 8.38(1H,d),8.06(2H,d), 7.78-7.66(2H,m),      7.06(2H,d), 4.10(2H,t), 3.58(2H,t), 2.00-1.78(4H,m), 1.70-1.50(4H,m)      3600-2300, 1635, 1600,1530, 1510, 1255, 1175,840, 765  yellowpowder      1(520)       ##STR269##       0.20(chloroform:methanol=       4:1) 8.00(2H,dd), 7.93(2H,d), 7.04(1H,t),6.95(2H,d), 6.83(1H,dd),      5.81(1H,m),5.45(1H,dd), 5.00(2H,m), 4.60(1H,m),4.18(1H,m), 4.00(2H,t),      2.74(2H,m),2.07(2H,m), 1.80(2H,m), 1.42(6H,m) 3200, 2930, 2860, 1605,1565      , 1540, 1505, 1470,1450, 1250, 1060 463(m.sup.+),407, 231,121, 93      yellowpowder       1(521)      ##STR270##       0.55(methylenechloride:methanol =                                       (       5:1) 7.88(2H,d), 7.5481H,m), 7.34-7.125H,m), 7.00-6.86(4H,m), 5.73(1H,dd      ),4.02(2H,t) 3300-2200, 1610, 1530,1510, 1460, 1260 468(m.sup.+),441,      426,413, 395,253 whitepowder       1(522)      ##STR271##       0.42(methylenechloride:methanol=       5:1) 7.88(2H,d), 7.50(1H,m), 7.00-6.88(4H,m), 5.92-5.66(2H,m), 5.06-4.90(      2H,m), 4.02(2H,t) 3400-2300, 1610, 1570,1530, 1505, 1460, 1260 447(m.sup.      +),253, 132 whitepowder       1(523)      ##STR272##       0.25(methylenechloride:methanol= 5:1) 7.91(2H,d), 7.35-7.19(6H,m),      6.95(2H,d), 6.94(1H,t), 6.78(1H,dd),4.03(2H,t) 3400, 3100-2300, 1660,1610      , 1580, 1530, 1500,1450, 1250 253, 225,121 palebrownpowder  1(524)       ##STR273##       0.25(methylenechloride:methanol=       5:1) 8.15(1H,d), 7.78(1H,d), 7.65-7.20(8H,m), 6.90(1H,d), 2.66(2H,t),0.9      2(3H,t) 3300, 1630, 1530, 1200,740 401(m.sup.+),373, 372358, 344      palebrownpowder       1(525)      ##STR274##       0.27(chloroform: methanol=       3:1) 7.68(1H,d), 7.44(2H,d), 7.40(1H,s),7.25(1H,d), 7.18(2H,d),      6.90(1H,t),6.73(1H,d), 6.65(1H,d), 2.62(2H,t),1.62(2H,m), 1.20-1.45(4H,m)      , 0.89(3H,t), 3250, 2930, 2850, 1660,1620, 1600m 1525, 1445,1340, 1255,      1180, 1070,980, 825, 765, 710 405, 349336, 325,306, 210,131, 115palebrownp      owder       1(526)      ##STR275##       0.40(methylenechloride:methanol= 5:1) 8.31(1H, s), 7.94(2H, d),7.86(1H,      d), 7.72(1H, d),7.68(1H, d), 7.57(1H, d),7.41(1H, t), 6.90(2H, d), 3.96(2      H, t), 3.55(2H, t) 3400, 2920, 1615,1605, 1480, 1300,1250, 1170, 830750      239 yellowpowder

EXAMPLE 2 Synthesis of 8-(3-methoxy-4-pentyloxycinnamoyl)amino-2-(5-tetrazolyl)-1,4-benzodioxane ##STR276##

Sodium azide (490 mg) and pyridinium chloride (870 mg) were added to a solution of 8-(3-methoxy-4-pentyloxycinnamoyl)amino-1,4-benzodioxane (560 mg; synthesized in reference example 2) in dry dimethylformamide (3 ml). In an atmosphere of argon, the solution was stirred for 1.5 hrs at 100° C. The reaction solution cooled to room temperature was poured into 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with water and a saturated aqueous solution of sodium chloride, dried, and then concentrated under reduced pressure. The residue was recrystallized from ethyl acetate to give the title compound (390 mg) having the following physical data:

TLC: Rf 0.10 (chloroform:methanol=5:1).

NMR: δ 7.69(1H, d), 7.68(1H, s), 7.05-7.25(2H, m), 6.80-7.00(2H, m), 6.74(1H, m), 6.65(1H, d), 5.73(1H, m), 4.69(1H, dd), 4.51(1H, dd), 4.05(2H, t), 3.92(3H, s), 1.87(2H, m), 1.30-1.55(4H, m), 0.94(3H, t).

IR: ν 2940, 2850, 1655, 1600, 1540, 1505, 1450, 1260 cm⁻¹.

Mass: m/e 465(M⁺), 247, 177, 145.

EXAMPLE 2(1)-2(46)

By the same procedures as reference example 1, 2 and example 1, using a corresponding carboxylic acid and 3-aminopyrocatechol, following compounds having the following physical data, shown in table [XII] were given. ##STR277##

    TABLE XII        Substituent R Rf value in TLC     Example in the general (developing      No. formula (Io) solvent) NMR (δppm) IR (νcm.sup.-1) Mass      Appearance               2(1)       0.28(methylenechloride:methanol =5:1) 7.72(1H,d), 7.66(1H,m), 7.46(2H,d)      ,7.18(2H,d), 6.88(1H,t), 6.74(1H,d),6.72(1H,dd), 5.67(1H,dd), 4.65(1H,dd)      ,2.62(2H,t), 1.62(2H,m), 1.20-1.45(4H,m), 0.88(3H,t) 3250, 2930,      2860,1660, 1610, 1540,1260, 1200, 1100,965, 775, 715 419(M.sup.+)219,    1      20131 whitepowder       2(2)      ##STR278##       0.3(methylenechloride:methanol =4:1) (DMSOd.sub.6)9.24(1H,s), 7.78(1H,d)      , 7.56(1H,d), 7.15-7.30(2H,m), 7.00(1H,d), 6.94(1H,d), 6.87(1H,t),      6.68(1H,dd), 6.00(1H,dd), 4.68(1H,dd), 4.49(1H,dd), 3.82(3H,s), 3.80(3H,s      ) 1660, 1600, 1540,1510, 1480, 1450 409(M.sup. +)366, 353315, 296258,    2      23319, 191 paleyellowpowder       2(3)      ##STR279##       0.3(methylenechloride:methanol =5:1) 8.02(1H,s), 7.80(1H,d), 7.35-7.50(2      H,m), 7.24(1H,d), 7.20-7.35(2H,m), 6.83(1H,t), 6.72(1H,d), 6.62(1H,d),      5.73(1H,m), 4.72(1H,dd), 4.56(1H,dd) (liquid film)1650,1610, 1540,      1480,1450 447(M.sup.+)419, 404391, 353334, 229219 whitepowder  2(4)       ##STR280##       0.3(methylenechloride:methanol =5:1) 8.46(1H,s), 7.8-8.1(4H,m),      7.5-7.7(3H,m), 6.94(1H,t), 6.78(1H,dd),5.78(1H,dd), 4.52-4.74(2H,m)      1620, 1605, 1540,1500, 1460, 1430 373(M.sup.+)331, 296223, 155 whitepowde      r       2(5)      ##STR281##       0.3(methylenechloride:methanol =5:1) (CDCl.sub.3)7.85(1H,d), 7.4-7.55(2H      ,m), 7.34(1H,s), 7.15-7.30(2H,m), 6.7-6.9(3H,m),6.56(1H,d), 5.78(1H,m),      4.98(1H,dd),4.50(1H,dd), 2.68(2H,q), 1.25(3H,t) 1650, 1605, 1530,1475,      1450 377(M.sup.+)219, 159129 paleyellowpowder       2(6)      ##STR282##       0.3(methylenechloride:methanol =5:1) 7.64(1H,d), 7.40-7.55(2H,m),      7.10-7.25(2H,m), 6.98(1H,dd), 6.86(1H,t),6.76(1H,dd), 6.57(1H,d),      5.78(1H,m),4.90(1H,d), 4.52(1H,d) 1660, 1605, 1530,1480, 1445 391(M.sup.+      )219, 173131, 115 paleyellowpowder       2(7)      ##STR283##       0.3(methylenechloride:methanol =5:1) 7.82(1H,d), 7.40-7.55(2H,m),      7.1-7.25(2H,m), 7.11(1H,d), 6.85(1H,t),6.74(1H,dd), 6.59(1H,d), 5.76(1H,m      ),4.81(1H,d), 4.54(1H,d) 1660, 1605, 1535,1480, 1450 405(M.sup.+)219,    1      18731 paleyellowpowder       2(8)      ##STR284##       0.3(methylenechloride:methanol =5:1) 7.76(1H,d), 7.52(1H,d), 7.40(1H,s),7      .32(1H,d), 7.20(1H,d), 6.89(1H,t),6.73(1H,dd), 6.65(1H,d), 5.72(1H,dd),4.      64(1H,dd), 4.54(1H,dd) 1650, 1605, 1540,1470, 1450 389(M.sup.+)276,      219171, 143128, 115 palebrownpowder       2(9)      ##STR285##       0.45(methylenechloride:methanol =5:1) (CDCl.sub.3)7.23(5H,m), 6.77(3H,m)      , 5.75(1H,t),4.93(1H,dd), 4.46(1H,dd), 3.76(2H,s),2.61(2H,t), 161(2H,m),      1.33(4H,m),0.88(3H,t) 3600-2300, 1660,1620, 1605, 1550,1465, 1270,      1205,1090, 780 407(M.sup.+)219, 188161 yellowpowder       2(10)      ##STR286##       0.20(chloroform:methanol =4:1) (CDCl.sub.3)8.0(1H,s), 7.80(2H,d),      6.7-7.1(5H,m),5.75(1H,m), 4.85(1H,dd), 4.50(1H,dd), 4.00(2H,t) 2950,      1640, 1610,1540, 1510, 1460,1260, 1180, 1100,845, 780 409(M.sup.+)366,      259191, 121 whitepowder       2(11)      ##STR287##       0.20 (chloroform:methanol =4:1) 7.86(1H,s), 7.76(1H,d), 7.39(2H,d),7.17(      1H,d), 6.70(2H,d), 6.76(1H,t),6.66(1H,dd), 6.48(1H,d), 5.69(1H,dd),4.66(1      H,dd), 4.51(1H,dd), 3.92(2H,t) 2950, 1655, 1600,1535, 1505, 1450,1250,      1165, 1100,960, 820, 770 435(M.sup.+)392, 259217, 147119 paleyellowpowder       2(12)      ##STR288##       0.55(methylenechloride:methanol =4:1) 8.09(1H,d), 7.77(2H,m), 7.23(3H,m)      ,6.92(1H,t), 6.71(2H,m), 5.73(1H,dd),4.69(1H,dd), 4.49(1H,dd), 2.78(2H,t)      ,1.58(2H,m), 1.34(4H,m), 0.88(3H,t) 3600-2200, 1660,1620, 1605, 1555,1450      , 1270, 1200,1105, 970, 780,760 419(M.sup.+)219, 201 whitepowder  2(13)       ##STR289##       0.71(methylenechloride:methanol =4:1) 7.72(1H,d), 7.76(1H,dd), 7.28(4H,m      ),6.90(1H,t), 6.76(1H,d), 6.73(1H,dd),5.72(1H,dd), 4.67(1H,dd), 4.49(1H,d      d),2.61(2H,t), 1.62(2H,m), 1.26(10H,m),0.87(3H,t) 3600-2300, 1660,1650,      1555, 1460,1260, 1190, 1100,980, 960, 775 461(M.sup.+) 243, 219 whitepowd      er       2(14)      ##STR290##       0.30(methylenechloride:methanol =4:1) 7.76(1H,d), 7.52(1H,d), 7.47(2H,d)      ,7.19(2H,d), 6.90(1H,t), 6.75(1H,dd),6.67(1H,d), 5.72(1H,dd), 4.70-4.50(2      H,m) 3300-2300, 1670,1625, 1555, 1470 433(M.sup.+)219, 215 whitecrystal      2(15)       ##STR291##       0.30(methylenechloride:methanol =4:1) 7.75(1H,d), 7.52(1H,d), 7.46(2H,d)      ,7.17(2H,d), 6.88(1H,t), 6.75(1H,dd),6.66(1H,d), 5.70(1H,dd), 4.80-4.45(2      H,m) 3300-2300, 1675,1635, 1620, 1560,1465, 1270 475(M.sup.+)257, 219      whitecrystal       2(16)      ##STR292##       0.30(methylenechloride:methanol =5:1) 7.76(1H,d), 7.53(1H,d), 7.46(2H,d)      ,7.18(2H,d), 6.89(1H,t), 6.74(1H,dd),6.68(1H,d), 4.72(1H,dd) 3500-2300,      1665,1630, 1615, 1550,1460, 1260 461(M.sup.+)243, 219 whitecrystal      2(17)       ##STR293##       0.52(methylenechloride:methanol =17:3) 7.72(3H,m), 7.33(2H,m), 6.88(1H,t      ),6.73(1H,dd), 5.60(1H,dd), 4.51(2H,m),2.65(2H,t), 1.62(2H,m), 1.28(10H,m      ),0.87(3H,t) 3650-2700, 2920,2840, 1650, 1605,1520, 1450, 1260,1080,      900, 870 218, 217 paleyellowpowder       2(18)      ##STR294##       0.40(methylenechloride:methanol =17:3) 7.98(1H,m), 7.50(1H,m), 7.39(1H,m      ),7.30(3H,m), 6.94(1H,t), 6.79(1H,dd),5.74(1H,m), 4.62(2H,m), 2.83(2H,t),1      .65(2H,m), 1.28(4H,m), 0.86(3H,m) 3600-2300, 1660,1640, 1610, 1520,1480,      1450, 1260,1100, 775 393(M.sup.+)219, 175 yellowpowder       2(19)      ##STR295##       0.10(chloroform:methanol =5:1) (CDCl.sub.3)7.92(1H,s), 7.40-7.60(2H,m),      7.10-7.25(1H,m), 6.70-7.00(4H,m), 5.77(1H,t), 4.97(1H,dd), 4.50(1H,dd),      4.07(2H,t), 3.94(3H,s), 1.88(2H,m), 1.30-1.60(4H,m), 0.94(3H,t) 2930,      1630, 1600,1580, 1540, 1505, 1460, 1340, 1265 439, 341221, 151123      whitepowder       2(20)      ##STR296##       0.10(chloroform:methanol =5:1) (CDCl.sub.3)7.98(1H,s), 7.30-7.55(3H,m),      7.05-7.20(1H,m), 6.70-7.00(3H,m), 5.77(1H,t), 4.95(1H,dd), 4.50(1H,dd),      4.02(2H,t), 1.82(2H,m),1.25-1.60(4H,m), 0.94(3H,t) 2950, 1635, 1605,1580,       1540, 1450,1335, 1260, 1230,1085, 780 409(M.sup.+)259, 191138, 12193      whitepowder       2(21)      ##STR297##       0.10(chloroform:methanol =5:1) (CDCl.sub.3)7.70-7.90(2H,m), 6.50-7.50(9H      ,m),5.74(1H,m), 4.80(1H,m), 4.52(1H,m),3.93(2H,t), 1.78(2H,m), 1.20-1.60(      4H,m), 0.93(3H,t) 2950, 2860, 1660,1600, 1540, 1450,1260, 1195, 1100,1050      , 970, 780 435(M.sup.+)219, 217191, 175147 whitepowder       2(22)      ##STR298##       0.10 (chloroform:methanol =5:1) (CDCl.sub.3) 10.03(1H,s), 8.35(1H,dd),      7.50(1H,m), 7.25(1H,s), 7.15(1H,m), 7.03(1H,d), 6.70-6.95(3H,m),      5.75(1H,t), 4.98(1H,dd), 4.50(1H,dd), 4.20(2H,t), 1.90(2H,m),1.20-1.60(4H      ,m), 0.90(3H,t) 3320, 2950, 2860,1640, 1610, 1545,1460, 1300, 1235,1085,      775, 760 409(M.sup.+)367, 191149, 121 whitepowder       2(23)      ##STR299##       0.10(chloroform:methanol =5:1) (CDCl.sub.3) 8.11(1H,d), 7.40-7.60(2H,m),       7.20-7.40(1H,m), 7.02(1H,d), 6.65-6.95(5H,m),5.76(1H,t), 4.85(1H,m),      4.52(1H,m), 4.00(2H,t), 1.85(2H,m), 1.20-1.60(4H,m),0.92(3H,t) 2950,      2860, 1655,1610, 1540, 1480,1450 435(M.sup.+)407, 348341, 219217, 147      whitepowder       2(24)      ##STR300##       0.30(chloroform:methanol =5:1) 7.77(1H,d), 7.65(1H,d), 7.50(2H,d),7.22(2      H,d), 6.93(1H,t), 6.76(1H,dd),6.73(1H,d), 5.74(1H,dd), 4.69(1H,dd),4.54(1      H,dd) 3300-2500, 1670,1630, 1620, 1555,1460, 1260 489(M.sup.+ )271, 219      whitecrystal       2(25)      ##STR301##       0.37(methylenechloride:methanol =17:3) 7.86(1H,s), 7.68(1H,dd),      7.42(4H,m),6.92(1H,t), 6.77(1H,dd), 5.75(1H,dd),4.61(2H,m), 2.98(2H,t),      1.67(2H,m),1.38(4H,m), 0.89(3H,t) 3600-2300, 1640,1610, 1540, 1455,1340,      1270, 1260,1090, 770 425(M.sup.+)207 whitepowder       2(26)      ##STR302##       0.47(methylenechloride:methanol =17:3) 7.81(1H,d), 7.26(4H,m), 6.91(1H,t      ),6.77(1H,dd), 5.75(1H,dd), 4.69(1H,dd),4.58(1H,dd), 2.92(2H,t),      1.60(2H,m),1.32(4H,m), 0.86(3H,t) 3600-2300, 1630,1610, 1540, 1460,1320,      1260, 1090,780, 740 425(M.sup.+)219, 207 yellowpowder       2(27)      ##STR303##       0.14(chloroform:methanol =4:1) (CDCl.sub.3)7.92(1H,s), 7.85(2H,d),      7.30(2H,d), 6.70-7.00(3H,m), 5.76(1H,t), 4.95(1H,dd), 4.50(1H,dd),      2.70(2H,t), 1.50-1.80(2H,m),1.20-1.50(2H,m), 0.94(3H,t) 2930, 2850,      1      1610,535, 1460, 1330,1280, 1260, 1090 379(M.sup.+)229, 161118, 91      whitepowder       2(28)      ##STR304##       0.14(chloroform:methanol =4:1) (CDCl.sub.3)8.12(1H,s), 7.82(2H,d),      7.26(2H,d), 6.70-7.10(3H,m), 5.72(1H,t), 4.83(1H,dd), 4.47(1H,dd),      2.66(2H,t), 1.62(2H,m), 1.10-1.45(6H,m), 0.88(3H,t) 2930, 2850, 1640,1610      , 1545, 1455,1330, 1280, 1260,1090, 770 407(M.sup.+)257, 189118, 91      p      whiteowder       2(29)      ##STR305##       0.14(chloroform:methanol =4:1) (CDCl.sub.3)8.04(1H,s), 7.83(2H,d),      7.28(2H,d), 6.70-7.10(3H,m), 5.74(1H,t), 4.85(1H,dd), 4.48(1H,dd),      2.67(2H,t), 1.63(2H,m), 1.10-1.45(8H,m), 0.88(3H,t) 2930, 2850, 1640,1620      , 1550, 1460,1340, 1280, 1270,1100 421(M.sup.+)271, 203131, 11891      whitepowder       2(30)      ##STR306##        0.14(chloroform:methanol =4:1) (CDCl.sub.3)8.07(1H,s), 7.83(2H,d),      7.27(2H,d), 6.70-7.10(3H,m), 5.74(1H,t), 4.85(1H,dd), 4.48(1H,dd),      2.67(2H,t), 1.63(2H,m), 1.10-1.45(10H,m), 0.88(3H,t) 2930, 2850,      1640,1620, 1550, 1460,1340, 1280, 1270,1100 435(M.sup.+)285, 217131,      11891 paleyellowpowder       2(31)      ##STR307##       0.14(chloroform:methanol =4:1) (CDCl.sub.3) 7.81(1H,d), 7.50(1H,s),     (      7.472H,d), 6.70-7.10(5H,m), 6.48(1H,d),5.76(1H,m), 4.86(1H,dd), 4.70(2H,m      ),4.53(1H,dd), 2.22(2H,t), 1.60(1H,s), 1.50(2H,m), 1.15-1.45(4H,m),      0.87(3H,t) 2930, 2860, 1660,1600, 1540, 1505,1450, 1260, 1170,1100,      1000, 960,825, 775 473(M.sup.+)255, 219147, 119 whitepowder  2(32)       ##STR308##       0.46(methylenechloride:methanol =17:3) 7.69(1H,d), 7.44(1H,m), 7.28(3H,m      ), 6.86(1H,t), 6.71(1H,dd), 6.68(1H,d),5.69(1H,t), 4.60(2H,m), 2.91(2H,t)      ,1.64(2H,m), 1.36(4H,m), 0.88(3H,t) 3600-2200, 1650,1605, 1540, 1450,1260      , 1190, 1090,960, 780, 770 451(M.sup.+)233, 219 whitepowder  2(33)       ##STR309##       0.36(methylenechloride:methanol =17:3) 8.29(1H,d), 7.51(2H,m), 7.28(3H,m      ),6.86(1H,t), 6.71(1H,dd), 6.62(1H,d),5.71(1H,dd), 4.60(2H,m), 2.88(2H,t)      ,1.62(2H,m), 1.36(4H,m), 0.88(3H,t) 3600-2300, 1660,1620, 1555, 1450,1265      , 1200, 1105,970, 780, 760 451(M.sup.+)348 paleyellowpowder  2(34)       ##STR310##       0.49(methylenechloride:methanol =17:3) 7.74(1H,d), 7.48(3H,m), 7.24(3H,m      ),6.87(1H,t), 6.72(1H,dd), 6.67(1H,d),5.70(1H,m), 4.59(2H,m), 1.26(6H,d) 3      600-2300, 1640,1610, 1540, 1450,1255, 1200, 1090,960, 820 391(M.sup.+)219      , 173 whitepowder       2(35)      ##STR311##       0.62(methylenechloride:methanol =17:3) 7.74(1H,d), 7.43(3H,m), 7.22(2H,d      ),6.85(1H,t), 6.70(1H,dd), 6.66(1H,d),5.68(1H,m), 5.59(2H,m), 2.48(2H,d),1      .86(1H,m), 0.90(6H,d) 3600-2300, 1655,1610, 1540, 1455,1260, 1100,      965,835, 770, 710 405(M.sup.+)219, 187 whitepowder       2(36)      ##STR312##       0.10(chloroform:methanol =4:1) (CDCl.sub.3)8.10(1H,s), 7.85(2H,d),      6.60-7.10(5H,m), 5.50-6.00(3H,m), 4.80(1H,dd),4.30-4.70(3H,m), 2.10(2H,m)      ,1.10-1.60(6H,m), 0.89(3H,t) 2930, 2860, 2730,1630, 1600, 1540,1495,      1450, 1310,1250, 1170, 1090,990, 835, 765 559,449(M.sup.+)329, 121      palebrownpowder       2(37)      ##STR313##       0.10(chloroform:methanol =4:1) (CDCl.sub.3)7.80(1H,d), 7.66(1H,s),      7.42(2H,d), 7.08(1H,d), 6.65-7.10(4H,m), 6.48(1H,d), 5.55-6.00(3H,m),      4.75(1H,dd), 4.40-4.65(3H,m),2.08(2H,m), 1.10-1.60(6H,m), 0.88(3H,t)      2930, 2860, 1680,1600, 1540, 1510,1460, 1265, 1180,1100, 970, 830,780      585,475(M.sup.+)329, 147 whitepowder       2(38)      ##STR314##       0.57(chloroform:methanol =4:1) 7.74(1H,d), 7.59(1H,d), 7.47(2H,d),7.19(1      H,d), 6.90(1H,t), 6.73(1H,dd),6.68(1H,d), 5.71(1H,dd), 4.66(1H,dd),4.52(1      H,dd), 2.63(2H,m), 2.40(1H,m),1.52(2H,m), 0.94(6H,d) 3600-2300, 1660,1610      , 1540, 1460,1265, 1200, 1100,965 419(M.sup.+)219, 201 whitepowder      2(39)       ##STR315##       0.42(methylenechloride:methanol =17:3) 7.30(1H,m), 7.03(1H,m), 6.84(1H,t      ),6.72(1H,d), 6.03(1H,d), 5.70(1H,m),4.60(1H,m), 2.23(2H,m), 1.36(22H,m),0      .88(3H,t) 3600-2200, 2900, 2835,1675, 1660, 1610, 1530,1460, 1440, 1260,      1205,1100, 1040, 970, 910,860, 770, 710 455(M.sup.+)237, 219 whitepowder       2(40)      ##STR316##       0.10(chloroform:methanol =4:1) (CDCl.sub.3  + DMSOd.sub.6)7.52(2H,d),      6.91(2H,d), 6.91(1H,t),6.70(1H,d), 6.68(1H,d), 5.70(1H,dd),4.78(1H,dd),      4.40(1H,dd), 3.96(2H,t),1.83(2H,m) 2970, 2680, 1660,1600, 1540, 1510,1455      , 1260, 1170,1100, 970, 825,770, 710, 560, 515 407(M.sup.+)219, 189147,      11991 whitepowder       2(41)      ##STR317##       0.10(chloroform:methanol =4:1) (CDCl.sub.3 + DMSOd.sub.6)8.68(1H,s),      7.86(1H,d), 7.72(1H,d), 7.52(2H,d), 6.91(1H,t), 6.90(2H,d), 6.71(1H,d),      6.67(1H,d), 5.70(1H,dd), 4.78(1H,dd),4.40(1H,dd), 4.00(2H,t) 2970, 2870,      1660,1600, 1540, 1510,1460, 1260, 1190,1175, 1100, 970,830, 770, 715,      565 421(M.sup.+)219, 203147, 11991, 69 whitepowder       2(42)      ##STR318##       0.10(chloroform:methanol =4:1) (CDCl.sub.3 + DMSOd.sub.6)8.62(1H,s),      7.81(1H,d), 7.72(1H,d), 7.50(2H,d), 6.90(1H,t), 6.88(2H,d), 6.70(1H,d),      6.65(1H,d), 5.68(1H,dd), 4.76(1H,dd),4.40(1H,dd), 3.98(2H,t) 2920, 2850,      1660,1600, 1540, 1510,1460, 1260, 1170,1100, 970, 910, 825,770, 715,      565, 520 477(M.sup.+)259, 219189, 147119 paleyellowpowder  2(43)       ##STR319##       0.30(methylenechloride:methanol =5:1) 7.52(1H,s), 7.30(2H,d), 7.20(2H,d)      ,7.15(1H,dd), 6.89(1H,t), 6.76(1H,dd),5.78(1H,dd), 4.80(1H,dd), 4.52(1H,d      d) 3250, 3200-2300,1640, 1600, 1550,1530, 1490, 1470,1110, 780 433(M.sup.      +)286, 281215 whitepowder       2(44)      ##STR320##       0.35(chloroform:methanol =4:1) 7.88(2H,d), 7.70(2H,d), 7.51(1H,dd),6.96(      2H,m), 6.76(1H,dd), 6.04(1H,d),5.76(1H,t), 4.61(2H,m), 2.25(2H,m),1.49(2H      ,m), 1.34(4H,m), 0.89(3H,t) 3600-2300, 1650,1610, 1520, 1445,1260, 1100,      980,850, 780 462(M.sup.+)419, 244 pale browncrystal       2(45)      ##STR321##       0.18(chloroform:methanol =4:1) 7.87(1H,dd), 7.82(2H,d), 7.30-7.10(5H,m),       6.92(2H,d), 6.84(1H,t),6.69(1H,dd), 5.57(1H,dd), 4.62(1H,dd),4.45(1H,dd)       3600-2300, 1650,1610, 1535, 1510,1460, 1260 471(M.sup.+)383, 253121      whitepowder       2(46)      ##STR322##       0.20(methylenechloride:methanol =5:1) 7.89(1H,dd), 7.83(2H,d), 6.96(2H,b      rd), 6.86(1H,t), 6.70(1H,dd),5.96-5.54(3H,m), 4.65(1H,dd),4.52(2H,d),      4.46(1H,dd) 3700-2200, 2940,1640, 1600, 1540,1510, 1460, 1340,1260,      1180, 1100,1000, 980, 850, 780 449(M.sup.+)339, 231219, 121 whitepowder

EXAMPLE 2(101)-2(107)

By the same procedures as reference example 1, 2 and example 2, using a corresponding carboxylic acid and 3-aminopyrocatechol which have corresponding substituents R² and R³, following compounds having the following physical data, shown in table [XIII] are given. ##STR323##

    TABLE XIII        Substituent R,R.sup.2,R.sup.3 Rf value in TLC     Example in the      general (developing No. formula (Ip) solvent) NMR (δppm) IR      (νcm.sup.-1) Mass Appearance               2(101)       0.38(methylenechloride:methanol=       3:1) (CDCl.sub.3)7.92(1H,d), 7.52(2H,d), 7.22(2H,d),7.00(1H,d),      6.96-6.74(3H,m), 5.77(1H,m), 5.04(1H,d), 4.50(1H,dd),3.59(3H,s),      0.88(3H,t) (liquid film)3500-2300, 1650,1590, 1480, 1275,1100 433(m.sup.+      )233,201 palebrownsolid       2(102)      ##STR324##       0.29(chloroform:methanol=       3:1) 8.03(1H,d), 7.71(1H,d), 7.48(2H,d),7.18(2H,d), 6.81(1H,d),      6.71(1H,d),4.79(1H,dd), 4.74(1H,dd), 4.35 (1H,dd) (liquid film)3600-3100,       1690,1610, 1540, 1460,1440, 1220 455, 453255, 253201 palebrownoil      2(103)       ##STR325##       0.30(chloroform:methanol=       3:1) 7.83(2H,d), 7.68(1H,d), 7.48(2H,d,7.17(2H,d), 6.86(1H,d), 6.51(1H,d      ),5.51(1H,dd), 4.70(1H,dd), 4.28(1H,dd) 3600-2500, 1680,1620, 1610,      15401450 201, 189175 whitesolid       2(104)      ##STR326##       0.25(chloroform:methanol=       3:1) 7.81(2H,d), 7.65(1H,d), 7.38(1H,d),6.77(1H,d), 5.75(1H,dd),      4.74-4.50(2H,m), 0.88(3H,t) 3300, 3200-2300,1640, 1620, 1545,1470, 1430,      1100,860, 740 427(M.sup.+)243, 175 browncrystal       2(105)      ##STR327##       0.44(methylenechloride:methanol= 17:3) (CD.sub.3 OD)7.20(3H,m),      6.74(4H,m), 5.22(1H,m),4.40(2H,m), 3.92(2H,m), 3.36(3H,s),1.73(2H,m),      1.31 (10H,m), 0.90(3H,t) 3600-2300, 1605, 1590,1470, 1420, 1380,      1300,1260, 1180, 1090, 1060,1040, 1015, 895, 840,760 465(M.sup.+)301,233 w      hitepowder       2(106)      ##STR328##       0.41(methylenechloride:methanol= 17:3) (CD.sub.3 OD)7.20(3H,m),      6,73(4H,m), 5.70(2H,m),5.20(1H,m), 4.41(3H,m), 3.36(3H,s),2.65(2H,m),      1.30(6H,m), 0.88(3H,t) 3600-2300, 1610, 1595,1470, 1420, 1380, 1300,1250,       990, 960, 895,840, 760 463(M.sup.+)343,233231 whitepowder  2(107)       ##STR329##       0.32(chloroform:methanol=       4:1) 7.99(2H,d), 7.63(1H,d), 7.00(2H,d),6.88(1H,d), 5.97(1H,m),      4.60(2H,m),4.05(2H,t), 3.88(3H,s), 1.83(2H,m),1.32(10H,m), 0.90(3H,t)      3600-2300, 1690, 1655,1610, 1500, 1470, 1280,1260, 1080, 910, 840,      233780, 760 509(M.sup.+)499, 329233 whitepowder

EXAMPLE 2(201)-2(204)

By the same procedure as reference example 1, 2 and example 2, using with a corresponding carboxylic acid and 3-aminopyrocatechol which have corresponding substituent R³, following compounds having following physical data were given. ##STR330##

TLC: Rf 0.21 (chloroform:methanol=3:1).

NMR: δ 8.03(1H, d), 7.70(1H, d), 7.48(2H, d), 7.20(2H, d), 6.71(1H, d), 6.65(1H, d), 5.57(1H, s), 4.70-4.40(2H, m), 2.62(2H, t).

IR: ν 3700-3000, 1680, 1625, 1610, 1535, 1470, 1440 cm⁻¹.

Mass: m/e 201, 179, 162.

Appearance: white powder. ##STR331## (The substituting position of tetrazolyl was not known.)

TLC: Rf 0.22 (methylene chloride:methanol=5:1);

NMR: δ 8.21(1H, d), 7.74(1H, d), 7.57(1H, d), 7.49(2H, d), 7.20(2H, d), 6.62(1H, d), 5.74(1H, dd), 4.89(1H, dd), 4.54(1H, dd).

IR: ν 3370, 3200-2300, 1695, 1630, 1610, 1520, 1430, 1270, 1140 cm⁻¹.

Mass: m/e 477(M⁺), 291, 201.

Appearance: white crystal. ##STR332##

less polar compound:

TLC: Rf 0.18 (methylene chloride:methanol=5:1).

NMR (CDCl₃): δ 9.88(1H, s), 7.81(1H, d), 7.45(3H, s), 7.18(2H, s), 6.69(1H, s), 6.64(1H, d), 6.04(1H, s), 5.60(1H, s), 4.50(1H, s), 3.84(3H, s), 0.88(3H, t).

IR: ν 3600-2300, 1695, 1630, 1610, 1515, 1470, 1280 cm⁻¹.

Mass: m/e 477(M⁺), 446, 291, 201.

Appearance: white crystal.

more polar compound:

TLC: Rf 0.12 (methylene chloride:methanol=5:1).

NMR (CDCl₃): δ 9.44(1H, s), 7.46(1H, s), 7.25(1H, s), 7.13(2H, s), 6.88(2H, s), 6.60-6.30 (2H, s), 5.20(1H, s), 4.20-3.60(2H, s), 3.72(3H, s), 0.83(3H, t).

IR: ν 3600-3000, 1695, 1630-1610, 1520, 1480, 1280 cm⁻¹.

Mass: m/e 477(M⁺), 446, 291, 201.

Appearance: white crystal.

EXAMPLE 2(301)

By the same procedure as example 2, using with 8-(p-pentylcinnamoyl)amino-1,4-benzodioxane-2-acetonitrile (synthesized in reference example 5), following compound having the following physical data was given. ##STR333##

TLC: Rf 0.36 (methylene chloride:methanol=5:1).

NMR: δ 7.88(1H, d), 7.70(1H, d), 7.47(2H, d), 7.20(2H, d), 6.84(1H, t), 6.63(1H, dd), 6.57(1H, d), 3.36(2H, d).

IR: ν 3300, 3200-2300, 1660, 1605, 1530, 1460 cm⁻¹.

Mass: m/e 433(M⁺), 233, 201.

Appearance: dark brown powder.

EXAMPLE 2(302)-2(303)

By the same procedure as example 2, using with a corresponding nitrile, following compounds having the following physical data were given. ##STR334##

TLC: 0.3 (methylene chloride:methanol=5:1).

IR: ν 1655, 1615, 1600, 1540, 1490 cm⁻¹.

Mass: m/e 391(M⁺), 349, 309, 217, 201, 191.

Appearance: pale yellow powder. ##STR335##

TLC: 0.22 (chloroform:methanol=9:1).

IR: ν 3300-2300, 2920, 1655, 1620, 1540, 1470, 1350, 1045, 980 cm⁻¹.

Mass: m/e 407(M⁺), 324, 292, 201.

Appearance: pale yellow crystal.

EXAMPLE 3 Synthesis of 8-(p-pentylcinnamoyl)amino-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester ##STR336##

Oxalyl chloride (3.4 ml) was added to p-pentylcinnamic acid (327 mg), and the mixture was stirred for 30 min at room temperature. Excess oxyalyl chloride was removed from the mixture under reduced pressure. The residue was dissolved to methylene chloride (5 ml). In an atmosphere of argon, a solution of 8-amino-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester (420 mg) in a mixture of methylene chloride (5 ml) and triethylamine (0.6 ml) was added slowly. The reaction solution was stirred for 1 hr at room temperature, and then poured into 0.1N hydrochloric acid. The mixture was extracted with ethyl acetate. The extract was washed with water, a saturated aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride, successively, dried, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:3) to give the title compound (140 mg) having the following physical data:

TLC: Rf 0.60 (ethyl acetate:hexane=1:1).

NMR (CDCl₃): δ 8.76(1H, dd), 8.23(1H, s), 7.72(1H, dd), 7.65(1H, d), 7.38(2H, d), 7.27(1H, t), 7.07(2H, d), 7.00(1H, s), 6.52(1H, d);

IR: ν 3270, 2930, 1730, 1660, 1630, 1530, 1430, 1290, 1260, 1180, 770 cm⁻¹.

Mass: m/e 4.33(M⁺), 404, 388, 376, 360, 318, 233, 201, 131.

Appearance: white powder.

EXAMPLE 4 Synthesis of 8-(p-pentylcinnamoyl)amino-4-oxo-4H-1-benzopyran-2-carboxylic acid ##STR337##

8-(p-pentylcinnamoyl)amino-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester (132 mg; synthesized in example 3) was dissolved into ethanol (10 ml). To the solution, an aqueous solution (1 ml) of sodium bicarbonate (126 mg) was added. The mixture was refluxed for 15 min. To the reaction solution mixture cooled to room temperature, water (20 ml) and 1N hydrochloric acid (2 ml) were added. The mixture was extracted with ethyl acetate. The extract was washed with water and a saturated aqueous solution of sodium chloride, dried, and concentrated under reduced pressure. The residue was washed with a mixture of ethyl acetate and hexane (1:1), and dried to give the title compound (62 mg) having the following physical data:

TLC: Rf 0.25 (ethyl acetate:methanol=5:1).

NMR: δ 8.66(1H, dd), 7.86(1H, dd), 7.73(1H, d), 7.53(2H, d), 7.43(1H, t), 7.22(2H, d), 7.15(1H, s), 7.08(1H, d).

IR: ν 3400, 2930, 1635, 1520, 1430, 1360 cm⁻¹.

Mass: m/e 405(M⁺), 361, 201, 181, 169, 131, 69.

Appearance: yellow powder.

EXAMPLE 4(1)-4(3)

By the same procedure as example 3 and 4, using with a corresponding carboxylic acid and 8-amino-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester which have corresponding substituent R³, following compounds having the following physical data, shown in table [XIV] were given. ##STR338##

                                      TABLE XIV                                    __________________________________________________________________________     Ex-                  Rf value                                                  am-                                                                               Substituent R,R.sup.3                                                                            in TLC                                Ap-                 ple                                                                               in the general    (developing                           pear-               No.                                                                               formula (Iq)      solvent)                                                                              NMR (δ ppm)                                                                               IR (ν cm.sup.-1)                                                                     Mass ance                __________________________________________________________________________     4(1)                                                                                                0.2 (methylene chloride: methanol = 5:1)                                              8.90(1H,dd), 7.88(1H,dd), 7.74(1H, d),                                         7.5-7.6(2H,m), 7.46(1H,t), 7.18 (1H,s),                                        6.95-7.05(2H,m), 6.88(1H, d),                                                                   1650, 1630, 1600, 1580,                                                        1540, 1510                                                                              459(M.sup.+) 415,                                                              351 255, 164                                                                        pale yellow                                                                    pow- der            4(2)                                                                               ##STR339##       0.20 (ethyl acetate: methanol = 5:1)                                                  8.75(1H,d), 7.76(1H,d), 7.68(1H,m),                                            7.54(2H,d), 7.22(2H,d), 7.16(1H,s), 6.99(1H,d)                                 , 2.64(2H,t), 2.50(3H,s), 1.64(2H,m),                                          1.20-1.50(4H,m) 0.90 (3H,t)                                                                     3450, 2930, 2850, 1735,                                                        1625, 1600, 1535, 1445,                                                        1270, 1210, 1180, 980,                                                                  419(M.sup.+) 219,                                                              201 131                                                                             pale yellow                                                                    pow- der            4(3)                                                                               ##STR340##       0.17 (chloroform: methanol = 4:1)                                                     8.46(1H,dd), 7.92(1H,dd), 7.92(2H, d),                                         7.46(1H,t), 7.32(2H,d), 7.08 (1H,s),                                           2.70(2H,t), 0.90(3H,t)                                                                          3270, 1700, 1650, 1630,                                                        1620, 1580, 1525, 1440,                                                                 175,                                                                                yellow pow-         __________________________________________________________________________                                                                der            

EXAMPLE 4(101)-4(104)

By the same procedure as example 3 and 4, using with corresponding carboxylic acid and 8-amino-1,4-benzodioxane-2-carboxylic acid ethyl ester, following compounds having the following physical data, shown in table [XV] were given. ##STR341##

                                      TABLE XV                                     __________________________________________________________________________                         Rf value                                                   Ex- Substituent R   in TLC                                 Ap-                 ample                                                                              in the general  (developing                            pear-               No. formula (Ir)    solvent)                                                                              NMR (δ ppm) IR (ν cm.sup.-1)                                                                     Mass ance                __________________________________________________________________________     4(101)                                                                                             0.10 (ethyl acetate: methanol = 10:1)                                                 (CD.sub.3 OD) 7.80(1H,d), 7.62(1H,d), 7.50(2H,d                                ), 7.20(2H,d), 6.92(1H,d), 6.78(1H,t),                                         6.62(1H,dd), 4.70(1H,dd), 4.54(1H,dd),                                         4.18(1H,dd), 2.62(2H,t), 1.62(2H,m),                                           1.20-1.45(4H,m), 0.90(3H,t)                                                                      3300, 2930, 2850, 1610,                                                        1530, 1440, 1260, 1180,                                                        1100, 975, 825,                                                                         395(M.sup.+) 351,                                                              201 195, 161 127,                                                              85   white pow-                                                                     der                 4(102)                                                                              ##STR342##     0.37 (chloroform: methanol = 4:1)                                                     7.92(2H,d), 7.69(1H,dd), 6.95(2H,dd), 6.84(1H,t                                ), 6.66(1H,dd), 4.66(1H,m), 4.45(1H,dd),                                       4.27(1H,dd), 4.02(2H,t), 1.81(2H,m),                                           1.31(8H,m), 0.88(3H,t)                                                                           3650-2400, 1605, 1440, 1250,                                                   1170, 1080, 895, 840,                                                                   409(M.sup.+)                                                                        pale yellow                                                                    crystal             4(103)                                                                              ##STR343##     0.39 (chloroform: methanol = 4:1)                                                     7.91(2H,d), 7.71(1H,dd), 6.96(2H,d), 6.93(1H,t)                                , 6.65(1H,dd), 5.78(2H,m), 4.68(1H,m),                                         4.53(2H,d), 4.41(1H,m), 4.31(1H,m),                                            2.09(2H,m), 1.32(6H,m), 0.88(3H,t)                                                               3650-2500, 1600, 1450, 1255,                                                   1180, 1090, 1000, 840,                                                                  407, 231                                                                            white pow-                                                                     der                 4(104)                                                                              ##STR344##     0.50 (chloroform: methanol = 4:1)                                                     7.92(2H,d), 7.72(1H,dd), 7.02(2H,d), 6.84(1H,t)                                , 6.65(1H,dd), 4.72(3H,t), 4.38(2H,m),                                         2.21(2H,m), 1.49(2H,m), 1.32(4H,m),                                                              3650-2500, 1605, 1440, 1255,                                                   1170, 1080, 990, 890, 830,                                                     760      405 219                                                                             yellow brown                                                                   pow- der            __________________________________________________________________________

EXAMPLE 4(201)-4(208)

By the same procedure as example 4, using with a corresponding carboxylic acid and a corresponding amine, following compounds having the following physical data, shown in table [XVI] were given.

    TABLE XVI         Rf value in TLC     Example  (developing No. Formula solvent) NMR      (δppm) IR (νcm.sup.-1) Mass Appearance               4(201)       ##STR345##       0.05(chloroform:methanol =4:1) (CDCl.sub.3 + DMSOd.sub.6)10.75(1H, s),      8.62(1H, d), 7.90-8.10(3H, m), 7.40-7.65(2H, m), 7.10-7.35(5H, m),      7.00(2H, d), 4.07(2H, t),2.70(2H, t), 1.85(4H, m) 3250, 2930, 1630,      1      1600,490, 1250, 1175, 840,755, 695 456(m.sup.+),412, 394,262, 253,121,      91 whitepowder       4(202)      ##STR346##       0.05(chloroform:methanol =4:1) (CDCl.sub.3 + DMSOd.sub.6)10.72(1H, s),      8.60(1H, d), 7.90-8.10(3H, m), 7.40-7.65(2H, m), 7.13(1H, dd),7.00(2H,      d), 6.91(1H, dd), 6.81(1H, d),4.07(2H, m), 2.92(2H, m), 1.90(4H, m)      3250, 2930, 1630, 1600,1500, 1250, 1250, 1175,840, 760, 695 462(m.sup.+),4      18, 400,276, 259,139, 121,97 yellowbrownpowder       4(203)      ##STR347##       0.05(chloroform:methanol =4:1) 8.80(1H, dd), 7.98(2H, d), 7.92(1H,      dd),7.58(1H, s), 7.50(1H, d), 7.00(2H, d),5.60-6.00(3H, m), 4.85-5.10(2H,       m),4.55(2H, d), 2.10(4H, m), 1.50(2H, m) 3350, 3060, 2930, 1640,1605,      1500-1530, 1360,1255, 1175, 995, 965,905, 840, 760  paleyellowpowder      4(204)       ##STR348##       0.47(methylenechloride:methanol =5:1) 803(1H, dd), 7.93(2H, d),      7.36-7.14(5H, m), 7.04(1H, t), 6.96(2H, d),6.83(1H, dd), 5.45(1H, dd),      4.60(1H,dt), 4.15(1H, dt) 3400-2300, 1645, 1610,1510, 1480, 1450,      1260,1060 485(m.sup.+),442, 439,411, 377,359 whitepowder  4(205)       ##STR349##       0.33(cyclohexane:ethyl acetate = 1:2) (CDCl.sub.3)9.1(1H, s), 8.53(1H,      d), 7.54(1H, d), 7.54(1H, s), 7.38(1H, t), 7.34(2H, d), 7.22(2H, d),      7.06(1H, t), 2.83(2H, t), 2.64(2H, t),2.48(2H, t), 2.28(3H, d), 1.89(2H,      m),1.65(2H, m), 1.33(4H, m), 0.90(3H, t) 3450, 3340, 2920, 2850,1710,      1660, 1610, 1500,1470, 1430, 1190 425(m.sup.+),306, 215,145 whitepowder      4(206)       ##STR350##       0.30(cyclohexane:ethyl acetate =1:2) (CDCl.sub.3)8.54(1H, s), 8.50(1H,      d), 7.50(1H, d),7.42(2H, d), 7.35(1H, t), 7.20(2H, d),7.04(1H, t),      6.20(1H, d), 2.80(2H, t),2.60(5H, m), 2.48(2H, t), 1.88(2H, m),1.64(2H,      m), 1.35(4H, m), 0.90(3H, t) 3300, 2950, 2860, 1710,1640, 1480 425(m.sup.      +),306, 215,211 whitepowder       4(207)      ##STR351##       0.30(ethyl acetate:ethanol =1:1) (CDCl.sub.3)8.64(1H, s), 8.52(1H, d),      7.75(1H, d),7.40-7.60(3H, m), 7.36(1H, t), 7.10-7.30(2H, m), 7.06(1H,      dt), 6.56(1H, d), 2.82(2H, t), 2.63(2H, t), 2.48(2H, t), 1.80-2.00(2H,      m) 1700, 1655, 1615, 15701520 411(m.sup.+),292, 211,201whitepowder      4(208)       ##STR352##       0.05(chloroform:methanol =4:1) (CDCl.sub.3 + DMSOd.sub.6):10.70(1H, s),      8.50(1H, dd),8.00(3H, m), 7.50(2H, m),7.02(2H, d), 5.60- 6.00(3H,      m),4.85-5.10(2H, m), 4.58(2H, d),2.10(4H, m), 1.50(2H, m) 3280, 2950,      1640,1605, 1590, 1500,1260, 1180, 1100,760  paleyellowpowder

EXAMPLE 4(301)-4(320)

By the same procedure as example 4, using with a corresponding carboxylic acid and a corresponding amine, following compounds having the following physical data, shown in table [XVII] were given.

                                      TABLE XVII                                   __________________________________________________________________________                                             Rf value in TLC                                                                (developing                            Example No.                                                                           Formula                          solvent)  Mass  Appearance             __________________________________________________________________________     4(301)                                                                                 ##STR353##                      0.48 (ethyl acetate)                                                                     383(M.sup.+), 365, 292,                                                        01    pale yellow                                                                    crystal                4(302)                                                                                 ##STR354##                      0.4 (ethyl acetate: hexane =                                                             397(M.sup.+), 292, 201,                                                        97, 141                                                                              white powder           4(303)                                                                                 ##STR355##                      0.10 (methylene chloride)                                                                395(M.sup.+), 287, 258,                                                        29, 167                                                                              pale brown                                                                     powder                 4(304)                                                                                 ##STR356##                      0.2 (cyclohexane: ethyl acetate =                                              :2)       383(M.sup.+), 264, 211,                                                        73    white powder           4(305)                                                                                 ##STR357##                      0.3 (cyclohexane: ethyl acetate =                                              :2)       423(M.sup.+), 304, 213,                                                        11, 187, 131                                                                         white powder           4(306)                                                                                 ##STR358##                      0.24 (cyclohexane: ethyl acetate                                               = 1:2)    431(M.sup.+), 312, 221,                                                        11, 125, 91                                                                          white powder           4(307)                                                                                 ##STR359##                      0.26 (cyclohexane: ethyl acetate                                               = 1:2)    465(M.sup.+), 346, 255,                                                        45, 211, 147                                                                         pale yellow                                                                    powder                 4(308)                                                                                 ##STR360##                      0.43 (ethyl acetate)                                                                     429(M.sup.+), 231, 229,                                                        01    white crystal          4(309)                                                                                 ##STR361##                      0.34 (ethyl acetate)                                                                     515(M.sup.+), 412,                                                                   white crystal          4(310)                                                                                 ##STR362##                      0.39 (ethyl acetate: hexane =                                                  1:1)      439(M.sup.+), 245                                                                    white crystal          4(311)                                                                                 ##STR363##                      0.34 (ethyl acetate)                                                                     459(M.sup.+), 461, 424,                                                        49, 265                                                                              white crystal          4(312)                                                                                 ##STR364##                      0.44 (ethyl acetate)                                                                     465(M.sup.+), 391                                                                    white crystal          4(313)                                                                                 ##STR365##                      0.34 (ethyl acetate)                                                                     419(M.sup.+), 225                                                                    pale brown                                                                     crystal                4(314)                                                                                 ##STR366##                      0.23 (ethyl acetate: hexane =                                                  1:1)      515(M.sup.+), 355, 321,                                                        61    white powder           4(315)                                                                                 ##STR367##                      0.38 (ethyl acetate: hexane =                                                  1:1)      415(M.sup.+), 221                                                                    white crystal          4(316)                                                                                 ##STR368##                      0.06 (ethyl acetate: hexane =                                                  1:3)      549(M.sup.+), 515, 463,                                                        55, 195, 161                                                                         white crystal          4(317)                                                                                 ##STR369##                      0.22 (ethyl acetate: hexane =                                                  1:1)      499(M.sup.+), 394,                                                                   white crystal          4(318)                                                                                 ##STR370##                      0.22 (ethyl acetate: hexane =                                                  1:1)      435(M.sup.+), 241                                                                    pale yellow                                                                    powder                 4(319)                                                                                 ##STR371##                      0.18 (ethyl acetate: hexane =                                                  1:1)      503(M.sup.+), 417, 400,                                                        99, 398, 309                                                                         white powder           4(320)                                                                                 ##STR372##                      0.21 (ethyl acetate: hexane =                                                  1:1)      515(M.sup.+), 429, 355,                                                        21    white                  __________________________________________________________________________                                                             crystal           

EXAMPLE 5 Synthesis of 8-[p-(4-phenylbutoxy)benzoylamino]-2-(5-tetrazolyl)-2,3-dihydrobenzoxazine ##STR373##

In an atmosphere of argon, a mixture of 8-[p-(4-phenylbutoxy)benzoylamino]-N-trifluoroacetyl-2,3-dihydrobenzoxazin-2-nitrile (316 mg), sodium azide (196 mg), ammonium chloride (161 mg) and dimethylformamide (2.5 ml) was stirred for 1 hr at 100° C. After reaction, the reaction solution was poured into a mixture of ice and dil. hydrochloric acid, the mixture was extracted with ethyl acetate. The extract was washed, dried over magnesium sulphate, and condensed under reduced pressure. The residue was dissolved into ethanol which was saturated with ammonia (50 ml). The solution was stirred for 20 hrs at room temperature and then concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (chloroform:methanol=3:1) to give the title compound (207 mg) having the following physical data:

TLC: Rf 0.36 (chloroform:methanol=3:1).

IR: ν 3600-2300, 1630, 1600, 1500, 1465, 1250, 1170 cm⁻¹.

Mass: m/e 470(M⁺), 376, 358, 253.

Appearance: brown powder.

EXAMPLE 5(1)-5(10)

By the same procedure as example 5, using with a corresponding nitrile, following compounds having the following physical data, shown in table [XVIII] were given.

    TABLE XVIII         Rf value       in TLC Example  (developing No. Formula solvent) NMR      (δppm) IR (νcm.sup.-1) Mass Appearance               5(1)       ##STR374##       0.30(methylenechloride:methanol =5:1) 8.09(1H, dd), 7.88(2H, d),      7.40-7.00(8H, m), 6.95(2H, d), 5.54(2H, s),4.03(2H, t), 2.71(2H, t),      1.95-1.75(4H, m) 3350, 3100-2300, 1610,1600, 1560, 1530, 1510,1450, 1260 4      43(m.sup.+),361, 343,253 white powder       5(2)      ##STR375##       0.30(methylenechloride:methanol =5:1) (CDCl.sub.3)8.10(1H, s), 7.68(2H,      d), 7.76-7.64(1H,d), 7.05(1H, t), 6.92(1H, t), 6.82(2H,d), 6.72(1H, d),      6.00-5.58(2H, m),5.46(2H, d), 4.47(2H, d) 3200, 3100-2300, 1600,1590,      1560, 1525, 1500,1250, 421(m.sup.+),331, 311,301, 231 white powder  5(3)       ##STR376##       0.36(methylenechloride:methanol =3:1) 7.88(2H, d), 7.22(6H, m),      6.93(2H, d),6.79(1H, t), 6.47(1H, dd), 5.68(1H, t),4.02(2H, t), 3.89(1H,      dd), 3.73(1H, dd),2.67(2H, m), 1.84(4H, m) 3600-2300, 1630, 1600,1500,      1465, 1250, 1170 470(m.sup.+),376, 358,253, brown powder       5(4)      ##STR377##       0.20(chloroform:methanol =4:1) (CDCl.sub.3 + CD.sub.3 OD +       DMSOd.sub.6)8.06(2H, d), 7.85(1H, d), 7.74(1H, d),7.64(1H, d), 7.46(1H,      m), 7.38(1H, d),7.27(1H, dd), 7.03(2H, d), 5.80(1H, m),5.53(2H, s),      5.00(2H, m), 4.06(2H, t),2.08(2H, m), 1.83(2H, m), 1.45(6H, m) 3220,      2930, 2850, 1620,1600, 1495, 1250, 1225,1170, 1055, 840, 825 471(m.sup.+)      ,389, 231,121 grey powder       5(5)      ##STR378##       0.20(chloroform:methanol =4:1) (DMSOd.sub.6)8.06(2H, d), 7.95(1H, d),      7.80(1H, d),7.61(1H, d), 7.20-7.55(8H, m), 7.10(2H, d), 5.58(2H, s),      4.31(2H, t), 3.30(1H, s), 3.10(2H, t) 3270, 1620, 1600, 1490,1260, 1175,      835 465(m.sup.+),422, 383,262, 225121, 105 grey powder       5(6)      ##STR379##       0.20(chloroform:methanol =4:1) (DMSOd.sub.6)8.04(2H, d), 7.94(1H, d),      7.78(1H, d),7.60(1H, d), 7.49(1H, d), 7.41(1H, t),7.35-7.11(6H, m),      7.06(2H, d), 5.58(2H, s), 4.09(2H, t) 3500-2300, 1620, 1600,1570, 1520,      1490, 1250 493(m.sup.+),411, 253 grey powder       5(7)      ##STR380##       0.34(chloroform:methanol =4:1) 7.77(1H, d), 7.56-6.89(7H, m),6.47(2H,      d), 6.20(1H, dd), 3.87(1H,dd), 2.62(2H, t), 0.90(3H, t) 3300, 2950,      1670, 1630,1540, 1450, 1190 403(m.sup.+),346, 328,201 pale brownpowder      5(8)       ##STR381##       0.10(chloroform: methanol =4:1)   428(M.sup.+),410, 400,296, 201 yellow      powder       5(9)      ##STR382##       0.24(chloroform:methanol =3:1)   418(M.sup.+),201 white powder   5(10)       ##STR383##       0.7(methylenechloride:methanol =3:1)   296, 253 yellow powder

EXAMPLE 6 Synthesis of 4-[2-(p-pentyl-2-methylcinnamoyl)-aminophenoxy]butanoic acid and ethyl ester thereof ##STR384##

A mixture of 2-(p-pentyl-2-methylcinnamoyl)-aminophenol (267 mg), 4-bromobutanoic acid ethyl ester (322 mg), potassium carbonate (135 mg) and acetone (2 ml) was refluxed overnight. After cooling, the reaction solution was diluted with ethyl acetate, precipitation was removed by filtration from the solution. The solution was concentrated under reduced pressure to give the title compound (ester) having the following physical data:

TLC: Rf 0.66 (toluene:ethyl acetate=10:1).

Mass: m/e 437(M⁺).

Ester obtained was dissolved into methanol (3.2 ml). To the solution, a 2N aqueous solution of sodium hydroxide (1.64 ml), and the solution was stirred for 1.5 hrs at 40° C. After reaction, the solution was acidified with dil. hydrochloric acid. The mixture was extracted with ethyl acetate. The extract was washed with water, dried and concentrated under reduced pressure to give the title compound (acid; 285 mg) having the following physical data:

TLC: Rf 0.60 (methylene chloride:methanol=5:1).

IR: ν 3470, 3200-2300, 1710, 1670, 1620, 1600, 1530, 1450, 750 cm⁻¹.

NMR (CDCl₃): δ 8.44(1H, dd), 8.28(1H, s), 7.45(1H, s), 7.30(2H, d), 7.18(1H, dd), 4.11(2H, t).

Mass: m/e 409(M⁺), 215, 187.

Appearance: white powder.

EXAMPLE 6(1)-6(2)

By the same procedure as Example 6, using a corresponding phenol, following compounds were given. ##STR385##

TLC: Rf 0.48 (ethyl acetate).

IR: ν 3320, 3200-2300, 1700, 1660, 1630, 1610, 1540 cm⁻¹.

NMR (CDCl₃): δ 8.40(1H, d), 8.22(1H, s), 7.60(1H, d), 7.34(2H, s), 7.04(2H, d), 6.85(1H, dd), 6.76(1H, d), 6.69(1H, dd).

Mass: m/e 395(M⁺), 201, 195.

Appearance: white powder. ##STR386##

TLC: 0.4 (methylene chloride:methanol=5:1).

IR: ν 1655, 1600, 1520, 1445 cm⁻¹.

Mass: m/e 445(M⁺), 363, 345, 255, 191, 147.

Appearance: pale yellow powder.

EXAMPLE 7 Synthesis of 8-[3-(p-pentylphenyl)propionyl]amino-2-(5-tetrazolyl)-1,4-benzodioxane ##STR387##

8-(p-pentylcinnamoyl)amino-2-(5-tetrazolyl)-1,4-benzodioxane (216 mg; synthesized in example 2(1)) and palladium-carbon (50 mg; content 5%) were suspended in a mixed solvent (6 ml) of methanol, ethanol and ethyl acetate (1:1:1). In an atmosphere of hydrogen, the suspension was stirred for 90 min at room temperature. After stirring, the suspension was filtered through celite. The filtrate was condenced under reduced pressure. The residue was purified by column chromatography on silica gel (methylene chloride:methanol=19:1) to give the title compound (202 mg) having the following physical data:

TLC: Rf 0.54 (methylene chloride:methanol=4:1).

NMR (CDCl₃): δ 7.28(1H, s), 7.11(4H, 2d), 6.76(2H, m), 6.60(1H, dd), 5.68(1H, t), 4.93(1H, dd), 3.04(2H, t), 2.77(2H, m), 2.56(2H, t), 1.58(2H, m), 1.30(4H, m), 0.88(3H, t).

IR: ν 3600-2300, 1650, 1615, 1530, 1460, 1260, 1100, 780 cm⁻¹.

Mass: m/e 421(M⁺), 219.

Appearance: white crystal.

EXAMPLE 8 Synthesis of 8-[p-(6-hydroxyhexyloxy)benzoyl]amino-2-(5-tetrazolyl)-1,4-benzodioxane ##STR388##

A 1N aqueous solution of sodium hydroxide (0.5 ml) was added to a solution of 8-[p-(6-acetyloxyhexyloxy)benzoyl]-amino-2-(5-tetrazolyl)-1,4-benzodioxane (100 mg; synthesized in example 1 (96)) in methanol (0.5 ml) at room temperature. The reaction solution was stirred for 10 min at the same temperature, and then concentration under reduced pressure. To the residue, dil. hydrochloric acid was added and the mixture was extracted with ethyl acetate. The extract was dried and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (methylene chloride:methanol=100:1) to give the title compound (95 mg) having the following physical data:

TLC: Rf 0.23 (methylene chloride:methanol=5:1).

NMR: δ 7.89(2H, d), 7.46(1H, dd), 6.95(2H, d), 6.92(1H, t), 6.76(1H, dd), 4.02(2H, t), 3.60(2H, t).

IR: ν 3400, 3200-2300, 1630, 1600, 1520, 1500 1440, 1250, cm⁻¹ ;

Mass: m/e 439 (M⁺), 221, 149, 121.

Appearance: white amorphous.

EXAMPLE 9 Synthesis of 8-[p-[5-(N,N-dimethylamino)pentyloxy]cinnamoyl]amino-1,4-benzodioxane sodium salt ##STR389##

A 40% aqueous solution of dimethylamine (1 ml) was dropped to a solution of 8-[p-(5-bromopentyloxy)cinnamoyl]amino-1,4-benzodioxane (176 mg; synthesized in example 1 (113)). The solution was stirred for 1 hr at room temperature. Volatile matter was removed with vacuum pump for 1 hr at room temperature, and for 3 hrs at 90° C. The residue was dissolved into methanol (1 ml), to the solution, a 2N aqueous solution of sodium hydroxide (360 μl). The mixture was condensed under reduced pressure. To the residue, small amount of methanol and hexane (4ml) were added. The mixture was filtered, and volatile matter was removed from the filtrate with vacuum pump overnight at room temperature and overnight at 80° C. to give the title compound (179 mg) having the following physical data:

TLC: Rf 0.33 (ethyl acetate:acetic acid:water=3:1:1).

NMR: δ 7.87(2H, d), 7.62(1H, dd), 6.98(2H, d), 6.86(1H, t), 6.71(1H, dd), 4.06(2H, t), 2.85(2H, t), 2.64(2H, s).

IR: ν 3430, 2930, 1655, 1605, 1505, 1445, 1255 cm⁻¹.

Mass: m/e 452(M⁺), 233.

Appearance: white powder.

EXAMPLE 10 Synthesis of 8-(p-octyloxybenzoyl)amino-2-(5-tetrazolyl)-1,4-benzodioxane-7-carboxylic acid ##STR390##

8-(p-octyloxybenzoyl)amino-2-(5-tetrazolyl)-1,4-benzodioxane-7-carboxylic acid methyl ester (332 mg; synthesized in example 2 (107) was dissolved in methanol (1.5 ml). To the solution, a 1N aqueous solution of sodium hydroxide (1.36 ml), and the mixture was stirred for 50 min at room temperature and for 2 hrs at 40° C. After cooling, 1N hydrochloric acid (2 ml) was added to the solution. The mixture was extracted with ethyl acetate. The extract was dried and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (chloroform:methanol=9:1) to give the title compound (263 mg) having the following physical data:

TLC: Rf 0.15 (chloroform:methanol=4:1).

NMR: δ 8.00(2H, d), 7.68(1H, d), 6.98(2H, d), 6.82(1H, d), 6.04(1H, m), 4.56(2H, m), 4.03(2H, t), 1.82(2H, m), 1.31(10H, m), 0.88(3H, t).

IR: ν 3600/2300, 1680, 1640, 1600, 1490, 1460, 1250, 1170, 1080, 900, 840, 760, cm⁻¹.

Mass: m/e 495(M⁺), 477, 383, 233.

Appearance: pale brown powder.

EXAMPLE 11 Synthesis of 8-(p-pentylcinnamoyl)amino-2-(5-tetrazolyl)-6-methyl-1,4-benzodioxane sodium salt ##STR391##

8-(p-pentylcinnamoyl)-2-(5-tetrazolyl)-6-methyl-1,4-benzodioxane (50 mg; synthesized in example 2 (103)) was dissolved in methanol (0.5 ml). To the solution, equivalent molar of a 1N aqueous solution of sodium hydroxide was added. The solution was stirred and then evaporated to dryness to give the title compound (51 mg).

EXAMPLE 11(1)

By the same procedure as example 11, corresponding sodium salts of the compounds synthesized in examples (other than example 11 and esters) were given.

EXAMPLE 12

8-[p-(3E-hexenyloxy)benzoyl]amino-2-(5-tetrazolyl)-1,4-benzodioxane (0.5 g), cellulose calcium gluconate (200 mg; disintegrator), magnesium stearate (100 mg; lubricator) and microcrystalline cellulose (9.2 g) were admixed and punched out in conventional manner to give 100 tablets each containing 5 mg of the active ingredient. 

What is claimed is:
 1. A (fused) benz(thio) amide of the formula: ##STR392## wherein A represents a single bond or a methylene, ethylene, trimethylene, tetramethylene, vinylene, propenylene, butenylene, butadienylene or ethylene group optionally substituted by one, two or three straight or branched alkyl group(s) of from 1 to 10 carbon atom(s) and/or phenyl group(s);B represents a ring of formula: ##STR393## T represents an oxygen atom or a sulphur atom. R¹ represents a group of formula: ##STR394## wherein R⁵ and R⁶ independently represent a hydrogen atom, a halogen atom or a straight or branched alkyl, alkenyl or alkynyl group of up to 20 carbon atom(s), one, two, three, four or five of the optional carbon atom(s) being unreplaced or replaced by oxygen atom(s), sulphur atom(s), halogen atom(s), nitrogen atom(s), benzene ring(s), thiophene ring(s), naphthalene ring(s), carbocyclic ring(s) of from 4 to 7 carbon atom(s), carbonyl group(s), carbonyloxy group(s), hydroxy group(s), carboxy group(s), azido group(s) and/or nitro group(s); R² represents a hydrogen atom or a straight or branched alkyl group of from 1 to 6 carbon atom(s); R³ represents a hydrogen atom, a halogen atom, a hydroxy group, a nitro group, a group of general formula:

    --COOR.sup.7,

wherein R⁷ represents a hydrogen atom or a straight or branched alkyl group of from 1 to 6 carbon atom(s) or a straight or branched alkyl, alkoxy or alklthio group of from 1 to 6 carbon atom(s); R⁴ represents a group of formula: ##STR395## wherein U represents an oxygen atom or a sulphur atom;R⁸ represents a hydrogen atom or a straight or branched alkyl group of from 1 to 6 carbon atom(s); n and m each represent an integer of from 1 to 10, respectively, and p and q each represent zero or an integer of from 1 to 10, respectively; or non-toxic salts thereof.
 2. A compound according to claim 1, wherein A is a single bond, and T is an oxygen atom.
 3. A compound according to claim 2, wherein R¹ is a group of the formula: ##STR396## wherein R⁵ and R⁶ have the same meaning as set forth in claim
 1. 4. A compound according to claim 3, wherein R⁵ is a hydrogen atom, and R⁶ is a hydrogen atom or a straight or branched alkyl group of from 1 to 20 carbon atom(s).
 5. A compound according to claim 4, wherein the compound is selected from the group consisting of8-(p-pentylbenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-pentylbenzoyl)amino-4-oxo-4H-1-benzopyran-2-carboxylic acid and ethyl ester thereof, 8-(p-hexylbenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-heptylbenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-octylbenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran and 8-(p-nonylbenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyranand sodium salts thereof.
 6. A compound according to claim 3, wherein R⁵ is a hydrogen atom, and R⁶ is a straight or branched alkoxy group of from 1 to 19 carbon atom(s).
 7. A compound according to claim 6 wherein the compound is selected from the group consisting of8-(p-butoxybenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-pentyloxybenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-hexyloxybenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-heptyloxybenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-nonyloxybenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-octyloxybenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-heptyloxybenzoyl)amino-2-(5-tetrazolyl)-6-fluoro-4-oxo-4H-1-benzopyran 8-(p-octyloxybenzoyl)amino-2-(5-tetrazolyl)-6-methyl-4-oxo-4H-1-benzopyran and 8-(p-heptyloxybenzoyl)amino-2-(5-tetrazolyl)-6-methyl-4-oxo-4H-1-benzopyranand sodium salts thereof.
 8. A compound according to claim 3, wherein R⁵ is a hydrogen atom, and R⁶ is a straight or branched alkenyloxy group of from 3 to 19 carbon atoms.
 9. A compound according to claim 8, wherein the compound is selected from the group consisting of8-[p-(2E,7-octadienyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-geranyloxybenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-(2E-nonenyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-(2E-octenyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-(7-octenyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-(2E-heptenyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-(2E-hexenyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-(2E,7-octadienyloxy)benzoyl]amino-2-(5-tetrazolyl)-6-fluoro-4-oxo-4H-1-benzopyran, 8-[p-(2E-octenyloxy)benzoyl]amino-2-(5-tetrazolyl)-6-methyl-4-oxo-4H-1-benzopyran, 8-[p-(7-octenyloxy)benzoyl]amino-2-(5-tetrazolyl)-6-methyl-4-oxo-4H-1-benzopyran, 8-[p-(2E,7-octadienyloxy)benzoyl]amino-2-(5-tetrazolyl)-6-methyl-4-oxo-4H-1-benzopyran and 8-[p-(2E,7-octadienyloxy)benzoyl]amino-2-(5-tetrazolyl)-6-chloro-4-oxo-4H-1-benzopyranand sodium salts thereof.
 10. A compound according to claim 3, wherein R⁵ is a hydrogen atom, and R⁶ is a straight or branched alkynyloxy group of from 3 to 19 carbon atoms.
 11. A compound according to claim 10, wherein the compound is 8-[p-(2-octynyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran or sodium salt thereof.
 12. A compound according to claim 3, wherein R⁵ is a hydrogen atom, and R⁶ is a straight or branched alkoxy group of from 1 to 18 carbon atom(s) which is substituted by one or more hlaogen atom(s).
 13. A compound according to claim 12, wherein the compound is selected from the group consisting of8-[p-(4-chlorobutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-(5-chloropentyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-(6-chlorohexyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 8-[p-(6-chlorohexyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 8-[p(7-chloroheptyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 8-[p-(8-chlorooctyloxy)benzoyl]amino-2-(5-tetrazolyl)-6-methyl-4-oxo-4H-1-benzopyran, 8-[p-(7-chloroheptyloxy)benzoyl]amino-2-(5-tetrazolyl)-6-methyl-4-oxo-4H-1-benzopyran and 8-[p-(8-chlorooctyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyranand sodium salts thereof.
 14. A compound according to claim 3, wherein R⁵ is a hydrogen atom, and R⁶ is a phenyl group, a phenylalkyl group, wherein the alkyl moiety is an alkyl group of from 1 to 8 carbon atom, a phenylalkyloxy group, wherein the alkyl moiety is an alkyl group of from 1 to 8 carbom atom(s), a phenylalkenyloxy group, wherein the alkenyl moiety is an alkenyl group of from 2 to 8 carbon atom(s), a naphthyl group, a naphthylalkyl group, wherein the alkyl moiety is an alkyl group of from 1 to 8 carbon atom(s), a naphthylalhyloxy group, wherein the alkyl moiety is an alkyl group of from 1 to 8 carbon atom(s) or a naphthylalkenyloxy group, wherein the alkenyl moiety is an alkenyl group of from 2 to 8 carbon atom, each of which may be unsubstituted or substituted by one or more straight or branched alkyl group(s) of from 1 to 8 carbon atom(s), one or more hydroxy group(s), one or more halogen atom(s) and/or one or more nitro group(s).
 15. A compound according to claim 14, wherein the compound is selected from the group consisting of8-[p-(3-phenylpropoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-(3-phenyl-2E-propenyloxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-6-methyl-4-oxo-4H-1-benzopyran, 8-[p-[2-(2-naphthyl)ethoxy]benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-[2-(2-naphthyl)ethoxy]benzoyl]amino-2-(5-tetrazolyl)-6-methyl-4-oxo-4H-1-benzopyran 8-[p-[3-(3,4-dichlorophenyl)propoxy]benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-[3-(3,4-dichlorophenyl)propoxy]benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-[3-(p-chlorophenyl)butoxy]benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-[p-[3-(p-chlorophenyl)butoxy]benzoyl]amino-6-methyl-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran and 8-[p-[3-(p-chlorophenyl)propoxy]benzoyl]amino-6-methyl-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyranand sodium salts thereof.
 16. A compound according to claim 3, wherein R⁵ is a hydrogen atom, and R⁶ is a straight or branched alkoxy group of from 1 to 18 carbon atom(s) which may be substituted by one or more thiophene ring(s).
 17. A compound according to claim 16, wherein the compound is selected from the group consisting of8-[p-[4-(2-thienyl)butoxy]benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran and 8-[p-[4-(2-thienyl)butoxy]benzoyl]amino-2-(5-tetrazolyl)-6-methyl-4-oxo-4H-1-benzopyranand sodium salts thereof.
 18. A compound according to claim 1, wherein A is a vinylene group which may be unsubstituted or substituted by straight or branched alkyl group(s) of from 1 to 6 carbon atom(s) or phenyl group(s) and T is an oxygen atom.
 19. A compound according to claim 18, wherein R¹ is a group of the general formula: ##STR397## wherein R⁵ and R⁶ have the same meaning as set forth in claim
 1. 20. A compound according to claim 19, wherein R⁵ is a hydrogen atom, and R⁶ is a hydrogen atom or a straight or branched alkyl group of from 1 to 20 carbon atom(s).
 21. A compound according to claim 20, wherein the compound is selected from the group consisting of8-(p-pentylcinnamoyl)amino-4-oxo-4H-1-benzopyran-2-carboxylic acid and methyl ester thereof, 8-(p-pentylcinnamoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-pentylcinnamoyl)amino-2-(5-tetrazolyl)-6-methyl-4-oxo-4H-1-benzopyran, 8-(p-pentylcinnamoyl)amino-2-(5-tetrazolyl)-6-fluoro-4-oxo-4H-1-benzopyran, 8-(p-pentylcinnamoyl)amino-6-methyl-4-oxo-4H-1-benzopyran-2-carboxylic acid and ethyl ester thereof, 8-(p-butylcinnamoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-hexylcinnamoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-heptylcinnamoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran and 8-cinnamoylamino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyranand sodium salts thereof.
 22. A compound according to claim 19, wherein R⁵ is a hydrogen atom, and R⁶ is a straight or branched alkoxy group of from 1 to 19 carbon atom(s).
 23. A compound according to claim 22, wherein the compound is selected from the group consisting of8-(p-hexyloxycinnamoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran, 8-(p-heptyloxycinnamoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran and 8-(p-isohexyloxycinnamoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyranand sodium salts thereof.
 24. A compound according to claim 19, wherein R⁵ is a hydrogen atom, and R⁶ is a straight or branched alkynyloxy group of from 3 to 19 carbon atoms.
 25. A compound according to claim 24, wherein the compound is 8-[p-(2-octynyloxy)cinnamoyl]amino-4-oxo-4H-1-benzopyran-2-carboxylic acid or and ethyl thereof or a sodium salt thereof.
 26. A compound according to claim 19, wherein R⁵ is a hydrogen atom, and R⁶ is a straight or branched alkoxy group of from 1 to 18 carbon atom(s) which is substituted by one or more halogen atom(s).
 27. A compound according to claim 26, wherein the compound is selected from the group consisting of8-[p-(5-chloropentyloxy)cinnamoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran and 8-[p-(6-chlorohexyloxy)cinnamoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyranand sodium salts thereof.
 28. A pharmaceutical composition which contains as an active ingredient, at least one compound of the formula (I) as defined in claim 1, together with a pharmaceutically acceptable carrier and/or coating. 